Arbely Lab

Biochemistry and synthetic biology lab at Ben-Gurion University of the Negev.

[Arbely Lab @ArbelyLab]

🎉 Huge congratulations to first author @Fang_WU_ (@bengurion) and to our wonderful collaborators Alejandro Villagra (@Georgetown) and Cyril Bařinka (@BIOCEV_science) for the rigorous work. Thrilled to see this one out. Thank you all 🙏

#HDAC6 #SSAT2 #ChemBio #Metabolism #PTM

[Arbely Lab @ArbelyLab]

🧵 What does the mysterious first catalytic domain of HDAC6 do?
After 20 years, we have an answer, and it validates a metabolic hypothesis first proposed in 1943.

New preprint from our lab on bioRxiv (1/8) 👇
https://t.co/NwnTL2vU7u

[Arbely Lab @ArbelyLab]

Bottom line: PTMs are not only protein marks. Free modified amino acids can be signaling metabolites that couple metabolism, proteostasis, and human genetics. (7/8)

[The Banfield Lab @BanfieldLab]

🚨 We discovered a new genetic code, "Genetic Code 34," sporadically distributed in archaea. Select archaea have genome-wide recoding of the TAG stop codon to pyrrolysine; the adoption of this code was likely driven by metabolic processes. (1/2) https://t.co/wzEKFpSPxE

[Scripps Research @scrippsresearch]

The lab of @AhmedHBadran has expanded the genetic code by incorporating non-canonical amino acids using four-nucleotide codons. Published in @NatureBiotech, this method enhances #proteinsynthesis precision for drug discovery. More: https://t.co/IJSQxH09M8

[ChristiansonLaboratory @ChristiansonLab]

Congrats to postdoc Juana Goulart Stollmaier @jubsnjubs and group alum Dr @ParisRWatson for this fantastic work, just published in ACS Med Chem Lett @ACSBioMed! HDAC10 catalyzes thioester hydrolysis to activate thiol-containing pharmacophores.
https://t.co/vJxYeFOSVW

[Arbely Lab @ArbelyLab]

@RegevW @Fang_WU_ @TheEliaLab @roi_gazit Thanks Neta

[Arbely Lab @ArbelyLab]

We are excited to share our new preprint, describing G6PD acetylation-dependent activity and crosstalk with apoptotic signaling cascades. Congrats to @Fang_WU_, who led the project (almost) single-handedly, and collaborators @TheEliaLab and @roi_gazit 1/7 https://t.co/H1LTdARv5H

[Arbely Lab @ArbelyLab]

@LabTzur @Fang_WU_ @TheEliaLab @roi_gazit Thanks, Yonatan!

[Arbely Lab @ArbelyLab]

@Hod_Lab Thanks, Idan

[Arbely Lab @ArbelyLab]

@at_bgu Thanks, Menny

[Arbely Lab @ArbelyLab]

These and other findings described in the manuscript, can be summarized in a mechanistic model for the functional implications of G6PD K89 and K403 acetylation. 7/7

[Arbely Lab @ArbelyLab]

We also found that G6PD K403 acetylation promotes Y503 phosphorylation, interaction with p53 (A), and p53-dependent induction of apoptotic signaling cascades (B, C). 6/7