Broad Institute

A multidisciplinary community of researchers on a mission to improve human health.

[BroadMPG @BroadMPG]

The recording of "Dissecting Noncoding Regulatory Elements to Understand the Logic of Gene Regulation” by @heejin_roh is now available: https://t.co/ZuPvlyklqo.

This talk is part of @broadinstitute's MPG Primer series. For more info, check out https://t.co/h21I2KmxQH

[Xavier Lab @TheXavierLab]

Excited to share this study in @CellCellPress with @mathildpoyet, @mgroussi and @ejalm, exploring how industrialization shapes host-microbiome interactions using multivariate data from the Global Microbiome Conservancy cohort!

https://t.co/GdK7nov5En

[Eric Topol @EricTopol]

Th distinct features of colon cancer in the young at single-nucleus resolution, both unfavorable and potentially helpful for understanding why this is on the rise @NatureMedicine
https://t.co/aOUDUNV80U

[Eric and Wendy Schmidt Center @Schmidt_Center]

🔬 New work from the @Schmidt_Center and @ETH_en shows that active adhesome genes and their regulators are spatially clustered in the nucleus, suggesting an association between chromatin organization and gene expression.

🔗 https://t.co/7SutKpO0nz

@broadinstitute

[Kimmie Ng, MD, MPH @KimmieNgMD]

Our atlas of young-onset CRC is finally out in @NatureMedicine! We found a unique biology in younger patients that may explain the aggressive nature of this disease. This was a monumental effort with colleagues at @MassGenBrigham and @broadinstitute. @DFarberYoungCRC

[Xavier Lab @TheXavierLab]

New paper in @NatureMedicine with @KimmieNgMD and @AnaAndersonlab! Early-onset colorectal cancer (#EOCRC) is rising. Our single-nucleus atlas of 189 tumors reveals age-associated differences and offers a resource for further research.
https://t.co/JEEAtbveWg

[Dana-Farber News @DanaFarberNews]

Researchers co-led by @KimmieNgMD of @DanaFarber and @DFarberYoungCRC created the largest single-cell atlas of colorectal cancer ever, identifying age-associated differences that may help research into why #colorectalcancer can be more aggressive in younger adults. ➡️https://t.co/vdThYcmZqO

[Broad Institute @broadinstitute]

More people younger than 50 are being diagnosed with colorectal cancer, and the disease is often more aggressive. A single-cell study of colorectal tumors reveals differences in cell composition and expression in tumors from younger patients. https://t.co/q8fmiWYjhS

[Human Cell Atlas @humancellatlas]

The 2027 HCA General Meeting will take place in The Hague, the Netherlands, on 29 June - 1 July. Early bird registration for the #HCA2027GM is now open and runs until 28 February 2027.
For more information and to register see https://t.co/4bbQvOYIcZ

[Broad Institute @broadinstitute]

Broad scientists discover that mechanism underlying Huntington’s disease in striatum is also present in the neocortex, suggesting that new drugs under development could potentially protect multiple parts of the brain. https://t.co/A3Vi2ZCn54

[Eric and Wendy Schmidt Center @Schmidt_Center]

Join the @Schmidt_Center on Tuesday, November 3 at 4:00 pm (🍪 at 3:30 pm) for our colloquium with @eliasbareinboim, Associate Professor, Dept. of Computer Science and Director, CausalAI Lab at
@Columbia.

Learn more and register: https://t.co/efxtm8IgX9

@broadinstitute

[Broad Institute @broadinstitute]

Now accepting nominations for the 2027 Merkin Prize — a $400,000 international award recognizing advances that improved human health through diagnosis, treatment or prevention of disease. ➡️ Submit by Dec 4, 2026: https://t.co/4QacXAfyno

[Xavier Lab @TheXavierLab]

Our latest analysis of microbiome-reactive T cells, which revealed a unique, pro-inflammatory TMIGD2-hi subset of Th17 cells that expands in IBD and enriches spatially at the epithelium, is now online @ImmunityCP!

https://t.co/LRiIIicfwr

[Pardis Sabeti @PardisSabeti]

1/7 🌾🐄  Our letter is out in @Science: AI biosecurity must include agriculture.

Recently biological AI has brought biosecurity to the center of public debate, but most attention is on human pathogens. Crops and livestock are a major blind spot. 🧵

Gift link: https://t.co/LxiPD5gKsk

@broadinstitute @sabeti_lab @JonxFeldman @talxfeldman

[Broad Institute @broadinstitute]

A cancer detection technology developed at Broad now powers a next-generation MRD test launched by Abbott. The Oncodetect® test is designed to find traces of cancer DNA in patients who have undergone treatment, and is the result of years of collaboration. https://t.co/WejAabVbP7

[Human Cell Atlas @humancellatlas]

To mark our tenth Anniversary month, watch HCA Co-Founder Aviv Regev reveal her hopes for the Human Cell Atlas initiative, and how it is already helping to improve medicine.
#HumanCellAtlas #Healthcare

[Human Cell Atlas @humancellatlas]

The integrated HCA v1 Human Gut Cell Atlas is now available on the HCA Data Portal! Integrating nearly 1 million single cells from 265 donors, the #Gut Atlas is a reference map to understand gut health and diseases like Crohn’s.

Explore here https://t.co/oCiO8sPlHO
#Genomics

[Broad Institute @broadinstitute]

Join us on Thurs. October 29, from 6-8 pm for Discovery After Dark! Experience science firsthand through interactive activities, take on the challenge of an Operation Outbreak simulation, and meet Broad scientists! Advanced registration required. Register: https://t.co/Ut3QP1rzzj

[Xavier Lab @TheXavierLab]

Applications are open for the Klarman Fellowship at @broadinstitute! We are looking for postdoctoral researchers to join the GaMBiT Initiative to develop innovative technologies that translate human genetic discoveries into disease mechanisms, biomarkers, and therapeutic leads.

[Human Cell Atlas @humancellatlas]

As we celebrate a decade of collaboration, HCA Co-Founder Sarah Teichmann shares why she and Aviv Regev joined forces to bring this international scientific consortium together. Hear Sarah tell the story.
@teichlab #HumanCellAtlas