Healthy people show a brief FGF21 drop after stress, while those with mitochondrial disease show a delayed rise. FGF21 also reflects social and emotional factors, linking stress and metabolic health.
https://t.co/yhnxrdYZnN
Fasting triggers the body to shift from using glucose to burning fat and producing ketones, coordinated by hormones and liver signals like FGF21. Mice without liver-produced FGF21 still showed normal fasting metabolism, but they lost the usual increase in protein appetite
In C. elegans, the RNA that maintains chromosome ends doesn't have its own gene but is hidden inside another gene and "hitchhikes" there. This discovery may be common in animals and could inform future regenerative medicine research.
https://t.co/6ol0mrl7nc
PAX3 and PAX7 guide the development of different neural cell types in the embryonic spinal cord. This activation occurs only in cells exposed to BMP signals.
https://t.co/9s45pnLRH8
Scientists at The University of Texas at Austin have developed a revolutionary gene-editing method using bacterial retrons that can correct multiple disease-causing mutations at once.
https://t.co/9GVQ4CIg9u
"A neurologist at the University of Cambridge, used data from the massive UK Biobank resource and found a link between reduced glymphatic function and increased risk of dementia.
https://t.co/pIqvO3RGQ7
In the poll kids generally believed 49 years old was -- old! and, "One in five children believe adults stop having fun and exercising at 30-years-old and nearly half of those polled said they believed their parents were old."
https://t.co/Qdkj9sr2kd
“ Whether we damaged the mitochondria or the telomeres we got dysfunctional T cells. There is crosstalk between the engine of the cell and the brains of the cell, the mitochondria, and the nucleus. something we didn’t appreciate in immune system.”
https://t.co/CNWbZSMvFt
This study is among the first to show that the first weeks of life, when the immune system is naturally more tolerant, may be the optimal window for delivering gene therapies that would otherwise be rejected at older ages.
https://t.co/jRE706H3nq
Genetic risk variants don’t always cause disease, and outcomes can vary among carriers. Poeschla et al. suggest this is partly due to common variants—such as those affecting telomere length—
https://t.co/UtwqxvFeJT
Telomere fragility is linked to telomere length and telomerase activity. Lab tests confirmed that short telomeres were more fragile, especially in clones with lower telomerase activity.https://t.co/WTWcZ1OXtJ
T-cell lymphopenia is a key feature of immunodeficiency in telomere biology disorders and is linked to higher risks of serious infections, cancer, and reduced survival.
https://t.co/3bRFRPYZ7m
Those who developed kidney problems (AKI) had lower levels of Klotho. People with higher Klotho levels had better chances of recovery. Klotho was also a better warning sign of kidney issues than the usual test (creatinine).
https://t.co/bkkIKVibSh
Double the risk? Variants in the homeostatic iron regulator (HFE) gene are prevalent among individuals of European ancestry and have been linked to an increased risk of dementia.
https://t.co/0DUybDsAMw