Basler Lab

Unraveling the secrets of bacterial injection needles .. (among other things)

[Basler Lab @Basler_Lab]

Congrats to @ATejadaArranz & the team for showing that Pseudomonas forms distinct subpopulations during infection, each damaging host tissue by a different mechanism.
Toolbox: single-cell microscopy, 3D image segmentation, high-sensitivity mass spec:
https://t.co/1ngf9Qrx2f

[Basler Lab @Basler_Lab]

When Pseudomonas is attacked, it strikes back!
Outer membrane damage triggers a tit-for-tat T6SS retaliation via TagQ/TagR protein complex assembly, activating the PpkA kinase.
Congrats to Maxim & team for uncovering this fascinating mechanism!
https://t.co/ouK2bah0Zj

[Basler Lab @Basler_Lab]

In our new paper, we uncover how Burkholderia switches from antibacterial T6SS-1 to eukaryotic-targeting T6SS-5. Surprisingly, actively turning off T6SS-1 assembly prevents mitochondrial damage and apoptosis.

Congrats @christy_chc and the team!

https://t.co/hyAkh8J9Nw

[Basler Lab @Basler_Lab]

Interested in the Function and Regulation of #T6SS? Do you have relevant experience from your Master's project? Apply to this PhD position in our lab:
https://t.co/2cnF90exE6

[Basler Lab @Basler_Lab]

Thanks #Gemini for making this possible!
Source codes are here:
https://t.co/xmZ7K4Bx0b
https://t.co/KbYV3IeoST

[Basler Lab @Basler_Lab]

A Garmin watch face with a living microbial battlefield powered by your daily stats that is never the same! 🦠⌚️

The BacFighT6 Watch Face runs a live, #T6SS mediated bacterial simulation on your wrist.

https://t.co/FUTxE7VaF4

[Basler Lab @Basler_Lab]

A standalone Garmin watch App to explore simple simulations on your wrist:
https://t.co/WwfXh1oRpn

[Basler Lab @Basler_Lab]

Thanks #Gemini for making this possible and super fast to develop!

[Basler Lab @Basler_Lab]

Turn your phone into a bacterial battle ground! 🦠📱

The new BacFighT6 Android app is both a simulation playground AND a Live Wallpaper. Customize cell parameters, tweak visuals, and watch #T6SS battles evolve right on your home screen!

Download here: https://t.co/VsD4RbZspW

[Basler Lab @Basler_Lab]

If Prey produces enough diffusible toxin, they kill everyone. They pay a high price for synthesis and lysis-dependent release of their toxin.
https://t.co/Dsb7bJUQM4

[Basler Lab @Basler_Lab]

New version of BacFighT6!
https://t.co/UTBM4lHefn

Diffusible toxins produced by prey to impact interactions of Attackers, Defenders and Prey!

This can make #T6SS battles interestingly unstable. Like this simulation with no winner after 100k steps:
https://t.co/6mIZLq21jl

👇

[Basler Lab @Basler_Lab]

After another slight increase in the toxin production rate, you get a long battle between Attackers and Prey.
https://t.co/Vb5nAyP7L4

[Basler Lab @Basler_Lab]

Congratulations to Alea on winning a Gold Medal🥇and a trip to the Taiwan International Science Fair!

The 4th top prize in a row under our mentorship. Huge thanks to @biozentrum, @NCCR_AntiResist, @UniBasel_en for their continuous support.

Read more:
https://t.co/j6UGeUGSpc

[Basler Lab @Basler_Lab]

Check this video describing Alea's high-school graduation project done in our lab:
https://t.co/13NqUk40th

Thanks to @biozentrum and @NCCR_AntiResist for support.

[Basler Lab @Basler_Lab]

Thank you, Katrin (@biozentrum) for a great summary of our paper!

You can also check out this "Behind the Paper" written by @ATejadaArranz:
https://t.co/U92SJ1xQe1

[Biozentrum, University of Basel @biozentrum]

New research by @Basler_Lab reveals a surprising microbial trade-off: The bacterium Pseudomonas aeruginosa activates a general defense program to survive “speargun” attacks from rival bacteria, but this defense makes it more vulnerable to antibiotics. 👇https://t.co/KG8v21A5hE