Correct answer: B) Nitrates
Nitrates are most commonly associated with postural (orthostatic) hypotension because they cause significant venodilation, reducing venous return (preload). This effect can be particularly pronounced when the patient suddenly stands.
⬜ Nitrates: prominent postural hypotension
🟨 Alpha-blockers: also classically associated with postural hypotension, especially the first-dose effect
⬛ Beta-blockers: may contribute, but less commonly
🟪 ACE inhibitors: generally have a lower risk
🟩 Calcium channel blockers: can cause hypotension, but postural hypotension is less characteristic
A 20-year-old woman with a history of recurrent unprovoked DVT presents with sudden severe abdominal pain, dyspnea, headache, and confusion.
Within 48 hours, her condition deteriorates dramatically. She develops hypoxemic respiratory failure, acute kidney injury, thrombocytopenia, painful purpuric skin lesions, and shock requiring ICU admission.
What is the diagnosis ⁉️
Can we ever stop anticoagulation after successful AF ablation?
ESC 2024: OAC for ≥2 months in everyone, then anticoagulation according to stroke risk — not apparent ablation success
ALONE-AF & OCEAN challenging the dogma👇
OAC = DOAC or VKA
#AFib#Ablation#Anticoagulation
@Hragy Some institutions allow PhD candidates to combine research with ongoing clinical work. While this may come with certain challenges, I greatly valued the opportunity to stay closely connected to clinical practice throughout my PhD.
Iron deficiency in heart failure: easy to miss, important to treat
🔹 Normal Hb does NOT exclude iron deficiency
🔹 ferritin + TSAT
🔹 IV iron improves symptoms/QoL — I
🔹 Reduces HF hospitalizations —IIa
🔹 Mortality benefit Not proven
#HeartFailure#Cardiology#HFrEF#ESC
👉 In 2026, LAAC has shifted from a “competing therapy” to a patient-specific alternative, with outcomes highly dependent on baseline bleeding risk and clinical context.
f, 74, BMI 23, resistant systolic hypertension, 200 on Telmisartan 80, HCTZ 25 and amlodipine 5.
Added Spironolactone 25 mg, patient nearly fainted next day!
Now on monotherapy Aldactone 25 for second week, what is this?