Butler Lab @ UCSB

Genome mining for unwinding iron binding. #BioInorganic #Chemistry, #Bioinformatics, #Biosynthesis

Student run, opinions our own.
IG: butlerlabucsb

[ACS Central Science @ACSCentSci]

Grab ‘n go: siderophore-binding proteins provide pathogens a quick fix to satisfy their hunger for iron!

Read #FirstRxns https://t.co/jsbFLVrlNF by @ADGallo56 & Katherine Franz @FranzLabDuke on the research by the Wencewicz Lab
@WashUChem https://t.co/1ixmwJR8aq

[Jen Heemstra @jenheemstra]

Bragging about huge numbers of hours worked each week misses two important truths:
-time at work doesn’t necessarily equal productivity
-there is no prize for suffering the most

[UC Santa Barbara @ucsantabarbara]

.@UCSB_chemistry’s graduate students recently discovered a technique to decipher siderophore's 3D structure. A better understanding this compound potentially means thwarting bacterial growth and treating certain illnesses. Findings appear in @PNASNews. https://t.co/WisCfVe8WU

[Butler Lab @ UCSB @ButlerLabUCSB]

"Mentoring: Reflections and Suggestions" -- Don't miss this editorial by Harry Gray, pioneer of #bioinorganic chemistry. Alison is a proud member of Gray Nation!

[Butler Lab @ UCSB @ButlerLabUCSB]

We're lucky to have Rich in our department!

[UC Santa Barbara @ucsantabarbara]

Working with just his hand and a very hot flame, #UCSB's in-house glassblower Richard Bock shares his expertise on this niche profession. https://t.co/nHxUBGh7Vr

[Butler Lab @ UCSB @ButlerLabUCSB]

Cool! Drosophila melanogaster has a nonribosomal peptide synthetase!

https://t.co/efKtRG1vMS

[Butler Lab @ UCSB @ButlerLabUCSB]

#UCSB colleagues, sign ups are open for the 2019 Out List! Please consider coming out as member of the LGBTQIA community, or even as a supporter. Visibility matters!

@ucsantabarbara @ucsb_rcsgd

https://t.co/Zmel11hHIn

[Butler Lab @ UCSB @ButlerLabUCSB]

@jwilcoxen @pinenut666 @rdavbritt NSF broader impacts. A significant portion of our grant money goes to promoting tweets and buying followers, but the influencer points make it worth it.

[Butler Lab @ UCSB @ButlerLabUCSB]

@DiannePater I'm still waiting for my check from big pharma for supporting vaccinations. Maybe they have the wrong address...

[Butler Lab @ UCSB @ButlerLabUCSB]

@MsHardy123 Stay tuned for a more accessible write-up!

[Butler Lab @ UCSB @ButlerLabUCSB]

🚨 NEW PAPER ALERT 🚨 Our latest work on amino acid β-hydroxylation in #siderophores is online!

https://t.co/Kd37JZ9JvX

[Butler Lab @ UCSB @ButlerLabUCSB]

@MsHardy123 Make @CliffHardy4 explain it to your students!

[Chemjobber @Chemjobber]

When you finish a PhD in chemistry they take you in a special room and tell you that tenure-track professorships aren't real and all professors are just really old postdocs.

I am posting this at great physical risk to myself and my family.

https://t.co/nhmEaMY6K6

[Butler Lab @ UCSB @ButlerLabUCSB]

When you finish a PhD in chemistry they take you in a special room and tell you that the periodic table isn't real and all matter is just made of the elements earth, air, fire, and water.

I am posting this at great physical risk to myself and my family.

[Butler Lab @ UCSB @ButlerLabUCSB]

To sum up, we can now predict the residue selectivity and stereospecificity of any siderophore β-hydroxylase. Although mechanistic questions remain, structures can now quickly be predicted just by looking at the gene cluster, or better yet, by using the pHMMs provided. (11/11)

[Butler Lab @ UCSB @ButlerLabUCSB]

To confirm that we could actually use these trees to predict siderophore structures, Cliff, Jae, and Jean isolated four siderophores and stereochemically characterized the OHAsp residues. Each matched the subtype-based prediction! (10/11)