Bement Lab

Transient contractile arrays. Part of the Center for Quantitative Cell Imaging (@UWCQCI) at UW-Madison. Tweets mostly by @ZacSwider and @AniMichaud1.

[Bement Lab @BementLab]

Join @AniMichaud1 on a tour of the Bement lab @UWMadison and see what we're all about! #CellBiology

https://t.co/6a1EnNAdJY

[Zac Swider @ZacSwider]

Any #microscopy friends have any suggestions for a water stage cooler/pump? I'm specifically interested in something to slowly flow water through a light sheet imaging chamber so it will need a very slow and consistent flow rate. Maybe @ZakSwartz ?

[Bement Lab @BementLab]

@sanewman1 Yes exactly! But in a biological system 😎

[Bement Lab @BementLab]

@CAS_mitolab

[Bement Lab @BementLab]

@joachimgoedhart That’s usually what we look like in the microscope room 😵‍💫

[Bement Lab @BementLab]

@jboerckel @AniMichaud1 @ZacSwider 👀

[Bement Lab @BementLab]

How does RGA get recruited to cortical waves and what exactly is the nature of its relationship with F-actin? We aren't sure, but we plan to use immature frog oocytes and modeling to address these questions!

[Bement Lab @BementLab]

Our latest pre-print is up on @bioRxiv! Here, @AniMichaud1 et al. identified Ect2 and RGA-3/4 as core components of cytokinetic cortical excitability. We also show that immature Xenopus oocytes are a powerful model for characterizing excitability. A 🧵...
https://t.co/NE8lIxLov1

[Bement Lab @BementLab]

Modeling and experiments showed that Ect2 and RGA-3/4 are major drivers of this circuit, and just altering the relative levels of these two players produced a variety of cortical behaviors in an otherwise quiescent oocyte cortex!