#OPENACCESS: Endogenous and exogenous actin modifications alter F-actin network architecture and mechanics by charge redistribution. Peter Nietmann, Susanne Stenz, Kevin Kaub, Andrejus Suchenko, Mohan K. Balasubramanian, and Andreas Janshoff. https://t.co/8cyrelNWkX
Special issue call for papers: Genome Organization: Integrating Mathematics, Physics, and Computation for Advances in Biology and Medicine. https://t.co/XDo99yQgWf
#OPENACCESS: A new framework, which also accounts for condensate motion, to correctly determine if a molecule is inside the condensate or in the surroundings. Test your system now! https://t.co/gIKzvT9oFg
Study combines agent-based simulations with coarse-grained thermodynamic analysis to reveal how molecular motor activity drives active asters to reorganize into bundle-like structures, illustrating how mesoscopic architecture shapes mechanical response. https://t.co/Mb9ztoPrvG
#OPENACCESS: Hypoxia-responsive HIF-1α-dependent RhoA signaling promotes motility and aerotaxis in polyaneuploid PC3 cancer cells with increased nuclear rounding. Noreen Hosny, Shengkai Li et al. https://t.co/AbdRW1zCE0
Beta cells don’t solo—they play as an orchestra. Barać et al. explore how cellular oscillations synchronize across scales to coordinate hormone secretion. From tiny cellular rhythms to a whole-body signal: biology knows how to keep the beat. https://t.co/4QDWvAl6cO
#OPENACCESS: Whole-cell spatiotemporal model and multimodal data illuminate the multiscale light responses in a photosynthetic bacterium. Connah G.M. Johnson, Aaron Chan et al. https://t.co/Eh11rqiZCf
Flexible proteins are molecular yoga masters—twisting through ensembles of conformations rather than holding one pose. Rodriguez et al. ask the big question: how well can our models predict this molecular flexibility?
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How much force does it take to pull an integrin apart? New study reveals a high mechanical threshold required to separate α5β1 integrin transmembrane domains, uncovering a “ratchet-like” role underlying inside-out signaling. https://t.co/hVxYSJ8bsw
#OPENACCESS: Snapshots of internal protein crystal architecture at the nanoscale. Shervin S. Nia, Ambarneil Saha, Jung Cho, Z. Hong Zhou, Peter Ercius, and Matthew Mecklenburg. https://t.co/vb2ib1fegg
#OPENACCESS: An alteration in the binding-unbinding interaction mechanism in a protein-specific condensate system impacts the exchange dynamics, aging, and size distribution of condensates—revealed by simulations. https://t.co/tcKBK00nQD
#OPENACCESS: An energy-based mathematical model of actin-driven protrusions in eukaryotic chemotaxis. Samuel W.S. Johnson, Maddy Parsons, Ruth E. Baker, and Philip K. Maini. https://t.co/MXt8HemtLD
Tumor cells have a memory—and hypoxia leaves receipts. Sadhu et al. show that how long cells experience low oxygen can shape their future invasive behavior. The past may literally steer the next move. https://t.co/j1tW6RdkLT
In the New and Notable "Lamin A-regulated chromatin organization regulates transcription factor binding," Yuxuan Huang and Alişya A. Anlaş highlight the paper "Lamin A depletion and RSG influence PPARγ DNA binding and chromatin organization in murine..." https://t.co/1sYACFWGzj