Axel Janssen

Postdoctoral researcher in the @DMF at @UNIL. Opinions my own. Mastodon: @[email protected]. Bluesky:

[MV Mazzuoli @MVMazzuoli]

OUT NOW! 👇🏼We built a make-or-break Prime editing tool—have a read to discover how it’s changing the way we do genomic engineering.

https://t.co/3XyNoWfulS

@JWVeening @AxelJans & all others authors! 👏🏻

[Jan-Willem Veening @JWVeening]

Checkout @Bevika2 preprint! She used CRISPRi-seq to determine antibiotic-stress signatures, specifically of pneumococci treated with fluoroquinolone antibiotics. It's a really powerful approach revealing a surprising antibiotic combination therapy. 1/9 https://t.co/ClAZgaJokO

[Axel Janssen @AxelJans]

Again, thanks to all co-authors for their work on this as well, and other Veening lab members for their continued feedback and bug reports.

[Axel Janssen @AxelJans]

Do you use D39V, TIGR4, EF3030, BHN418, or another pneumococcal strain in your research? Easily browse their genome on PneumoBrowse 2 https://t.co/oje9m9llAn! Now out in shiny PDF in Nucleic Acids Research!

Do you have any feedback? Please let us know!

https://t.co/4t70yOkdl8

[Jan-Willem Veening @JWVeening]

Happy to announce PneumoBrowse 2! Access it here: https://t.co/nyx9188snS and read the preprint here:
https://t.co/jfQN9yxGN5

[Axel Janssen @AxelJans]

We have now also added the ability to view pair-wise genome alignments to PneumoBrowse2.

Find this option in the "Linear Synteny" or "Dotplot" alignments views (bottom), or in separate data tracks (per genome).

Thanks for the excellent reviewer comments on this.

[Alexander Harms @AHarms485]

You are looking for a PostDoc position or know someone who is? We are looking for someone to join our team at @ETH_en Zürich for a project on phage-host interactions of Pseudomonas aeruginosa 🦠🧬👇🏼

[Dunn_School (now @DunnSchool.bsky.social) @Dunn_School]

New job opportunity 📢

Associate professor, immunity/inflammation/infection (defined broadly) especially welcome

Come and join a great community of supportive colleagues!

Deadline 25 October, please spread the word

https://t.co/ebjdr6hPGp

[NCCR AntiResist @NCCR_AntiResist]

We are delighted to announce we @NCCR_AntiResist are funding a four-year PhD position with the Boeck lab in Infection Biology, focusing on pulmonary Pseudomonas aeruginosa infections using genomic and large-scale wet lab technologies.

👉Read more: https://t.co/wLisZaEcCA

[Axel Janssen @AxelJans]

@JulDenereaz If you are interested in pneumococcal strains D39V, EF3030, BHN418, TIGR4, or one of the PMEN reference strains, you can check out the genomes interactively in PneumoBrowse 2!

Go straight to PneumoBrowse 2: https://t.co/oje9m9llAn

[Axel Janssen @AxelJans]

I definitely recommend to check out our work on make-or-break prime editing, but also our newest edition of PneumoBrowse! But don't sleep on @JulDenereaz's great dual CRISPRi-Seq work!

(Spoiler: I am on the author list of the first 2 papers)

[Jan-Willem Veening @JWVeening]

ICYMI: 3 new preprints from the lab:
1) Make-or-Break Prime editing: the most elegant bacterial genome editing tech to date
2) PneumoBrowse2.0: Revamped pneumococcal genome browser
3) Dual CRISPRi-seq: One of the most comprehensive genetic interaction study in bacteria ever

[Jan-Willem Veening @JWVeening]

2) PneumoBrowse2.0: Revamped pneumococcal genome browser
https://t.co/jfQN9yxGN5

[Jan-Willem Veening @JWVeening]

1) Make-or-Break Prime editing: the most elegant bacterial genome editing tech to date
https://t.co/BgEukZCIWR

[Jan-Willem Veening @JWVeening]

ICYMI: 3 new preprints from the lab:
1) Make-or-Break Prime editing: the most elegant bacterial genome editing tech to date
2) PneumoBrowse2.0: Revamped pneumococcal genome browser
3) Dual CRISPRi-seq: One of the most comprehensive genetic interaction study in bacteria ever

[Jan-Willem Veening @JWVeening]

Genome-wide dual CRISPRi-seq! Knocking down every gene with every other gene in the pneumococcus, identifying > 4000 genetic interactions (GIs), most of which have never been reported. https://t.co/LNFfnoNAcY

[bioRxiv Microbiology @biorxiv_micrbio]

Dual CRISPRi-Seq for genome-wide genetic interaction studies identifies key genes involved in the pneumococcal cell cycle https://t.co/vmlmppxAxl #biorxiv_micrbio

[ASM @ASMicrobiology]

Introducing Bacttle! A board game targeting players in primary school that showcases the life of microbes. From basic concepts of environmental microbiology to motility & biofilm formation, the game aims to increase knowledge about bacteria. #JMBE: https://t.co/7UK91MXUID

[Jan-Willem Veening @JWVeening]

PneumoBrowse 2 is freely available on https://t.co/u98kPDPLoV. Many thanks to the entire lab for keeping track of updates and literature and specifically @AxelJans @PaddyGibson2 @afonsbravo @vincentdebakker @JelleSlager for putting it all together and @doranpauka for IT support!

[Jan-Willem Veening @JWVeening]

Happy to announce PneumoBrowse 2! Access it here: https://t.co/nyx9188snS and read the preprint here:
https://t.co/jfQN9yxGN5

[Sara Mitri @saramitri]

We're looking for an enthusiastic experimentalist PhD student to join our interdisciplinary group interested in the ecology & evolution of microbial communities https://t.co/s2x7ncXcWZ. Apply https://t.co/4cV3n2ti0x before Aug 31! Bonus: Lausanne is a beautiful place to live!