@gamechangercap @Biotech2k1 Irak4 and hpk1. Both seem to be gilead targets. Arvinas also has an hpk1 protac in research and an irak4 protac is being developed by kymr/sanofi.
@ohadhammer@TheATGCSeeker@Mykalt45 I think the MTA cooperative prmt5 inhibitors can open the therapeutic window for MTAP. Amgen just started enrolling patients for theirs.
$BPMC looking to start a position. Really excited for early look at BLU-701 and BLU-945. I like the combination idea to drive deep and and durable responses, potentially covering multiple acquired resistance mutations. Along with the ability to control CNS metastasis.
@BioWino@Sanctuary_Bio@retailbiotech Crazy how you have a company like $lyel that has 900m in cash with a GSK partnership and a pre clinical ror1 car targeting TNBC and NSCLC🤔. 2B MC… 50% off ATH… not a much talked about name. Interesting story that’s for sure.
@JRMKE3@brendan_49 I remember when they announced first patient dosed it was r/r ALL at 90M cells. Is there a specific call or report they discuss that dosing reg you speak of ?