Andy Shih

Neuroscientist, sorting out the brain's plumbing in health and disease.

[Andy Shih @AndyShih_Lab]

@DAgalliu Thank you, Dritan!

[Vanessa Coelho-Santos @vcoelhosantos]

Happy to see this work finally published 🙌!! A team effort with @AndyShih_Lab!! We show that from birth to old age, #microglia 🧠 undergo striking shifts in morphology, complexity, and injury response. #liveimaging #neuroimmune #neonatalbrain #agingbrain

[Andy Shih @AndyShih_Lab]

@eyolab Thank you for sharing the work @eyolab!

[Andy Shih @AndyShih_Lab]

It is debated whether poor #blood flow underlies white matter loss in #aging. Our recent study in aged mice supports this idea: Impaired drainage through rare, deep-reaching #venules causes mild #hypoperfusion that triggers inflammation and demyelination.
https://t.co/nDVjgZjnWa

[Society for Neuroscience (SfN) @SfNtweets]

Groundbreaking scientific discoveries don’t happen in isolation.

Michelle Gray, PhD, SfN Program Committee member, shares how you can enhance your research through valuable exchange w/ the scientific community at #SfN25.

Submit your abstract today!

🔗 https://t.co/P5J61GEG56

[Andy Shih @AndyShih_Lab]

Very happy to share @stephkbeee's study in @PNASNews on the effects of capillary injury in the brain. Protect those heads!

Stephanie is starting her own lab at @CUAnschutz soon and excited to see her research grow!

[Stephanie Bonney @stephkbeee]

Ever wonder if small injuries to capillaries have lasting consequences? Our work exploring this question is now out! None of this would have been possible without the help of some brilliant minds - @NielsonCara @sosamariaj @OrlaBonBon @AndyShih_Lab https://t.co/3ncBYc1vhv

[Andy Shih @AndyShih_Lab]

Growth hormone acts on #pericytes, stimulating #angiogenesis and supporting #oligodendrocyte survival & growth after neonatal hypoxia.

An impressive study by the Mei Lab (https://t.co/Tzt4WV0BBv) in @NeuroCellPress. Preview written with @vcoelhosantos (https://t.co/fxXwWGbVDl)

[Andy Shih @AndyShih_Lab]

@stephkbeee @SiegenthalerLab @sosamariaj @NielsonCara @stephkbeee, it's so exciting to see your dream come true after all the long hours in the lab. You will be an amazing PI and I'm excited to see your research grow! Prospective trainees, keep your eyes on the future Bonney lab for cool imaging projects!

[Andy Shih @AndyShih_Lab]

@OrlaBonBon @stephkbeee Orla, it was so much fun that the time flew by too quickly. The van Veluw lab is very lucky to have such a great scientist and thoughtful team member!

[Andy Shih @AndyShih_Lab]

@MSEFulton Such a cool image, Mia! Looking forward to hearing more in the future!

[Andy Shih @AndyShih_Lab]

@nickchavkin @uwpediatrics Yeah @nickchavkin! Congrats and looking forward to welcoming you to the SCRI family soon!

[Andy Shih @AndyShih_Lab]

@Nrklug The pleasure was ours, Nick! Excited to see future work from your new lab. Your techniques are awesome. Come back and visit soon.

[Andy Shih @AndyShih_Lab]

@AllenInstitute Thank you for sharing @AllenInstitute !

[Andy Shih @AndyShih_Lab]

@neurodevKathy Thanks for the support Kathy!

[Andy Shih @AndyShih_Lab]

@Nrklug @franca_schmid @AllenInstitute @HannahCBennett7 @yongsookimlab @stephkbeee @sosamariaj @JennyYuandongLi Thanks Nick! Lets try some deep imaging when you visit the lab.

[Andy Shih @AndyShih_Lab]

What makes cerebral white matter more vulnerable with age? In this mouse study, we show that large and rare venules are bottlenecks for blood flow in the white matter. Deep branches of these venules are constricted with age, leading to reduced blood flow.
https://t.co/SYqntCvVBa

[Andy Shih @AndyShih_Lab]

@AmrnMughal Thank you Amreen! Also, I see you have started your new lab! You deserve the REAL congrats! Happy to talk imaging and veins/venules in the future.

[Andy Shih @AndyShih_Lab]

@Wilcock_v2 Thanks so much Donna!

[Andy Shih @AndyShih_Lab]

@alankrit97 Thanks Alankrit. It's possible that some out of focus damage occurred, but if the concern was inadvertent, direct damage to arterioles, it is less likely. The selected capillary targets were not underneath pial vessels, and distant from the transitional zone in the x-y dimension.

[Andy Shih @AndyShih_Lab]

It's all connected... In this study, we show that tiny injuries created deep in the brain's capillary bed can contribute broadly to blood flow impairment by constricting upstream supply vessels. https://t.co/D38oMFbIwD