Beckmann Lab

No longer updating this account. Find us @beckmannlab.🦋.social

[Antonio J. Pierik @AJPierik]

Read Rosales-Hernandez et al. https://t.co/hGCYjaO1nu and Zerbes/Colina-Tenorio et al. https://t.co/3tl0q05sy0 to find out about delivery of the Rieske protein after Bcs1 transport to Mar26 and MICOS for bc1 complex assembly.

[Beckmann Lab @BeckmannLab]

Our results finally explain the essential role of snR30 snoRNA! Check out the details in our preprint to find out more 👉👉👉 https://t.co/UJ8ib8Miw0
#ribosome #cryoEM #RNA

[Beckmann Lab @BeckmannLab]

First structure of a H/ACA snoRNP acting in ribosome synthesis. In a great collaboration with the Hurt lab, we provide a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇

[Nature Communications @NatureComms]

Authors including @jingdongcheng report cryo-EM structures revealing how antibiotic tigecycline can also target human mitoribosome.

https://t.co/HFoYItNpQl

[Beckmann Lab @BeckmannLab]

Also check out the paper by @zeqiraj and @YKulathu: https://t.co/xd2YYVi5G3

[Beckmann Lab @BeckmannLab]

Fresh out of the oven, our collaboration with the Kopito Lab - UFL1(E3) modifies, binds to, and dissociates the 60S subunit from the Sec61 translocon! #ribosome #cryoEM

[Beckmann Lab @BeckmannLab]

Check out the the full story here: https://t.co/SKy4DCfght

[Beckmann Lab @BeckmannLab]

@IsraelF96135088 Negroni?

[Beckmann Lab @BeckmannLab]

@petesoi1 @ERC_Research @CEITEC_Brno Congratulations Petr, all the best!

[Beckmann Lab @BeckmannLab]

For a more detailed look, check out the paper now👉 https://t.co/zaeCJYsPga

[Beckmann Lab @BeckmannLab]

🎉We are thrilled to share our exciting new collaboration with @inada_lab and @jingdongcheng on how Otu2 recognizes and deubiquitinates 40S ribosomes after translation. Here is a thread with the most interesting findings:👇 #ribosome #ubiquitin #cryoEM

[Beckmann Lab @BeckmannLab]

Otu2 can bind to 40S during cytoplasmic ribosome biogenesis and all stages between ribosome recycling and start-codon recognition, but becomes a highly specific enzyme for translational reset during recycling/(re)initiation by removing mono-ubiquitin present on eS7.

[Green Lab @GreenLabJHMI]

Turns out MutS2 just doesn’t cut it ✂️ despite it having an SMR domain! Our latest collaboration with the @BeckmannLab characterizing the role of MutS2 in splitting stalled ribosomes in B. subtilis.

https://t.co/OfAJSzBeOR

[Jingdong Cheng @jingdongcheng]

Let's rotate! Thanks to the great Hurt lab and @BeckmannLab, our story on the 60S ribosome biogenesis is finally out in EMBO reports. We find the 5S RNP in a new rotate conformation when stably incorporate into the nucleolar pre-60S. #cryoEM #ribosome
https://t.co/w6sIVUGKvw

[QMB Munich @MunichQbm]

Its online:🥳🎊🎉 Check out the @MathWorksAI user story🍻
https://t.co/Ikr9VP8TfG about our (@BeckmannLab, @hopfnerlab) DL based Cryo-EM image analysis tool (https://t.co/wgclFJYrhI). Thank you @MathWorks for the great support!👍👍

[Beckmann Lab @BeckmannLab]

Check the full story here 👉🏻👉🏻👉🏻https://t.co/EqyokLMKwa

[Beckmann Lab @BeckmannLab]

Keeping up the momentum, we're excited to share the final version of our story about RQT-driven ribosomal splitting 🎉 🎉 Shout out to @KaBe__01, @ThomasB08006066, @inada_lab and everyone involved! Read on to learn more👇🏻👇🏻👇🏻 #cryoEM #ribosome #RQT

[Beckmann Lab @BeckmannLab]

Pull the ripcord to clear the traffic jam: RQT splits collided #ribosomes by engaging the emerging mRNA. Check out our new story at #bioRxiv: https://t.co/JhCklVwKvW

[Beckmann Lab @BeckmannLab]

The Ski2-like helicase 1 subunit applies a pulling force on the mRNA which causes RQT to swivel between two conformations. This leads to the destabilization of the 40S subunit, resulting in subunit dissociation of the leading ribosome.