@dankowalskichm@Chem_CP@EvaHeviaGroup@kjedler@DCBPunibern As for the effect of H2O, it reacts with organometallic reagents lowering the yield,Yet surprisingly this does not cause clogging in the presence of DES.Additionally the structure of the DES can be altered greatly by the presence of water which may have some effect.
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@dankowalskichm@Chem_CP@EvaHeviaGroup@kjedler@DCBPunibern Great question, The reason for low carrier ratio being higher yielding is mostly down to size of droplets.With low carrier phase larger droplets are observed which offers greater chance of organometallic reagent meeting the substrate leading to a successful reaction.
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Today I'm happy to present some recent work we've published on highly reactive hydrocarbon soluble alkylsodium reagents and their application in the benzylic aroylation of toluenes. https://t.co/uHUQza4dxY
@EvaHeviaGroup@DCBPunibern#RSCPoster#RSCOrg#RSCInorg#Organosodium