Ann Bauer Sc.D.

“The arc of history bends towards showing that medications do affect the developing baby.” Dr. Adam Urato

[Ann Bauer Sc.D. @AnnBauerZ]

Statement on the prenatal #acetaminophen (#Tylenol, #paracetamol use & offspring neurodevelopment (#ADHD, #autism) research from my co-author, Dr. Andrea Baccarelli, Harvard Dean of Public Health:

[Autism Research Institute @ariConference]

A new statistical framework developed by researchers at the Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University School of Medicine, and Kaiser Permanente Northern California offers an improved understanding of how genetics and environment contribute to autism risk.

https://t.co/kvfqOuhjXz

[Autism Research Institute @ariConference]

A major study suggests that some of the groundwork for brain development may be shaped before birth through a surprising partnership between a baby’s genes and gut microbes. Researchers found that epigenetic changes present at birth can influence how the gut microbiome develops during the first year of life, and certain combinations were linked to early signs of autism and ADHD by age three.

https://t.co/KSQcPSxAQq

[Dr 🫥:. #Autism or #dyslexia. Anxiety kills @draevans]

An interesting trend - more recent diagnoses have less genetic basis.

Generally autism has a heritability of 90%. Any change is this number points to increased environmental factors (or inappropriate diagnosis maybe) https://t.co/fsR1xLWhJE

[דורון גולדברג Doron Goldberg MD @GoldbergDoron]

בטח כל העוקבים שלי כאן מודעים למאבק שלי בתכשירי האקמול.

אתמול עוד חדשות טובות.
מטופלת שלי מהעבר שפגשה אותי ברחוב. אחות במקצועה. עידכנה אותי שהרופאים במרפאה שלה מאוד התרשמו מהמאבק שלי וממליצים למטופלות להיזהר מתכשירי אקמול.

זאת אומרת שהמאבק תופס. https://t.co/2z78raRg0C

[Paul Whiteley @PaulWhiteleyPhD]

"Similarly, a more recent ASD diagnosis was associated with decreased genetic risk for ASD" https://t.co/J83lNcsItj Would this imply 'more environment' than genetics perhaps? Obviously taking into account broadening diagnostic criteria too.

[Ann Bauer Sc.D. @AnnBauerZ]

Two Distinct Autism Subtypes Identified Via Brain Connectivity - https://t.co/WigTuTIv1B via @neurosciencenew

[Ann Bauer Sc.D. @AnnBauerZ]

Why has the investigation of the neurodevelopmental effects of #acetaminophen (#Tylenol) been limited to exposure during pregnancy?

In new research of other neurotoxins, they found that the developing brain is especially vulnerable in infant early life.
https://t.co/DtApP8kHOh

[Ann Bauer Sc.D. @AnnBauerZ]

@IntegralAnswers Please be aware that the valproate and autism association has also been attenuated to the null (showing no relationship) in a sibling control analysis. Corrected link: https://t.co/uOv1PWmbfN

[Ann Bauer Sc.D. @AnnBauerZ]

There are 3 limitations of the sibling analyses of #acetaminophen which should preclude one from using them to make firm conclusions.

The most obvious issue is extreme exposure misclassification. These studies report 2-7% of women exposed when maternal reported studies in the same populations, during the time period, report over 55%. The studies with the best exposure assessments, using biomarkers to measure body burden of acetaminophen, consistently found strong effects (see graphic)

2) The current thinking on autism is genetic predisposition is required for a toxic exposure to lead to ASD. Therefore, genetics would be a mediator on the causal pathway. Sibling analyses treat genetics as a confounder which would bias results. https://t.co/uRhr8pL1jK

3) A substantial divergence in associations in the sibling bidirectional analyses indicates unaddressed sources of bias (in Ahlqvist too) https://t.co/JR4NKeHH1b

[Paul Whiteley @PaulWhiteleyPhD]

Beyond the Headlines: Examining the Evidence Around Acetaminophen and Autism Risk https://t.co/C0rHPxQGOr Including the limitations around 'observational studies' and perhaps what studies need to be done. Refreshingly scientific and evidence-based.

[BrooklynDad_Defiant!☮️ @mmpadellan]

Good morning and Happy Wednesday to everyone who agrees that the audio of Speaker Johnson ADMITTING that he's planning on cutting Medicare, Medicaid, and Social Security SHOULD BE A HUGE STORY.

Don't let him slide on this.

[sean @Blindspots1983]

@AnnBauerZ and the follow on study shows us the mechanism: TLR9 mediated innate immune signaling

https://t.co/jbjPFdBSUs

[Mike Levin @MikeLevin]

Scientists at Trump’s EPA say they are being told to make chemical risks “disappear on paper.” Not to study or manage them, but to make them vanish.

When a safety test on a household chemical shows danger, supervisors reportedly ask to keep shrinking the scenario until the poison looks safe.

They have reassigned senior scientists to paperwork and handed life-and-death risk assessments to staff with less experience. They have installed former chemical industry lobbyists to run the very offices that are supposed to regulate the chemical industry.

A gift to industry, paid for with your family’s health.

They are even throwing out research on how certain chemicals hit certain communities harder, calling decades of established science “DEI.”

You can make risk disappear on paper.

The cancer does not disappear.

The birth defects do not disappear.

The infertility does not disappear.

The kids drinking the water and getting sick do not disappear.

The EPA exists to protect people, not to protect the profit margins of the people poisoning them.

Every American deserves to know what is happening. #TrumpMakesUsSick

https://t.co/5DwXgxBybt

[Ann Bauer Sc.D. @AnnBauerZ]

Important yet overlooked study:
A Single Early-Life #Acetaminophen Exposure Causes Persistent Abnormalities in the Murine #Lung

Mice exposed to 1 dose of Tylenol (below that required for hepatic damage) at P14 revealed persistent abnormalities consistent with lung enlargement and alveolar simplification. A single exposure during this developmental window is enough to cause persistent functional and stereological abnormalities.

https://t.co/SEI0nZClpW

[Ann Bauer Sc.D. @AnnBauerZ]

There are 3 limitations of the sibling analyses of #acetaminophen which should preclude one from using them to make firm conclusions.

The most obvious issue is extreme exposure misclassification. These studies report 2-7% of women exposed when maternal reported studies in the same populations, during the time period, report over 55%. The studies with the best exposure assessments, using biomarkers to measure body burden of acetaminophen, consistently found strong effects (see graphic)

2) The current thinking on autism is genetic predisposition is required for a toxic exposure to lead to ASD. Therefore, genetics would be a mediator on the causal pathway. Sibling analyses treat genetics as a confounder which would bias results. https://t.co/uRhr8pL1jK

3) A substantial divergence in associations in the sibling bidirectional analyses indicates unaddressed sources of bias (in Ahlqvist too) https://t.co/JR4NKeHH1b

[Ann Bauer Sc.D. @AnnBauerZ]

@IntegralAnswers Please be aware that the valproate and autism association has also been attenuated to the null (showing no relationship) in a sibling control analysis. Corrected link: https://t.co/uOv1PWmbfN

[Paul Whiteley @PaulWhiteleyPhD]

"Some of the most relevant compounds detected by the theoretical model are amino acid and amino-acidic derivatives, volatile organic compounds, and short-chain fatty acids" https://t.co/yK5edDcqhy Wouldn't disagree with this. AI & gut metabolites in autism.

[Eric Topol @EricTopol]

The pro-inflammatory role of microglia is considered a key driver of Alzheimer's disease. Today @NeuroCellPress discovery of an epigenetic regulator of microglial mitochondria in the experimental model that may be amenable as a target for therapy or prevention
https://t.co/NXkEi59H8N

[Eric Topol @EricTopol]

The suppressed report that concluded there is no protective or safe level of alcohol consumption, now published. It was commissioned by US Congress
Report https://t.co/XmmsSo9q3q
Editorial https://t.co/8NuqBwkugM
"Despite the study’s adherence to its mandate, its findings were sidelined.”

[Paul Whiteley @PaulWhiteleyPhD]

"Maternal-fetal type 1 interferon may be a key factor in the association between maternal infection during pregnancy and having an autistic child, according to a new mouse study" https://t.co/O5AC2Qperl Careful with 'mouse study' but yes, immune functions are implicated for some.

[Ann Bauer Sc.D. @AnnBauerZ]

@KBr_enthusiast Important info. Thanks.

[Ann Bauer Sc.D. @AnnBauerZ]

#Breast #milk concentrations of #acetaminophen and diclofenac - UNEXPECTEDLY HIGH MAMMARY TRANSFER of the general-purpose drug ACETAMINOPHEN

“Given recent studies suggesting potential connections between acetaminophen use during pregnancy and risks to #developmental prognosis in children, we believe that adequate information regarding the fact that acetaminophen is easily transferred to breast milk should be provided to mothers.”

https://t.co/pzAARqIhVQ