Broderick Lab

Bioinorganic chemistry lab at Montana State University. Totally radical. Also, we ski. And fish. And hike. And camp. Lab-run account.

[J. Am. Chem. Soc. @J_A_C_S]

The [4Fe-4S] Cluster of HydF Is Essential for [FeFe]-Hydrogenase Maturation | Journal of the American Chemical Society https://t.co/ETO9H2KqT3

[Joan Broderick @joanbroderick]

Fantastic research group camping outing last weekend: two nights of a northern lights show, a beautiful float and card games. Perfect weather only a few days after an 8” snow storm. @BroderickLabFeS

[H.S. Shafaat @ShafaatLab]

Check out our #potw! Thanks Alina for presenting this cool work about a radical SAM epimerase by the Broderick lab. Read to learn how a conserved Cys to Ser mutation helped trap and characterize the α-C • intermediate of OspA using rapid quench & EPR
https://t.co/e1zjLMHzPy

[Piel Lab @piel_lab]

Congrats to @AnnaVagstad bringing this amazing story to the finish line! Thank you to everyone involved from @BroderickLabFeS for the fantastic collaboration! If you are interested in the enzymatic mechanism of peptide epimerization by rSAM, make sure to read it.👇

[Joan Broderick @joanbroderick]

Kudos to grad student Will Walls @BroderickLabFeS on outstanding work that led to his first @J_A_C_S paper! Congrats also to undergrad Tyler Delridge, Will Broderick, and collaborators @AnnaVagstad and @piel_lab. Radical epimerization in RiPP maturation.

[Joan Broderick @joanbroderick]

We showed that upon reductive SAM cleavage, the 5’-dAdo radical moves *towards* the [4Fe4S] cluster, on its way to forming the omega organometallic intermediate. The once elusive radical, triangulated! @BroderickLabFeS @MartinMosqueraT

[J. Am. Chem. Soc. @J_A_C_S]

ENDOR Spectroscopy Reveals 5′-Deoxyadenosyl Radical in a Radical SAM Enzyme Active Site is Chaperoned by Interaction with Methionine-Bound [4Fe–4S]2+ Cluster JACS @montanastate @NUChemistry @Northwestern #ENDOR #Adenosyl #Radical #Methionine #Chaperone https://t.co/8QCHgpUpCV

[Chemical Communications @ChemCommun]

New in ChemComm:

@joanbroderick and colleagues report the semisynthetic maturation of [FeFe]-hydrogenase, revealing new insights into the nature of H-cluster biosynthesis.

@BroderickLabFeS

https://t.co/JAhFu4jsQj

[J. Am. Chem. Soc. @J_A_C_S]

Computational Description of Alkylated Iron–Sulfur Organometallic Clusters | Journal of the American Chemical Society @montanastate @msuchembiochem @ResearchNU @NorthwesternU @NUChemistry #Computational #Alkylated #IronSulfur #Organometallic #Clusters https://t.co/yOZXZgPEKj

[Broderick Lab @BroderickLabFeS]

A new mini review from our lab focusing on in vitro [FeFe]-hydrogenase maturation. Interesting chemistry & biochemistry with still so much to learn!

[Angewandte Chemie @angew_chem]

[FeFe]-Hydrogenase In Vitro Maturation (Broderick) @BroderickLabFeS @joanbroderick https://t.co/Xr60eqrpqE

[Broderick Lab @BroderickLabFeS]

Happy to share our most recent review on radical SAM enzymes:
FEBS Press https://t.co/Welv5e8Tq9

[Joan Broderick @joanbroderick]

We have a fantastic department with so many amazing young faculty - come work in this stimulating and collegial community! Bozeman is not bad either!

[Sven T. Stripp 🇺🇦🔥🌊 @stripp_lab]

.@joanbroderick & gang review [FeFe]-hydrogenase in vitro maturation. Out now with @angew_chem! https://t.co/PkC4u5ul2I

[Broderick Lab @BroderickLabFeS]

We are working hard at the Metallocofactors GRC! #Metalloco22

[Broderick Lab @BroderickLabFeS]

Congrats to Katherine on graduating today with a B.S. in Chemistry/Biochemistry. She has been an awesome research student and lab mate and we will miss her!

[National Academy of Sciences @theNASciences]

Dana Longcope of @montanastate has been elected to the National Academy of Sciences for research on the nature of solar magnetism, and magnetic topology. #NAS159

Read more: https://t.co/bMRNU2Hm2R #physics

[National Academy of Sciences @theNASciences]

Congratulations to Joan B. Broderick of @montanastate who joins the National Academy of Sciences for her outstanding contributions to biochemistry. #NAS159

Read more: https://t.co/LJIsdZn9PN #biochemistry

[Broderick Lab @BroderickLabFeS]

Congratulations to Joan on election to the American Academy of Arts & Sciences! @americanacad @joanbroderick @msuchembiochem @montanastate

[American Academy of Arts & Sciences @americanacad]

Congratulations to the newly elected members of the American Academy! Today we are honored to welcome 261 exceptional individuals - including artists, scholars, scientists, and leaders in the public, non-profit, and private sectors - into the Academy.
https://t.co/7uJ8ygxxhd

[Sean Elliott @Prof_SJE]

A grad student interested in teaching positions? A post-doc looking to diversify? The @BUChemistry PAL program has been a successful way for training toward a PUI position! We are looking for 3 new PALs. You'll have a research and a teaching mentor! https://t.co/bDbRYW7T2I

[Angewandte Chemie @angew_chem]

[FeFe]-Hydrogenase: Defined Lysate-Free Maturation Reveals a Key Role for Lipoyl-H-Protein in DTMA Ligand Biosynthesis (Broderick) @BroderickLabFeS https://t.co/j7QmihPDym