MitotypeExplorer: an interactive web resource to explore mitochondrial molecular diversity in different tissues and under diverse experimental conditions
If you want to explore your favorite mitochondrial gene, function, or pathway in different human tissues and organs, have a look at the first version of
https://t.co/KunIRe7DzP
Feedback welcome!
Grateful to work with so many talented and passionate people to build the foundation for how we think about mitochondria, energy, health, and healing
Kudos @AnnaMonzel for coming up with the "motherboard" analogy
Thank you @janellison
https://t.co/MPIUrLRxJH
Such a fun project! I enjoyed processing and mitotyping the single nuclei RNAseq data. Chapeau to Eugene, Ayelet, @MichelTdS, @MitoPsychoBio and all co-authors for creating the first MitoBrainMap 👏
The brain is full of mitochondria!
But how many, and where?
Different types of mitochondria specialize for energy transformation and other functions
In MitoBrainMap v1.0 we provide the first maps of mitochondrial content and OxPhos capacity across the human brain
🧠 Just out in Nature: A human brain map of mitochondrial diversity. A powerful collaboration with Mosharov and @MitoPsychoBio. Big step toward bridging cell biology and neuroimaging!
🔗 https://t.co/4X7PVKFsaU
🧬 #MitoBrainMap#neuroscience
@MitoPsychoBio Revised version of the paper can be found here: https://t.co/FNuqcLbeIF
There was a rendering issue with some of the figures. Sorry about that!
All mitochondria in your body comes from the same "mother" population in the egg/oocyte, later differentiating into distinct mitochondrial phenotypes or "mitotypes" (like cell types)
In the end, we are made of dozens of different specialized mitotypes
New preprint where @AnnaMonzel quantifies how different mitochondrial populations are in different organs and tissues, and within the same cell type exposed to different challenges over several months
https://t.co/Jlfi4MFwze
Well. It REALLY happened. The plagiarized paper got published.
my paper from 2021 - https://t.co/F3740qBLpH
new one from 2024 - https://t.co/bmMXP4efvO
We'll look at figures in the 🧵 below.
Psilocybin's powerful short- and long-term effects on your brain are revealed by this intrepid precision imaging drug trial published in @Nature. As one of the scientists I was also a study volunteer. Spending hours in an MRI scanner, while tripping on 25 mg was the experience of a lifetime. Ever since, it's fascinated me that I can remember all of it, even though my thoughts were massively distorted. I took notes afterwards and turned them into a story ... given the interest, I'll try to publish it somewhere.
Study: https://t.co/Go9u3ClDFn
NPR coverage: https://t.co/8bIqbIW3aR
Eudaimonic well being and a sense of connectedness may be among the most porweful experiences to shift our biology.
Important to study these experiences in relation to health and healing.
Is brain mitochondrial biology linked to our positive and negative psychosocial experiences?
@CarolineTrumpff looked into this question using a brain multi-omic postmortem dataset from individuals who reported their subjective experiences yearly until they died.
#NewIssue On the cover: In this issue of Cell Metabolism, Li et al. reveal that sick neurons release lipids to the glia, causing lipid droplet accumulation and neuroinflammation. The artwork, inspired by Van Gogh's Starry Night, depicts a brain with lipid droplets. Artwork by Melody Hui.
Read the paper: https://t.co/aUmTNgNkEM
Why are transitions always difficult?
Whether a conscious, thinking, feeling organism; or a single cell; life transitions are always hard because they cost energy.
We discuss the energetic cost of transitions, the ISR, and GDF15:
https://t.co/gvmpgN9tJL
Perspective: ISR is an energetic checkpoint evolved to prevent OxPhos-deficient cells from engaging in excessively costly transitions, and allow ISR-positive cells to recruit systemic energetic resources.https://t.co/HzwEpVudGF