Brunet Lab

Aging lab @Stanford - Epigenomics and metabolism in #aging; Brain aging and rejuvenation; Neural stem cells; C. elegans; African #killifish

[Brunet Lab @BrunetLab]

How do lipids influence aging?

We find that membrane lipid composition impacts neural stem cell aging and 'rejuvenation'!

HUGE congratulations to @xiaoaizh on her paper just published at @ScienceAdvances!! 🤩🍾

And a big thank you to all our collaborators!

A thread 🧵...

[Stanford Knight Initiative for Brain Resilience @BrainResilience]

Our Fall 2026 symposium is today! We look forward to scientific talks by:
🟣 Luigi Ferrucci — @NIH Aging
🟣 Botond Roska — @IOB_ch
🟣 @HolstegeHenne — @amsterdamumc
🟣 Ashley Webb — @BuckInstitute
🟣 Felix Boos — @StanfordMed Genetics
🟣 Yue Sun — Stanford Humanities & Sciences

[Anshul Kundaje @anshulkundaje]

I'm excited about this new class of generative models that allow us to understand how DNA sequence mediates regulation of transcription factor and nucleosome assemblies at single molecule resolution. 1/

[Alice Ting @aliceyting]

Interested in applying to Stanford Genetics PhD program? Join this informational zoom meeting with our department chair (Lars Steinmetz) and current Genetics grad students:

When: Thursday November 5
Time: 11 am-12 pm pacific time
Zoom link: https://t.co/AqdF7feEtU
Password: 535381

[Prof Steve Horvath @prof_horvath]

Epigenetic age is not a one-way street for the ovary. Sharif Iqbal and Vadim Gladyshev use pan-mammalian DNA methylation clocks to show ovarian epigenetic age runs in both directions: an old ovary placed in a young mouse becomes epigenetically younger. Conversely, a young ovary in an old mouse grows older. https://t.co/ddt9wHIPZp

[Itamar Harel @ItamarHarel]

1/2) Preprint alert!
How do embryos know when it’s time to wake up?
To uncover the molecular machinery behind this remarkable decision, we combined single-embryo RNA-seq with cross-species drug screens, revealing how HSP90 links temperature and hormone signaling to break dormancy

[Siegfried Hekimi @SiegfriedHekimi]

PhD position - September 2027

Our laboratory is looking for an additional PhD student to start in September 2027 to work on cell biology problems related to synthesis and intracellular trafficking of coenzyme Q in a variety of cellular and organismal systems.

[Brunet Lab @BrunetLab]

Fantastic Junior Group leader position at the Curie Institute in Paris!! Areas of interest include stem cells, tissue growth and morphogenesis, epigenetics, genomics, integrated physiology, metabolism, and synthetic embryo models. Please RT!
https://t.co/SoEq7CCete

[Brunet Lab @BrunetLab]

@longlabstanford @CellCellPress @Shuke_Xiao @alanshtung Congratulations Jonathan and team on this amazing study!! 🙌 😎 ✨

[Long Lab @longlabstanford]

Our work deorphanizing MCT6 as the missing gut Lac-Phe transporter is out today @CellCellPress: local gut lactate metabolism influences gut-brain crosstalk, and also explains metformin’s effects on body weight. Congratulations to @Shuke_Xiao @alanshtung!
https://t.co/7YLTKLlL0w

[Bonaguidi Lab @bonaguidilab]

Do astroglia have a role in human cognition? Our research reveals that an increase in abnormal astroglia is linked to age-associated decline in fluid intelligence.
https://t.co/Im7XTPvuzC
#Astrocytes #Cognition #Epilepsy #Aging #TranslationalNeuroscience #BrainHealth

[Andreas Tolias Lab @ Stanford University @AToliasLab]

Help us build the next frontier of AI, inspired by the brain. @naturecomputes and I are hiring a Chief of Staff at @metamorphiclabs ! If you’re high energy, super ambitious, and know how to get things done, apply. Please repost

[Brunet Lab @BrunetLab]

@TheVilchezLab Congratulations David and team!! Amazing work! ✨🙌

[David Vilchez @TheVilchezLab]

1/6 ❄️ Very happy to share our new study: “Cold activates a BH2 metabolic network promoting longevity and proteostasis.”
https://t.co/63BQK6AHUh
#Aging #Longevity #Proteostasis #Metabolism #ALS #HuntingtonsDisease

[Brunet Lab @BrunetLab]

@Sergiu_P_Pasca @theNAMedicine Congratulations Sergiu!! Super well deserved! ✨🤩🥂

[Brunet Lab @BrunetLab]

@ShilatifardLab Congratulations Ali!! So well deserved!! 😎🥂🤩

[Shilatifard Lab @ShilatifardLab]

Deeply honored to be elected to the National Academy of Medicine and grateful for all of the kind notes I have been getting from colleagues! https://t.co/fw72Z9RL7W This recognition belongs to the extraordinary people who made this journey possible—my laboratory members, past and present, my colleagues at Northwestern, National Cancer Institute for funding my work for the past thirty-plus years, the visionary philanthropists who believed in our science, and my wife and our four children, whose love, patience, and unwavering support have made everything possible. Science is a team endeavor, and I feel enormously fortunate and grateful. I truly am one of the luckiest people alive. @NU_BMG_SQE @NUFeinbergMed @NorthwesternMed @theNASciences @theNAMedicine @NIH @theNCI

[Semir Beyaz @beyazlab]

Our new paper in @NatImmunol explores this question through PPARδ, a lipid-sensing transcription factor that we identify as a regulator of the #fitness balance between #cancer and #immune cells. You can read the open access paper here: https://t.co/7iYvfAR0M6

[Ali Max Erturk @erturklab]

Brain vascular aging isn’t a single path. Our new work shows that the aging brain diverges into two states:
🧠 Hypovascular (expected)
🧠 Hypervascular (surprising), with BBB leakage, inflammation and cognitive decline.
Our study👇🏻: https://t.co/ob00oHR43C

[Ali Max Erturk @erturklab]

We recently introduced DISCO-seq 🤩: scRNA-seq after tissue clearing 🧬
https://t.co/r0JewTn5yC
First, image whole organs or bodies in 3D at cellular resolution. Then select regions for unbiased scRNA-seq.
From glioblastoma to whole-body SARS-CoV-2 spike mapping 👇🏻 #DISCOseq

[Brunet Lab @BrunetLab]

@AmarSahay_ Congratulations Amar and team!! Awesome work!! 🥂😎