BrettBlakeley

Building @withSifted, turn screenshots into action
Scientist in AI drug discovery and indie builder

[BrettBlakeley @BrettBlakeley]

I’ve been thinking about this a lot lately:

screenshots aren’t really a way to remember things

they’re a way to not deal with something right now

this update is our attempt to make that actually work

[withSifted @withsifted]

See something on your phone you need to deal with… but don’t have time right now?

Screenshot it. Sifted takes it from there.

Big update today! Way more reliable, faster, and ready when you come back.

Available now on the App Store.

[BrettBlakeley @BrettBlakeley]

Summer blockbuster or 2026 headline?

Maverick intellectual invents world destroying technology. Government threatens the growth of the technology and prosperity of the creator. Backed into a corner and facing financial ruin, the creator turns to their invention for a solution…

[Derek Thompson @DKThomp]

This has quietly been a miracle month in medicine.

In the last 5 weeks we’ve got news on:

- retatrutide, the triple agonist GLP-1 from Lilly, basically melting fat and body-wide inflammation at record levels
- RevMed’s new pancreatic cancer drug showing unprecedented abilities to extend life
- small trial of a one-and-done PCSK9 gene editing therapy for slashing LDL cholesterol
- Mayo’s AI-assisted radiology showing vastly improved cancer detection
- this new therapy for metastatic solid tumors

This stuff is at varying levels of evidence. Retatrutide is ~100% on its way, other stuff needs more clinical trial data. But put it together and we’re maybe on the verge of majorly reducing the mortality of heart disease and cancer, the two leading causes of death in America.

[BrettBlakeley @BrettBlakeley]

You’re telling me there’s a giant space rock in cape cod bay right now⁉️

https://t.co/S8wRLprgqv

[BrettBlakeley @BrettBlakeley]

It would be a mistake to assume that 100% of text-based tasks happening across enterprises today are business critical

https://t.co/Ko0CoZxMWc

[Alex Blechman @AlexBlechman]

Sci-Fi Author: In my book I invented the Torment Nexus as a cautionary tale

Tech Company: At long last, we have created the Torment Nexus from classic sci-fi novel Don't Create The Torment Nexus

[BrettBlakeley @BrettBlakeley]

Careful out there vibe coding comrades 🫡

https://t.co/FeXDHwxv7o

[BrettBlakeley @BrettBlakeley]

Gell-Mann Amnesia is when you read an article in your expertise and spot all the flaws. Then read another article outside your field and trust everything

With LLMs, this is amplified

You catch errors in your domain, but accept the rest without scrutiny

Same model
Same limits

[BrettBlakeley @BrettBlakeley]

Today, a “thought leader” proclaimed, just like learning to code is becoming obsolete, soon AI will crack biology so we won’t need to learn that either

This extrapolation has never made sense to me

Biology isn’t logical. It’s messy, redundant, and full of hacks

A lazy analogy

[BrettBlakeley @BrettBlakeley]

Saying "this should be a short meeting" when the meeting starts is undefeated at ensuring the meeting goes to full time, usually longer

[BrettBlakeley @BrettBlakeley]

Stumbled upon a useful vibe coding technique this week

After fixing a bug, Opus 4.7 proposed architectural changes to prevent recurrence

Me: what if we do nothing?
O: if "do nothing" is on the table, that's probably best

It didn't consider "do nothing" as an option

[withSifted @withsifted]

Screenshots pile up.
Nothing happens after.
Sifted turns them into reminders, events, and next steps — automatically.

Live on Product Hunt today

https://t.co/W0RhGP5V9H

[BrettBlakeley @BrettBlakeley]

Screenshots are the fastest way to save something and a dead end right after.

Your camera roll fills up with things you meant to come back to.

We built Sifted to close that gap.

Launching today on Product Hunt

https://t.co/AGIZpKQgk1

[BrettBlakeley @BrettBlakeley]

Dunking on LLMs is fun, legit lol this tweet. It’s also a mistake to miss what’s actually happening: a new kind of intelligence, with a strength/weakness profile nothing like our own.

[Min Choi @minchoi]

Claude Opus 4.7 has achieved AGI

[Brandon Beylo @marketplunger1]

lol who did this.

[Jessica Nutt @JessicaNutt96]

Mythos is not a bad name for a model but it would be better if Anthropic switched to using famous Claudes. Monet, Debussy etc. The final model that achieves AGI would obviously be Van Damme

[𝚃 @T_wontmiss]

24 years old.
Fully paid off Costco hotdog.
It's not "parents money".
It's not luck.
It's consistency.
It's discipline.
I grind EVERYDAY to live this lifestyle.

[BrettBlakeley @BrettBlakeley]

Watching Opus 4.7 release with a Claude Pro subscription. Hoping Sonnet 4.7 drops soon!

[Jakub Lála 👨🏻‍🍳🥯 @jakublala]

alrighty, let's see....

[Luca Naef @NaefLuca]

2 years ago @mmbronstein and I put forth an idea called "Black-box data" - to rethink how data is generated for AI. Most domains don't have the luxury of the internet or the PDB and breakthroughs have been scarce. 2 years later we see this increasingly applied - now we wrote a perspective to highlight it.