BeforeStageOne

The science and clinical implementation of multi-cancer early detection. Written by @MichaelLaPelusa. Find more:

[Michael LaPelusa, MD @MichaelLaPelusa]

Check out (below) our new page covering the potential ways to work up each of the possible cancer signal origins for a positive multi-cancer early detection (MCED) test. @BeforeStageOne

[Michael LaPelusa, MD @MichaelLaPelusa]

As of now, there are four multi-cancer early detection (MCED) tests worth comparing: Galleri (@GrailBio), Cancerguard (@AbbottNews), Detect (@carisls), and Shield MCD (@GuardantHealth). I put their cost, cancers covered, intended population, sensitivity and specificity, performance by stage, cancer signal origin accuracy, and where each test's evidence comes from side-by-side @BeforeStageOne! See below.

[Michael LaPelusa, MD @MichaelLaPelusa]

Thank you, @oncodaily, for featuring this post! Below are the results of a poll on the expected outcome. I'll be covering the committee's decision at @BeforeStageOne.

[BeforeStageOne @BeforeStageOne]

Post 12 - Journal Club: NHS-Galleri (GRAIL)
https://t.co/dGGY70kqRB

[BeforeStageOne @BeforeStageOne]

Post 11 - The Competitive Landscape
https://t.co/cqvUlTDXkH

[Michael LaPelusa, MD @MichaelLaPelusa]

On September 23, an @FDA advisory committee will review a Premarket Approval application from GRAIL (@GrailBio) for its Galleri multi-cancer early detection (MCED) test. It will be the first time an MCED test gets reviewed by such a committee. What do you expect?

[BeforeStageOne @BeforeStageOne]

Post 10 - Regulation and Reimbursement
https://t.co/utbbFUgZgE

[BeforeStageOne @BeforeStageOne]

Post 9 - The Case Against the Blood Test
https://t.co/akxA0E49SP

[BeforeStageOne @BeforeStageOne]

Post 8 - Journal Club: Shield MCD (Guardant)
https://t.co/xrxwcTipBe

[BeforeStageOne @BeforeStageOne]

Post 7 - Journal Club: DETECT-A and Cancerguard (Exact Sciences)
https://t.co/bxcBuCWyBp

[BeforeStageOne @BeforeStageOne]

Post 6 - Journal Club: PATHFINDER 2 (GRAIL)
https://t.co/gA8ENFSl74

[BeforeStageOne @BeforeStageOne]

Post 5 - Journal Club: PATHFINDER (GRAIL)
https://t.co/SnJeOdrtzN

[BeforeStageOne @BeforeStageOne]

Post 4 - Journal Club: CCGA (GRAIL)
https://t.co/wtMSGMboO0

[BeforeStageOne @BeforeStageOne]

Post 3 - Statistical Terms
https://t.co/2ofnzhvWmh

[Michael LaPelusa, MD @MichaelLaPelusa]

Over the past month, I've been writing down my thoughts about multi-cancer early detection tests and decided to turn them into a series of 12 posts. Follow @BeforeStageOne and/or check out https://t.co/UuYz7Z5TVq for more.

[BeforeStageOne @BeforeStageOne]

Post 2 - How MCED Testing Works
https://t.co/y22QIv1K1s

[BeforeStageOne @BeforeStageOne]

Post 1 - Why I'm Doing This
https://t.co/gWMx1eyQ4d