Barry Scott

Scientist-in-training | Retired quantitative trader | Hobbies 🚵🏼‍♂️⚽️⛷
@bazfscott.bsky.social

[Barry Scott @BazFScott]

New open-access review out in JPET (final version-of-record): Lac-Phe (N-lactoyl-phenylalanine) 🏃🍽️🧠
A signalling metabolite that rises after exercise + meals and links metabolism to appetite/energy balance.

https://t.co/dMGuLBt37Z

[Barry Scott @BazFScott]

Great to see this out — congrats to the whole team.

Nice to contribute on the human datasets — all analysis, no snakes 🐍

[Long Lab @longlabstanford]

The first approved GLP1 (Byetta) came from a desert reptile, the Gila monster. Inspired by this, our work on Burmese pythons 🐍🐍 is now out @NatMetabolism. An “extreme”-ly fun collaboration with Leinwand and @DrYongXu1. Congratulations @Shuke_Xiao!
https://t.co/Qwqd71JQYb

[Barry Scott @BazFScott]

@iampeteroni @RourkeLab Big thanks to @HankirMohammed for the guidance and for leading the neuroscience/appetite section. 🙏

[Barry Scott @BazFScott]

New open-access review out in JPET (final version-of-record): Lac-Phe (N-lactoyl-phenylalanine) 🏃🍽️🧠
A signalling metabolite that rises after exercise + meals and links metabolism to appetite/energy balance.

https://t.co/dMGuLBt37Z

[Barry Scott @BazFScott]

Translation is moving 🚀 First human Lac-Phe trial began dosing in 2025.

Open gaps: targets/receptors, transport, tissue sources.

Personal note: this collab started from an email after I read a conference abstract from @iampeteroni+ @RourkeLab — delighted it led to a review

[Barry Scott @BazFScott]

@WeiWei_Stanford @UWBiochem @uwmadisonipib Congratulations @WeiWei_Stanford! Wishing you all the best as you launch your lab at UW–Madison—excited to see the science to come!

[Barry Scott @BazFScott]

@lynchielydia @DavidFinlayTCD @tcdTBSI Very cool, @lynchielydia! It was a bit of a whirlwind, but I’m so glad we got it out there. I’m hopeful it will make a real contribution—especially highlighting how Lac-Phe increases after meals and why the body might use it as an appetite suppressor. 🧬📚

[Barry Scott @BazFScott]

@lynchielydia Thanks Lydia!

[Barry Scott @BazFScott]

@Fredtwee @DavidFinlayTCD @lynchielydia Huge thanks to @Fredtwee for your guidance over the past four years. Your suggestion to look into an internship at @Metabolon was absolutely spot on!

[Barry Scott @BazFScott]

Thrilled to share that I’ve passed my PhD Viva! 🎉

A huge thank you to @DavidFinlayTCD, my co-supervisor @lynchielydia and the brilliant teams in the Finlay Lab and Lynch Lab. Grateful for all the support along the way, especially from my family.

Excited for what comes next! 🚀

[Barry Scott @BazFScott]

@EmDay4 Thanks Emily! Hope all is going well with your new position!

[Barry Scott @BazFScott]

@jens_lund @longlabstanford findings on CNDP2 KO with metformin, and the fact that Lac-Phe levels increase after meals 🍽, suggest there's really something here. 🔍

[Barry Scott @BazFScott]

@jens_lund Yes, that data did give me pause 🤔, though there's a discernible trend. Could it be that Lac-Phe's appetite suppression is influenced by other parameters?

[Barry Scott @BazFScott]

@jens_lund @DavidFinlayTCD @StephenORahilly @lynchielydia Could different CNDP2 products have distinct regulation at the membrane transport level, and also exhibit varying degradation rates?

[Barry Scott @BazFScott]

@jens_lund @DavidFinlayTCD @StephenORahilly @lynchielydia Great point on CNDP2's role. It's worth considering if CNDP2 could also signal excess of substrates beyond lactate

[stephen o'rahilly (its pronounced O-RA-hill-EEE) @StephenORahilly]

https://t.co/cJ0YL1rnaV and https://t.co/AqbEYUOxya
Two interesting papers on metformin's action to elevate circulating Lac-Phe. Non-specific product of anaerobic metabolism or physiological mediator of appetite? The jury is still out I would say. I cant find any mention/

[Barry Scott @BazFScott]

@DavidFinlayTCD @StephenORahilly @lynchielydia Highlighting @VamsiMootha's work: 2 recent papers present Lac-Phe as biomarkers for mitochondrial disease (alongside GDF15) and sepsis, expanding our understanding
https://t.co/9jCFG0yFu9
https://t.co/H7SCUIDoW4

[Barry Scott @BazFScott]

@DavidFinlayTCD @StephenORahilly @lynchielydia I suspect N-lactoyl aa's offers the body a different signal compared to lactate, due to their slower degradation rate. This nuance could be key