Austin Reed

PhD student at WTKLAB @UnivCampharm / @SCICambridge with @cambridge_uni

[Austin Reed @AustinDReed]

Its finally here! I am excited to announce our paper on the Human Breast Cell Atlas is live now at @NatureGenet! A massive thank you to everyone involved particularly my amazing co-author @Dr_SaraPensa, project leads @WTKLAB and @MarioniLab and the @BreastCancerNow tissue bank!

[Walid Khaled @WTKLAB]

I am pleased to share the final version of our Human Breast Cell Atlas with @MarioniLab now out @NatureGenet. There are important new additions, which I will leave to @Dr_SaraPensa and @AustinDReed to mention👇 . Couple of points i want to highlight 👇:
https://t.co/tMCyMRJAdh

[Sara Pensa @Dr_SaraPensa]

We are forming a patient advisory group to help shape our research on BRCA breast cancer prevention! Follow the link/scan the barcode for more info and to express interest. Please RT! @WTKLAB
https://t.co/2qRVu73WqX

[Colinda Scheele @ColindaScheele]

📢Paper alert: We used #3Dpathology and CNVseq to understand the evolution of #precancer in the #humanbreast 🔬🧬Pre-malignant breast transformations develop within mutant clonal fields of morphologically normal-looking ducts 📰:https://t.co/B3msD1jspu
🏥: @vib_ccb @NKI_nl

[Cancer Discovery @CD_AACR]

Read Cancer Discovery's #ResearchWatch:
A Single-Cell Atlas Uncovers Cellular Dynamics of the Human Breast, summarizing the work of @AustinDReed, @Dr_SaraPensa, @MarioniLab, @WTKLAB et al.
https://t.co/oT1cUbl3X1
@univcampharm @SCICambridge

[Camila dos Santos @caoresco]

Check out our new work!!!

[Nature Portfolio @NaturePortfolio]

A paper in @NatureGenet reports on a single-cell RNA sequencing analysis of over 800,000 human adult breast cells, which identifies 41 cell subtypes and highlights age- and parity-dependent effects. https://t.co/K0VvjPeMzN

[Walid Khaled @WTKLAB]

Here is a research briefing @NatureGenet explaining our the story behind the Atlas.

https://t.co/CsKGSGgIcH

[Austin Reed @AustinDReed]

@Dr_SaraPensa @WTKLAB @CRUKresearch @CRUKCamCentre @Cambridge_Uni @CRUK_CI @SCICambridge @UnivCamPharm @EarlyCancerCam To extend the utility of our resource, we additionally present the first integrated HBCA of 2.1M cells. From the iHBCA we have trained a suit of CellTypist label transfer models to allow quick and easy cell type annotation in your own datasets! Have a try! https://t.co/rADkoHqihs

[Austin Reed @AustinDReed]

@WTKLAB @Dr_SaraPensa @CRUKresearch @CRUKCamCentre @Cambridge_Uni @CRUK_CI @SCICambridge @UnivCamPharm @EarlyCancerCam One of our key findings from the HBCA was that women carrying BRCA1 and BRCA2 mutations have a significantly increased presence of immune cells in the breast.

[Austin Reed @AustinDReed]

@WTKLAB @Dr_SaraPensa @CRUKresearch @CRUKCamCentre @Cambridge_Uni @CRUK_CI @SCICambridge @UnivCamPharm @EarlyCancerCam Our HBCA captures the cellular heterogeneity of the resting breast and characterises the many changes imparted by age, parity and germline BRCA1/2 mutations at a cellular level. Have a look at our previous thread on the bioRxiv for more details!

[Austin Reed @AustinDReed]

Super excited to be sharing the preprint for my first paper alongside co-author @Dr_SaraPensa with help from many others across @WTKLAB and @MarioniLab! A massive thank you to everyone who made it all possible!

[Walid Khaled @WTKLAB]

I am very pleased to share our second and largest contribution to “The Human Breast Cell Atlas” (HBCA) project. Buckle up a longish thread ahead!

https://t.co/hEmnIJKNsr

[Austin Reed @AustinDReed]

@simocristea @WTKLAB @UnivCamPharm Not sure yet on release date, but we have patients from a wide range of differing age, parity and menopause status included!

[Austin Reed @AustinDReed]

@VijayachandraK @WTKLAB @UnivCamPharm Thank you! They are ‘normal’ mammary epithelial cells for all patients