Arun Chavan

Postdoc at @Yale.
Evo-devo, zoology, cell types, et cetera.

[Deepak Modi @DeepakNModi]

Hot from the lab. our preprint showing that embryo implantation requires #inflammation that is controlled by HOXA10, and dysregulation of the HOXA10-inflammation axis is associated with #miscarriage
https://t.co/rrmUn7mb2T
@ponsankaran_r @Sharmishth38157 @icmrnirrch @ICMRDELHI

[Deepak Modi @DeepakNModi]

Thrilled to share our discovery of the genetic switch that creates a hybrid EMT state in the uterus for the first step in embryo implantstion.
A fantastic team work with @mkjolly15 and @shrutihansda to discover the teams
@icmrnirrch @iiscbangalore
https://t.co/7aGZx5MVqb

[Viki Male @VikiLovesFACS]

Have you ever wondered why embryo implantation should be a (sort of) inflammatory process? This paper compares implantation in marsupials and three haemochorial eutherian mammals to try to answer that question.

https://t.co/aBN793rvwd

[Shelli Farhadian @ShelFarFar]

Glad to share our study on placental changes during maternal SARS-CoV-2 infection, done in collaboration with @VirusesImmunity and led by @aliceluculligan.

[Shelli Farhadian @ShelFarFar]

Many thanks to our generous research participants, Yale IMPACT team, @PiviVijayakumar @ArunRChavan @LinaIrshaidMD @VogelsChantal @NathanGrubaugh @ericsongg @AJMooreHealth @FeimeiL @aaronmring @LizaKonnikova and many not on Twitter

[Arun Chavan @ArunRChavan]

@reject_resubmit lymph nodes

[Arun Chavan @ArunRChavan]

@OliGriffith @AJ_Pask @DevoEvoMed @CharlieFeigin @EvoDevoPanAm This is probably already on your radar, but Quirks of Human Anatomy by Lewis Held has nice case studies of evo-devo of human anatomy.

[Arun Chavan @ArunRChavan]

@RuthFranklinLab Thanks, Ruth! :)

[Arun Chavan @ArunRChavan]

We show how embryo implantation evolved in placental mammals via modification of an ancestral mucosal inflammatory response; & that this was enabled by decidual cells, a cell type that originated in the placental lineage. Now out in MBE of @OfficialSMBE: https://t.co/mPJrx72pXE

[Arun Chavan @ArunRChavan]

@koryu_kin @OfficialSMBE Thanks, Koryu!

[Arun Chavan @ArunRChavan]

This was a collaboration with @OliGriffith, @JamieMaziarz, @LeeKoren2, and others at @yale_eeb.

Preprint here: https://t.co/xezofvYxAk

[Arun Chavan @ArunRChavan]

In this preprint, we show how embryo implantation evolved by modification of an ancestral inflammatory response. https://t.co/gYBAsJDKi9

[Arun Chavan @ArunRChavan]

@TomDoesScience @em_quinones @dsmithparedes @jasmina_wiemann @florsheim_eb I don't think I have heard of any, but may be some departments have their own?

[Oliver Griffith @OliGriffith]

The opossum has maternal recognition of pregnancy. Check out our new paper in @RSocPublishing's Proceedings B. https://t.co/KrkAx6XpKs

[Arun Chavan @ArunRChavan]

One module of inflammation (neutrophil recruitment by cytokine IL17A) was turned off in placental mammal pregnancy; and this was enabled by a novel placental mammal cell type, decidual cells. – with @OliGriffith, @JamieMaziarz, @LeeKoren2, and others.

[Arun Chavan @ArunRChavan]

In this preprint, we show how embryo implantation evolved by modification of an ancestral inflammatory response. https://t.co/gYBAsJDKi9

[Arun Chavan @ArunRChavan]

@3rdreviewer @Johri_Parul Congrats Parul!!

[Oliver Griffith @OliGriffith]

New paper out today investigating the re-evolution of fingers and toes in skinks from the Philippines. https://t.co/ndxBtVzkGs

[Jasmine Mah @[email protected] @jasminelmah]

The latest from the Leys lab: in situ recordings show that glass sponges stop pumping - like holding one's breath - when exposed to sediment in the sponge reefs. https://t.co/OkKecYDvOG

[Arun Chavan @ArunRChavan]

@jrossibarra Haha, neither! Sigh/Psi

[Arun Chavan @ArunRChavan]

Sigh. https://t.co/7U6dwcdu0P

[Jeffrey Ross-Ibarra @jrossibarra]

Decided today we would use Ψ for a confusing parameter since it’s the closest Greek letter to ¯\_(ツ)_/¯