B@k

[Donald J. Trump @realDonaldTrump]

TO MY GREAT FELLOW AMERICANS…

[Crypto Rover @cryptorover]

We’ve seen the harshest Fed quantitative tightening in Bitcoin’s history.

Yet the price still rallied from $15K to $124K.

Now imagine what happens once quantitative easing begins.

[Sentay @DziebanyPet]

Gówno widze

[Elon Musk @elonmusk]

Wow, this is cool 😎

[Phil Konieczny @PhilKonieczny]

Stany zjednoczone oficjalnie tworzą narodową rezerwę w postaci Bitcoina.
Jeszcze pare lat temu bym powiedzial, że to nie jest realne by kraje używały BTC jako store of value.
To pokazuje ogromny potencjał wzrostowy BTC na przestrzeni kolejnej dekady.
Kiedy Polska to zrobi?

[Morris Monye @Morris_Monye]

I’ve been crying with laughter all morning. 😂😂😂

[B@k @BakBezRak]

@RadioGenoa Fuck no!

[Elon Musk @elonmusk]

Make Europe Great Again!

MEGA, MEGA, MEGA

[Barry Cunningham @barrycunningham]

HERE'S THE "CLEAN" VERSION OF FAFO!

[B@k @BakBezRak]

@AlexSzyszynka Polecam jednak sprawdzone źródła
https://t.co/BzwwYKH4rG

[Vance 🌞⚡️ @VanceE]

Methylene Blue vs Low Vitamin A

[BowTiedNeuron | Neuroscientist @BowTiedNeuron]

Update:

After just one dose I already prefer this to the first Saffron extract I used

This one felt more dopaminergic, supporting more and focus, whereas I couldn’t focus when I used the one from Nootropics Depot

On top of that, I noticed mildly reduced hunger throughout the day. It was still there, just not as intense in the time leading up to lunch or my 3rd meal

Overall, the difference in effect profiles between this and the extract from ND is much greater than I expected

Both produce a nice boost in mood, but the one from Notable also supported focus which is the opposite of what the ND one did for me

This experience was on a 60mg dose (2 caps)

I’ll keep experimenting with it until I eventually drop a full review

[NootBro @nootropicguy]

Big Pharma doesn’t want you to know about Saffron

- As effective as Ritalin in ADHD
- As effective as Prozac in Depression
- As effective as Celexa in Anxiety
- As effective as Luvox in OCD
- As effective as Donepezil in Alzheimer’s

Also:

- Reverses SSRI sexual dysfunction
- Reduces opioid withdrawal/tolerance
- Reduces appetite/hunger up to 69%
- Enhances neurogenesis via BDNF
- Reduces neurotransmitter breakdown
- Boosts dopamine levels (DRI)
- Directly boosts dopamine release
- Boosts noradrenaline levels (NRI)
- Boosts acetylcholine (AChE inhibitor)
- Antioxidant & anti-neuroinflammation
- Boosts melatonin (circadian enhancer)
- Enhances sleep (via GABA-A & NMDA)
- Enhances mitochondrial function & ATP
- Proven to improve macular degeneration

Extremely few natural supplements with as many benefits

I’ve personally been taking 60mg regularly since 2021

Definitely adds a mild but noticeable euphoric kick especially when combined with coffee or other stimulants

Highly recommend

[Vance 🌞⚡️ @VanceE]

Joe Rogan and Mel Gibson talking about anti-parasitic compounds working on cancer.

Ivermectin, Fenben, Methylene Blue.

[B@k @BakBezRak]

@poprawmakijaz Serio 🤣🤣🤣🤣 chciała się zeszmacic a uczestnicy dali jej dokładnie to czego chciala. Nie widzę powodu żeby tu kogokolwiek żałować

[B@k @BakBezRak]

#NoweZdjecieProfilowe

[Based @BasedSupps]

Common reported side effects of Butea Superba:

- Inexplicable confidence
- Unwanted female attention
- Crazy pumps
- Controlled aggression

Use at your own risk

[NootBro @nootropicguy]

98% of brain boosters give you ZERO noticeable benefit

Polygala Tenuifolia is one of the exceptions

In fact, I’ve been taking it almost daily for the past 2 years

Why?

It’s one of the few ingredients that you can actually FEEL

- Enhanced motivation
- Rapid antidepressant
- Sharper memory

Here’s exactly how it works:

1. IMPROVES FOCUS & MOTIVATION

Polygala quickly & significantly increases levels of

1) Dopamine (more motivation)
2) Norepinephrine (attention)

It does this via inhibiting:

- Dopamine & NE reuptake
- Monoamine oxidase enzymes

It does this without the typical stimulant-induced jitters or insomnia

In fact, studies have shown it actually improves sleep quality…

2) RAPID ANTIDEPRESSANT

Polygala has been shown to exert rapid antidepressant effects

This is because Polygala blocks NMDA receptors & quickly increases levels of BDNF in the brain

Think Ketamine, but without the side effects

These mechanisms also contribute:

- MAO inhibition
- Monoamine reuptake inhibition
- Anti-neuroinflammatory effect

3) ENHANCES MEMORY

Polygala can also increase levels of acetycholine, the memory neurotransmitter

It does this by preventing the breakdown of acetycholine (via AChE enzyme inhibition)

But it even goes a step further by enhancing enhancing choline acetyltransferase (ChAT)

ChAT is the enzyme that facilitates acetylcholine synthesis

It even upregulates nAChR7 expression

This is the receptor responsible for nicotine’s cognitive-enhancing effect (not its addictive effect)

A human clinical trial has confirmed Polygala enhances spatial, verbal, & working memory

Another human trial showed it enhanced cognition in the elderly

4) PREVENTS NEURODEGENERATION

Researchers have explored using Polygala to treat neurodegenerative conditions like Alzheimer’s

Polygala not only boosts acetylcholine like the go-to Alzheimer’s drug Donepezil

But it also reduces neuroinflammation & oxidative stress, two key factors in neurodegeneration

- Boosts SOD (antioxidant enzyme)
- Blocks NF-kB pathway
- Lowers cytokines (TNF-a, IL-1b)

On top of all of this, Polygala can directly block production of neurotoxic beta amyloid proteins seen in Alzheimer’s

5) HELPS TO REGROW THE BRAIN

Polygala is a step ahead of current Alzheimer’s drugs though

That’s because it can actually help to regrow the brain

It does this by increasing levels of key neurotrophic factors such as BDNF & NGF

BDNF & NGF are essentially “steroids for your brain” and literally help regrow the brain

Polygala also upregulates the BDNF receptor: TrkB

Three birds, one stone

Several studies have confirmed Polygala promotes neural stem cell proliferation & neurite outgrowth

Highly recommend trying this one out

Would take a month off every 2-3 months or so

[Noah Ryan @NoahRyanCo]

NAC consistently outperforms pharmaceuticals for treating mental health disorders and the FDA wants to ban it:

- Improves social interactions in autistic children
- Reduces drug seeking behavior in PTSD rats
- Reduces OCD behavior as good as SSRIs
- Improves functioning in schizophrenics

A few reasons why...

1. NAC replenishes glutathione in the brain better than glutathione.

Neuroinflammation has long been linked to mental health disorders. It disrupts delicate neurotransmitter balances, damages neurons, hinders the blood-brain barrier (BBB), and puts your brain's immune cells (microglia) on high alert.

More glutathione = less inflammatory damage

2. NAC regulates glutamate

Glutamate dysregulation leads to excitotoxicity, damaging neurons. NAC prevents overstimulation of neurons by regulating glutamate levels in the synapses

3. NAC modulates dopamine

Dopamine dysregulation is a primary culprit behind schizophrenia and addiction. NAC has shown to reduce cravings and compulsive behaviors by normalizing dopamine signaling in brain regions associated with reward.
4. NAC Boosts mitochondrial function

Your brain is one of the most metabolically active organs in your body. Neurons rely heavily on ATP produced by your mitochondria.
Your mitochondria are heavily susceptible to oxidative stress. They don't have the same repair mechanisms as the rest of our organelles (different DNA). NAC reduces oxidative stress within mitochondria by scavenging free radicals and replenishing intraceullular glutathione. It protects your mitochondria's fragile DNA and improves mitochondrial efficiency.

Better mitochondria = Better brain energy production.

Dosing & Side Effects:

I started taking NAC to repair my liver after accutane. I continue taking it because it clears my head. It lets me fall into focus without fixating on how dirty my floors are or that parking ticket I haven't paid yet.

All of these brain benefits are amplified by NAC's impact on Phase 1 & 2 detox functions. NAC protects two of the body's most vital organs, the ones most damaged by modern toxicity.

I take 600mg-1200mg a few times a week. Especially before drinking and whenever I have brain fog/ruminating thoughts.

NAC may deplete copper, so cycle and prioritize dietary copper sources.

[BowTiedNeuron | Neuroscientist @BowTiedNeuron]

Simple yet Effective Neuroprotection Stack:

- Huperzine A (AchEI & NMDAR antagonism)
- Magnesium (NMDAR blockade)
- Taurine (GABA/Glycine agonism & Ca2+ regulator)
- Agmatine Sulfate (NMDAR antagonism & nNOS inhibition)
- L-Theanine (AMPA antagonism & glutamine uptake inhibition)

Cholinergic activity itself is neuroprotective, which is why other AchEIs (Donepezil & Galantamine) are used to treat Alzheimers.

Because of that, any cholinergic nootropic or herb (nicotine, bacopa, etc) can replace Huperzine, although its NMDA antagonism is a nice benefit.

Otherwise, the rest of this stack works to decrease glutamate signaling or increase GABA signaling which protects against glutamate induced excitotoxicity directly.