Biosplice Therapeutics

BioSplice Therapeutics | Phase 3 biotech company developing lorecivivint (SM04690), an investigational intra-articular therapy for knee osteoarthritis.

[Biosplice Therapeutics @biosplice]

More than 25 million Americans live with knee OA.

If you’re one of them, you deserve to be heard.

Make your voice heard. Tell Congress why OA needs better options.

Click here: https://t.co/15wZWQnnhG

#SickofkneeOA

[Biosplice Therapeutics @biosplice]

Tear your ACL and meniscus young, and your projected lifetime risk of needing a knee replacement nearly quadruples — from 6% to 22%.

A young athlete's injury today sets the pipeline for joint replacement decades later.

#KneeOA #Osteoarthritis #Biosplice #JointHealth #SportsMedicine

[Biosplice Therapeutics @biosplice]

More than 1 in 10 people with knee OA need help with basic personal care — dressing, bathing, getting around.

This isn't just about pain. It's about independence. About the daily tasks that become obstacles when a joint stops working.

#KneeOA #Osteoarthritis #Biosplice #JointHealth #DiseaseModification

[Biosplice Therapeutics @biosplice]

642 million people by 2050.

Knee OA is on track to affect 642 million people worldwide by 2050 — a projected 75% increase driven by aging populations and rising obesity.

Without a disease-modifying treatment, the world is on track for an epidemic we can't treat our way out of.

#KneeOA #Osteoarthritis #Biosplice #GlobalHealth #DiseaseModification

[Biosplice Therapeutics @biosplice]

An estimated 15 million US adults 25+ live with painful knee arthritis — more than the populations of NYC and LA combined.

This isn't a niche condition. It's an epidemic hiding in plain sight.

Source: Deshpande 2016. Estimated — OAPol model projection.

#KneeOA #Osteoarthritis #Biosplice #JointHealth

[Biosplice Therapeutics @biosplice]

OSTEOARTHRITIS isn't just wear and tear — it's a disease of the joint's structure.

Nearly 1 in 2 US adults age 45+ will develop painful knee arthritis in their lifetime (44.7% by age 85). For most of us, it's not a matter of if — it's when.

That's why symptom relief and disease modification aren't the same problem.

#KneeOA #Osteoarthritis #Biosplice #JointHealth #DiseaseModification

[Biosplice Therapeutics @biosplice]

@Raider_Dave13 ��� Fair. We walked right into that one.

[Biosplice Therapeutics @biosplice]

What’s the worst thing about knee OA?

[Biosplice Therapeutics @biosplice]

By 2030, the US is projected to perform over 1 million knee replacements a year. Demand keeps climbing — the need for earlier options is urgent. #KneeOA

[Biosplice Therapeutics @biosplice]

There's still no FDA-approved drug that stops or slows knee OA. Know the facts — and follow the fight for better knee OA care. #KneeOA #PatientAdvocacy

[Biosplice Therapeutics @biosplice]

Osteoarthritis cases have grown 132% in 30 years — from 256 million (1990) to 595 million (2020). The biggest driver isn't worse disease, it's an aging world. #KneeOA

[Biosplice Therapeutics @biosplice]

Across all Americans with knee OA, the inactivity the disease causes adds up to more than 7.5 million years of healthy life lost — collectively. The toll is enormous. #KneeOA

[Biosplice Therapeutics @biosplice]

A young athlete tears their ACL today. In 10–15 years, many face arthritis. In 20–30 years, many face a knee replacement. The surgery pipeline is set decades in advance. #KneeOA

[Biosplice Therapeutics @biosplice]

Knee OA isn't just an older person's disease. Over 21,000 active-duty US service members — young and fit by definition — were diagnosed with it in a single decade (2005–2014), and the rate kept climbing. #KneeOA

[Biosplice Therapeutics @biosplice]

Myth: strong opioids are the answer for knee OA pain. Reality: they're not significantly more effective than over-the-counter options — and carry far higher risks. #KneeOA

[Biosplice Therapeutics @biosplice]

Without better treatments, the world is on track for 642 million people with knee OA by 2050 — a 75% jump. The need is only growing. #KneeOA

[Biosplice Therapeutics @biosplice]

The typical age to be diagnosed with knee arthritis is estimated at 55 — squarely in the middle of your working life, not retirement. Knee OA isn't just for seniors. #KneeOA

[Biosplice Therapeutics @biosplice]

Myth: over-the-counter painkillers are harmless. Reality: 6 of 7 common painkillers studied for knee OA were linked to a 2–4× higher risk of heart attack, stroke, or CV death vs placebo. #KneeOA

[Biosplice Therapeutics @biosplice]

Knee replacement is major surgery with real risk: in a study of more than 367,000 US patients, about 1 in 90 developed a blood clot within 30 days. #KneeOA

[Biosplice Therapeutics @biosplice]

Tear your ACL young and as high as 87% go on to develop knee arthritis — and ACL surgery hasn't been shown to prevent it. Know your risk. #KneeOA

[Biosplice Therapeutics @biosplice]

Tomorrow kicks off the start of the DYRK conference. @Biosplice is excited to be presenting preclinical data for our #oncology and #neurology programs
https://t.co/tQ0Cxi6GQE