Steve Bosinger

Associate Professor at Emory University. Immunologist; Systems Biologist; Using genomics to study viral infections.

[HIPC @hipcProject]

Deep analysis of infant #immune responses to #SARSCoV2 (omicron) #proteomics #multiomics
From team including our collaborators: @SetteLab @Alba_Grifoni @YupengFeng @BosingerLab @purveshkhatri Bali Pulendran, and others.
@CellCellPress
https://t.co/c0NQqTxpSN

[Steve Bosinger @BosingerLab]

Join us for a new course offering this October. Registration is limited so be sure to sign up soon.

[Emory CFAR @EmoryCFAR]

Are you a faculty member, postdoctoral fellow, or graduate student actively engaged in research & looking to master single-cell RNA-Seq data analysis? Attend a new #EmoryCFAR Systems Immunology Core-hosted 8-week course detailed below. Apply here by 9/25: https://t.co/3EtNfDj9di

[Steve Bosinger @BosingerLab]

@MucosalGroup Thank you JoAnn!

[Steve Bosinger @BosingerLab]

Our new work with @PaiardiniLab and @elise_viox by @amitupadhyay85 featured by @SciImmunology

[Science Immunology @SciImmunology]

New primate research by @elise_viox and colleagues from @BosingerLab and @PaiardiniLab corroborates the theory that too little IFN-I exacerbates viral infection, while too much IFN-I leads to harmful immune hyperactivation. https://t.co/O4dH2AKvkR

[Science Immunology @SciImmunology]

New primate research by @elise_viox and colleagues from @BosingerLab and @PaiardiniLab corroborates the theory that too little IFN-I exacerbates viral infection, while too much IFN-I leads to harmful immune hyperactivation. https://t.co/O4dH2AKvkR

[Science Immunology @SciImmunology]

A new study in animals evaluates how the presence of anti-viral interferon-I (IFN-I) and related signaling affects #SARSCoV2 outcomes. @elise_viox @BosingerLab @PaiardiniLab

Learn more: https://t.co/QMRaGCQaGh

[Steve Bosinger @BosingerLab]

10/ We would like to thank all of our wonderful collaborators and the funding sources that made this study possible.

[Steve Bosinger @BosingerLab]

1/ Absolutely thrilled to announce the publication of our research on modulation of type I interferon in rhesus macaques! Our work was accomplished through close collaboration with the @PaiardiniLab and has now been featured in @SciImmunology. https://t.co/0uwTOEtZIR

[Steve Bosinger @BosingerLab]

9/ We would like to dedicate this study in loving memory of our friend & colleague Timothy Hoang. He made crucial contributions to the fields of HIV cure & SARS-CoV-2 research during his short but impactful career & is remembered for his drive, intelligence, and love of science.

[Steve Bosinger @BosingerLab]

Based on these results, we conclude that although IFN-I is beneficial in controlling SARS-CoV2 replication, excessive uncontrolled inflammation driven by IFN-I-signaling plays an important role in SARS-CoV2 pathogenesis.

[Steve Bosinger @BosingerLab]

scRNA-Seq showed that IFNmod treatment inhibited accumulation of CD163+MRC1- macrophages & reduced the expression of inflammatory mediators in this subset in BAL. Downregulation of genes related to inflammasome activation, stress response, and cell death was observed in lungs.