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Ben Hollensbe
@BenHollensbe
Joined November 2022
67 Following
14 Followers
168 Posts
$NWBO
Amanda and Braelyn flew back to London Wednesday as Braelyn continues to battle glioblastoma.
Her family is encouraged by a promising, non-toxic treatment two top U.S. cancer centers never mentioned - a treatment developed by an American company.
Friday’s appointment is quick. The trip is not: two transatlantic flights, a hotel, and everything that comes with it.
“We’re flying 4,000 miles for a U.S.-developed cancer treatment. Braelyn is 19. She just started college. Yesterday she was in the Charlotte airport taking an online class before an overnight flight.
She should be home with friends getting stronger — not crossing the Atlantic for a treatment that should be available here.
When she was diagnosed, no one even told us about DCVax. I found it myself.
We’re grateful she can get it in the UK and we’ll keep getting on these planes. Patients shouldn’t have to. They need a fair, efficient regulatory path — and they need to know these options exist.
Friday: DCVax #4 at King’s College. I’ll keep fighting so another family doesn’t have to fly 4,000 miles to do what we’re doing today.”
- @HollensbeAmanda
Video #14
🧵of Videos 👇
@HollensbeBrae @BenHollensbe @andrewcaravello @gr197667 @SpimacoAddwaeih @MHRAgovuk
College doesn’t stop for cancer treatment.
We got to the airport VERY early today so Braelyn could attend her synchronous online class without having to worry about rushing through class, security, and boarding.
So here we are—laptop open, class in session, passports ready. ✈️📚
We take off for London at 6 PM and land at 7 AM tomorrow. Then it’s off to King’s College Hospital Friday for DCVax #4! 💉🇬🇧
I’m so proud of this girl for continuing to move forward with her life while simultaneously fighting for it.
London, here we come!
Go get ’em, DCs!! 🧬💪❤️
#DCvaxForBraelyn
Charlotte's Brain Tumour Journey
Diagnosis to Death: 951 days
Age 19
18.2.97 - 24.2.16
29.8.13
We left home at 10.45 am, as we had to be at The Marsden for 12.00 pm for Charlotte to have her Portacath fitted. This is a small medical device that provides long-term access to a major vein for her chemotherapy, replacing the need to have a cannula inserted each time.
Charlotte was understandably apprehensive. The port was going to be inserted on the right-hand side of her chest. We had been told that it was a relatively quick procedure. The surgeon would make an incision, create a small pocket beneath the skin, insert the port and then stitch everything back together. They had also implied that it wouldn't be particularly painful.
They took Charlotte into the theatre, and I stayed with her for as long as I could before they asked me to leave.
When she began to stir after the procedure, she was crying in pain.
"Get this out of me."
She told me that the pain was unbearable.
They gave her a considerable amount of pain relief, but sadly the pain was to continue for another ten days or so.
While we were at The Marsden, Charlotte was examined and we were reassured that, at this point, she was neurologically well.
For the moment, that was something to hold on to.
1.9.13
Today is Miles’ birthday. Later this month, he will be heading off to university, which should be such an exciting and happy time for all of us.
We are doing our best to celebrate with him today, but, inevitably, everything has been overshadowed by the situation we are facing with Charlotte.
Today, Charlotte has been suffering with severe indigestion and a slight headache, which is worrying me. I find myself constantly wondering whether the pressure in her head could be building up again. It is incredibly difficult not to worry when every new symptom makes you question what might be happening.
Her Portacath is really getting her down today too. She is resting a lot, and at the moment, all I can do is give her pain relief, keep her comfortable and hope that things improve.
It is so hard watching your child go through this, particularly on a day that should be filled with celebration. We are trying to make the most of Miles’s birthday and hold on to the happy moments, while hoping and praying that Charlotte has a better day tomorrow.
2.9.13
Back to The Marsden today for Charlotte to have her Vincristine administered.
Later in the evening Charlotte has been saying that her left arm feels very sore and heavy. I’ve given her pain relief, but unfortunately it doesn’t seem to be making any difference.
We have to go to the local hospital tomorrow, so I will make sure they check it then.
Another day, another hospital appointment.
It was becoming increasingly clear that our lives were now being governed by cancer. Every day seemed to revolve around hospitals, treatments, medications and the next appointment. There was very little space left for anything else.
If you would like to support, self-funding brain tumour charity where 100% of your donation goes directly to research in Charlotte's Lab at King's College Hospital, London, we would be incredibly grateful.
No salaries.
No overheads.
No advertising.
No merchandise.
We even cover the PayPal and PO Box fees personally so nothing is taken from the charity account.
https://t.co/mrMKrVYPrx
Please RT with thanks
Arsenal have been trying to sign an explosive winger since Mudryk - it's 2026, we are Premier League Champions, armed with enough money to have Vini Jnr pay attention, and our wings are slower now than they were this time last year (so far).
What I find so sad is that, had my daughter had a massive celebrity connection, her story would probably have been known worldwide
But Charlotte wasn't a celebrity.
She was simply a normal young girl with hopes, dreams and a future ahead of her.
She was diagnosed with an aggressive brain tumour at just sixteen years old and died aged only nineteen.
Her life mattered.
Her story matters.
There are thousands of Charlotte's - ordinary people and families whose lives are turned upside down by this cruel disease.
That is why I continue to tell her story.
Not because she was famous.
But because she was Charlotte.
If you would like to support, self-funding brain tumour charity where 100% of your donation goes directly to research in Charlotte's Lab at King's College Hospital, London, we would be incredibly grateful.
No salaries.
No overheads.
No advertising.
No merchandise.
We are incredibly proud that our charity is entirely self-funding.
We even personally cover the PayPal fees and PO Box costs, ensuring that nothing is taken from the charity account.
Every penny donated goes where it is intended to support vital brain tumour research.
Charlotte was brave, kind and wise beyond her years. She shared her journey openly on her YouTube channel.
Her final video was filmed on 4 February 2016, the day before she went into a coma.
Since then, Charlotte's channel has been watched more than 28 million times around the world.
Through her videos, Charlotte continues to tell her story in her own words.
And through that, her legacy lives on.
18.2.97 - 24.2.16
Diagnosis to Death: 951 days
https://t.co/qGIjBOl3aq
Please RT with thanks
Today, Miles and I went to King's College Hospital to present a cheque for an incredible £400,000 to Charlotte's Lab. It was a very special and emotional moment for us. Every penny has been raised in Charlotte's memory and will support the vital brain tumour research being carried out in the lab. We decided to have a reusable cheque made, because we are already looking ahead to the next milestone: £500,000. Thank you to every single person who has donated, fundraised, supported and believed in what we are trying to achieve.
Charlotte’s BAG has funded research into cutting-edge diagnostic techniques, most recently with Oxford Nanopore Technology. It uses AI-based technology to process vast quantities of data and match the DNA of a tumour with hundreds of thousands of other tumours stored on an international database. Incredibly, this has reduced diagnostic times from three months - to just 24 hours. The impact of this is immeasurable. While Glioblastoma is difficult to treat, a much faster diagnosis removes uncertainty, and enables tailoring of treatment. Patients can focus their precious time on being with loved ones and on activities they enjoy. Professor Keyoumars Ashkan MBE, Professor of Neurosurgery and Consultant Neurosurgeon, at King’s College Hospital, said: "The work that Alex and Miles have done is truly remarkable; an outstanding contribution to the care of glioma patients and a true sentiment to Charlotte's memory.
Please RT with thanks
If you would like to support a small, self-funding brain tumour charity where 100% of your donation goes directly to research in Charlotte's Lab at King's College Hospital, London, we would be incredibly grateful.
We are now just £91,967.94 short of reaching our next milestone of £500,000 raised for brain tumour research.
No salaries.
No overheads.
No advertising.
No merchandise.
https://t.co/qGIjBOl3aq
I was Charlotte.
I was born in Brighton on 18 February 1997.
I loved handbags and fashion. I was looking forward to having a career. I was looking forward to getting married and having children. I was looking forward to growing old and enjoying a long and happy retirement.
But none of that ever happened.
That's why I write about myself in the past.
I left this Earth in 2016, when I was just 19
My mother is now raising awareness of brain tumours
Every day, she shares my journey and tells my story, so that people can understand what this cruel disease can do.
She also set up a charity in my name, helping to fund vital brain tumour research.
I wasn't a celebrity.
I was simply Charlotte.
A daughter, sister, granddaughter, niece and a friend.
A young woman who had hopes, dreams and a future that should have been mine.
Please RT & help my mother & brother keep my story alive.
https://t.co/qGIjBOl3aq
If you would like to support a small, self-funding charity where 100% of your donation goes directly to brain tumour research, please consider popping a pound into Charlotte's Bag.
Charlotte's Brain Tumour Journey
Diagnosis to Death: 951 days
Age 19
18.2.97 - 24.2.16
23 August 2013
Well, I thought yesterday was bad, but today was even more upsetting.
Charlotte had just had a bath and tried to wash her hair while fighting back the tears. The long, thick hair she used to lovingly condition for ten minutes at a time was no longer there. It was so much shorter and had no style to it.
I was cooking in the kitchen when Charlotte came in. She took a carrier bag out of the cupboard and some scissors from the drawer.
She stood in front of me and announced that she needed to get rid of it all because she was going to lose it anyway.
She asked me to hold the bag open
She took a large bundle of hair and pulled it away from her scalp. Then came the sound of the scissors cutting through her hair. It wasn't easy, as she had such a large handful of it. She cut randomly, not caring what it looked like.
She then shaved the rest of it off using a number one all over.
When all of Charlotte's hair had gone, she actually felt better. She said it was much better than waking up in the morning and finding it all over her pillow.
At least this had been her decision.
Later that day, we still had blood tests. A nurse would come from the local hospital.
Blood tests were going to become another part of our lives.
It seemed that cancer was beginning to govern everything.
https://t.co/mrMKrVYPrx
Charlotte's BAG has funded vital research into speeding up the results of biopsies for patients and clinicians.
Charlotte’s BAG has raised £407,292.52
directly funding research at Charlotte’s Lab, King’s College Hospital, London
We are now £92,707.48 short of raising £500k
If you would like to support a small, self-funding brain tumour charity where 100% of your donation goes directly to research in Charlotte's Lab at King's College Hospital, London, we would be incredibly grateful.
No salaries, overheads, advertising or merchandise.
Every RT helps us reach more people and continue supporting vital brain tumour research in Charlotte's Lab.
Thank you for your support.
RT @alexeades1: Charlotte's Brain Tumour Journey
Diagnosis to Death: 951 days
Age: 19
18.2.97 - 24.2.16
13 years ago today 22 August 201…
First week of college classes coming to an end!!
$NWBO 🧩 1. What the MHRA Actually Says
In official guidance, legal reforms (SI 2025 No. 87), and strategic briefings especially the July 23, 2023 Point-of-Care Manufacturing Consultation, the MHRA repeatedly highlights its top priority:
“Personally Individualised Cancer Vaccines” (PICVs)
They define these as:
“Therapies manufactured at the point of care, tailored from the patient’s own cells or tumour material, intended to activate an immune response against unique tumour neoantigens.”
That definition does not describe mRNA. It describes a personalized, cell-based immunotherapy, built from the patient’s biology.
🧬 2. PICV is Not mRNA
mRNA vaccines (BioNTech, Moderna, etc.):
‣ Are made using synthetic RNA based on shared or predicted antigens
‣ Are manufactured centrally in large batches
‣ Do not use patient-derived tissue or cells
‣ Are not produced at the bedside
‣ Are not personalized in the biological sense, only algorithmically
By contrast, PICVs as defined by the MHRA:
‣ Use autologous tumor or immune material
‣ Are custom-made for each individual
‣ Are manufactured at or near the point of care
‣ Function as therapeutic vaccines based on actual tumor neoantigens, not predictions
This is the regulatory domain of autologous dendritic cell vaccines, not mRNA.
📜 3. MHRA’s Own Words Make It Unmistakable
MHRA language removes all ambiguity:
From the 2023 consultation:
“Personalised cancer vaccines represent a new therapeutic class, frequently involving cellular products or autologous tissue processing”
From SI 2025/87:
“Manufacture and supply of a medicine may take place at or near the point of care… including individualised therapies such as autologous dendritic cell products”
From internal guidance and strategic briefings:
“First priority is establishing regulatory clarity and pathways for personally individualised immunotherapies including dendritic cell-based vaccines and other autologous formulations”
No part of that applies to mRNA.
Every part of it applies to DCVax.
🧠 4. Why This Regulatory Overhaul Proves the Point
If PICVs were mRNA, the MHRA wouldn’t have needed new laws.
mRNA already fits into:
• Established EMA and FDA biologic approval processes
• Centralized manufacturing norms
• Existing GMP release systems
• Traditional batch consistency rules
But for PICVs, the MHRA had to build:
• A dynamic licensing system
• Real-time, patient-level batch release models
• On-site regulatory accountability for POC manufacturing
• A structure that supports decentralization and personal customization
That infrastructure is overkill for mRNA. But it’s essential for DCVax.
🔎 5. What Else Fits? Actually, Nothing Fully Does
You might find a few therapies that seem adjacent to the MHRA’s PICV definition. But none meet the full scientific, operational, and regulatory criteria.
Sipuleucel‑T (Provenge)Autologous and FDA-approved, but limited to prostate cancer. Uses predefined antigens, not whole tumor lysate. Never scaled. No automation. No MHRA filing. Commercial failure.
ERC1671 (Gliovac / Sitoiganap)Combines autologous and allogeneic tumor cells, but lacks a dendritic cell component and point-of-care automation. Still in small academic trials. No UK infrastructure or regulatory momentum.
TG4050 (Transgene)Uses viral vectors to deliver predicted neoantigens. Not autologous. Centralized production. Doesn’t match bedside model or cellular design.
Eftilagimod Alpha (IMP321)A dendritic cell stimulator, not a vaccine. Used as an adjuvant. Not individualized. Not autologous. Not a stand-alone therapeutic.
Now contrast that with DCVax-L:
• Uses the patient’s own dendritic cells
• Loaded with that patient’s full tumor lysate, ensuring broad neoantigen coverage
• Produced using closed-system automation (Flaskworks) compatible with MHRA POC licensing
• Designed for real-time, patient-specific manufacture and delivery
• Under active MHRA regulatory review, with established Phase III survival data
• Filed for formal approval under the exact system MHRA just built
Only DCVax fits every single criterion.
Everything else either lacks the biology, the logistics, the regulatory positioning, or all three.
✅ 6. Conclusion
DCVax is not simply compatible with the MHRA’s PICV framework.
It is the reason that framework had to be built.
mRNA doesn’t need a new licensing regime.
mRNA doesn’t use autologous cells.
mRNA doesn’t require point-of-care manufacture.
mRNA doesn’t function as a truly personalized immune vaccine based on real tumor biology.
DCVax does all of that, and it’s already sitting inside the regulatory pathway MHRA just carved out.
There is no confusion here.
MHRA’s PICV framework was not made for a platform that already had a pathway.
It was made for a platform that never did, until now.
And that platform is DCVax.
@ThomasOwenMcCa1 @kshaughnessy2 @parkerici @kristendahlgren @DanaFarber @DanaFarberNews @USATODAY @TODAYshow @BBCWorld @BBCBreaking @GMA @michaelstrahan @nypost @NorthwestBio @LisainNJUSA @glioblastomaorg @NoBrainCancer @nytimes @60Minutes @WSJ @business @aljedai @SpimacoAddwaeih She had a medullablastoma.
Meanwhile you guys are SILENT on a promising glioblastoma treatment/cure called DCVax. $NWBO. Survivors over 10 and 20 years.
Do your homework..
“…What the Phase III data show
In the completed Phase III trial of DCVax-L in newly diagnosed and recurrent glioblastoma, Northwest Biotherapeutics has reported:
•Improved median overall survival compared with control patients receiving standard care alone.
•A higher percentage of patients alive at longer time points (multiple years), forming a stronger “long tail” of extended survival….”
@ucla @NorthwestBio @HollensbeAmanda @ThomasOwenMcCa1 @LisainNJUSA @andrewcaravello
$NWBO
Amanda Hollensbe is fighting to save her daughter Braelyn’s life.
She wrote this letter to the UK Prime Minister and the Chief Executive of the MHRA
Braelyn spent much of the summer in London so she could get her first three doses of DCVax - a non-toxic glioblastoma vaccine made by an American company.
A promising treatment U.S. regulators still won’t approve.
The data is there.
10-and 20-year + glioblastoma survivors exist.
The UK gave her a chance.
Regulators everywhere are still moving like they have all the time in the world.
Glioblastoma patients don’t.
Video #11 (other videos are in this thread. Please repost)
@HollensbeAmanda @gr197667 @andrewcaravello @MHRAgovuk @RobertKennedyJr
🔥🔥$NWBO Three formidable women. Three distinct strengths. One mission: drive DCVax-L across the finish line.
Each holds a critical piece of the puzzle.
Linda Powers – The Force
CEO and Chairman. She has steered NWBO through every storm for over a decade.
Strategic vision. Relentless execution. Capital navigation. Regulatory grind.
The leader who refuses to quit and keeps the company standing and fighting.
Dr. Linda Liau – The Science
World-class neurosurgeon. Pioneer of the dendritic cell vaccine for brain cancer.
Principal Investigator of the Phase 3 trial. Scientific Advisory Board.
Deep clinical credibility. Decades of hands-on innovation.
The one who proved what DCVax-L can do in patients.
Annalisa Jenkins – The Accelerator
Strategic Adviser. 25+ years of global biopharma leadership.
Former pharma R&D executive. Biotech CEO. FDA Science Board. OBE.
She brings high-level regulatory insight, commercialization expertise, and platform expansion strategy.
The piece that helps convert science and perseverance into broader success.
Together they cover the full spectrum:
Leadership. Science. Strategy.
One builds the company.
One validates the medicine.
One accelerates the path forward.
These are the women pushing DCVax-L toward approval and beyond.
----------------
Let's also point out:
Amanda and Braelyn Hollensbe: literally LIVING THE BATTLE to show that DCVax-L can bring hope, survival, and life to GBM sufferers.
Laura Posner: pit bull lead attorney for Cohen Milstein, fighting to expose the short & distort criminals that stand between a promising cure and the patients who need it.
$NWBO
Ismael Saibari ran over to Jamal Musiala as soon as he saw Musiala was about to faint. Musiala partially fainted due to the heat and was cleared by Bayern's medical team after.
The definition of a true teammate in Saibari ❤️
We are just £158 away from raising £5,000
Our 200-mile (220 in the end) walk over 12 days is now complete, but we're still hoping to reach this amazing fundraising milestone.
Is there anyone out there who could help us get over the line?
Every donation, no matter how small, will make a difference and will go directly towards Charlotte's Lab and vital brain tumour research.
If you can donate or RT this post, Miles and I would be incredibly grateful.
Just £158 to go!
Thank you, as always, for supporting Charlotte's legacy.
https://t.co/wCoNQTmu2X
https://t.co/mrMKrVYPrx
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