@RicardoIRdz@LatinXChem@LondonMetCPS About the efficiency of the protocol, how many mmoles are you able to produce of 3a in 4 hours ? While the size of the CSTRs limited our ability to scale up the reaction, we successfully produced gram-scale quantities, achieving up to 15 mmol (just over 3.5 grams) in 4 hours.
@SumbalSaba@LatinXChem@LondonMetCPS Hi Sumbal, thanks for your question!
DBN only gets recycled for the hydroxyphosphonate, but for the substituted aryl phosphate and the aryl phosphate it gets completely utilised in the reaction.
Hope this answers your question!
@gabonney@LatinXChem@LondonMetCPS Hi George, thank you for your insterest in the work!
And you are definetly right—paraoxon is highly toxic and a known nerve agent simulant, so extreme care is needed. Proper safety protocols are essential when handling such hazardous materials in a lab. Safety first!