Anna Monzel

Computational scientist | Cell biologist | Mitochondriac @columbiapsych. Studying mitochondrial diversity in the human body.

[Anna Monzel @AnnaMonzel]

MitotypeExplorer: an interactive web resource to explore mitochondrial molecular diversity in different tissues and under diverse experimental conditions

[Martin Picard @MitoPsychoBio]

If you want to explore your favorite mitochondrial gene, function, or pathway in different human tissues and organs, have a look at the first version of
https://t.co/KunIRe7DzP

Feedback welcome!

[Martin Picard @MitoPsychoBio]

Grateful to work with so many talented and passionate people to build the foundation for how we think about mitochondria, energy, health, and healing

Kudos @AnnaMonzel for coming up with the "motherboard" analogy

Thank you @janellison
https://t.co/MPIUrLRxJH

[Anna Monzel @AnnaMonzel]

Such a fun project! I enjoyed processing and mitotyping the single nuclei RNAseq data. Chapeau to Eugene, Ayelet, @MichelTdS, @MitoPsychoBio and all co-authors for creating the first MitoBrainMap 👏

[Martin Picard @MitoPsychoBio]

The brain is full of mitochondria!
But how many, and where?

Different types of mitochondria specialize for energy transformation and other functions

In MitoBrainMap v1.0 we provide the first maps of mitochondrial content and OxPhos capacity across the human brain

[Michel Thiebaut de S @MichelTdS]

🧠 Just out in Nature: A human brain map of mitochondrial diversity. A powerful collaboration with Mosharov and @MitoPsychoBio. Big step toward bridging cell biology and neuroimaging!
🔗 https://t.co/4X7PVKFsaU
🧬 #MitoBrainMap #neuroscience

[Anna Monzel @AnnaMonzel]

@MitoPsychoBio Revised version of the paper can be found here: https://t.co/FNuqcLbeIF
There was a rendering issue with some of the figures. Sorry about that!

[Martin Picard @MitoPsychoBio]

All mitochondria in your body comes from the same "mother" population in the egg/oocyte, later differentiating into distinct mitochondrial phenotypes or "mitotypes" (like cell types)

In the end, we are made of dozens of different specialized mitotypes

New preprint where @AnnaMonzel quantifies how different mitochondrial populations are in different organs and tissues, and within the same cell type exposed to different challenges over several months

https://t.co/Jlfi4MFwze

[Sam Payne @byu_sam]

Well. It REALLY happened. The plagiarized paper got published.

my paper from 2021 - https://t.co/F3740qBLpH
new one from 2024 - https://t.co/bmMXP4efvO

We'll look at figures in the 🧵 below.

[Nico Dosenbach @ndosenbach]

Psilocybin's powerful short- and long-term effects on your brain are revealed by this intrepid precision imaging drug trial published in @Nature. As one of the scientists I was also a study volunteer. Spending hours in an MRI scanner, while tripping on 25 mg was the experience of a lifetime. Ever since, it's fascinated me that I can remember all of it, even though my thoughts were massively distorted. I took notes afterwards and turned them into a story ... given the interest, I'll try to publish it somewhere.
Study: https://t.co/Go9u3ClDFn
NPR coverage: https://t.co/8bIqbIW3aR

[Anna Monzel @AnnaMonzel]

So important!

[Martin Picard @MitoPsychoBio]

Eudaimonic well being and a sense of connectedness may be among the most porweful experiences to shift our biology.

Important to study these experiences in relation to health and healing.

[Anna Monzel @AnnaMonzel]

Such great work!

[Helmholtz Munich | @HelmholtzMunich @HelmholtzMunich]

#Father's diet before #conception influences children's #health! When the father eats healthy, the risk of #obesity & #diabetes for his #children is reduced.

More about the study conducted by #HelmholtzMunich @epi_tep & @DiabResearch in our news:
👉https://t.co/MaNVyNfDYe

[Martin Picard @MitoPsychoBio]

Is brain mitochondrial biology linked to our positive and negative psychosocial experiences?

@CarolineTrumpff looked into this question using a brain multi-omic postmortem dataset from individuals who reported their subjective experiences yearly until they died.

[Martin Picard @MitoPsychoBio]

What is the Integrated Stress Response (ISR) ?

[Cell Metabolism @Cell_Metabolism]

#NewIssue On the cover: In this issue of Cell Metabolism, Li et al. reveal that sick neurons release lipids to the glia, causing lipid droplet accumulation and neuroinflammation. The artwork, inspired by Van Gogh's Starry Night, depicts a brain with lipid droplets. Artwork by Melody Hui.
Read the paper: https://t.co/aUmTNgNkEM

[Martin Picard @MitoPsychoBio]

Why are transitions always difficult?

Whether a conscious, thinking, feeling organism; or a single cell; life transitions are always hard because they cost energy.

We discuss the energetic cost of transitions, the ISR, and GDF15:
https://t.co/gvmpgN9tJL

[Xiaolei Liu @erin_liuxiaolei]

Perspective: ISR is an energetic checkpoint evolved to prevent OxPhos-deficient cells from engaging in excessively costly transitions, and allow ISR-positive cells to recruit systemic energetic resources.https://t.co/HzwEpVudGF

[Anna Monzel @AnnaMonzel]

Such an amazing resource for the world of mitochondria!

[Anna Monzel @AnnaMonzel]

Bravo!! Amazing work @n_bobba_alves , @MitoPsychoBio, and all co-authors!

[E-mit @Emit38935125]

Thank you so much of being part of #Euromit2023 ! We hope you enjoyed it ! See you at the next mito conference !

[Anna Monzel @AnnaMonzel]

Inspiring closing lecture by @AWartiovaara @Euromit2023

[E-mit @Emit38935125]

Columbia University family at #euromit2023