Chris Anderson

Cerebrovascular health enthusiast. BWH/Harvard/Broad Institute. My expressed opinions are solely my own.

[Marios Georgakis @MariosGeorgakis]

Among the things hospitals teach you is a deep respect for disease. It is really hard to move the needle. We won't "cure all disease in 10 years". And there's a good change that medicine will still look much the same a decade from now.

[Stroke AHA/ASA @StrokeAHA_ASA]

#STROKE: In patients with acute ischemic stroke, admission NT-proBNP may predict the in-hospital development of atrial fibrillation detected after stroke (AFDAS), and a threshold of 505 pg/ml confers good discriminatory value. #AHAJournals https://t.co/3IAFCL6Sc9

[Pavlos Myserlis @PMyserlis]

@MariosGeorgakis @dpsg108 @JRosand_MD @drcbanerjee @CDAndersonMD @MuscNeurology Thank you Marios!

[Benjamin Tan @DrBenjaminTan]

Our study in @NephrologyJourn explores the interplay between #CKD and ischemic #stroke. Findings highlight the need for integrated care strategies to improve outcomes and reduce stroke risk in CKD patients. @leonardyeo1 @ClaraNgoh @CDAndersonMD

https://t.co/p6UWxtVQCO

[Marios Georgakis @MariosGeorgakis]

Spatial proteomics in human carotid atherosclerotic plaques (N=118). A great weekend read❗️

👉subregions isolated with microdissection (lipid core, fibrous cap, tunica media)
👉mass-spec proteomics
👉proteome-defined subclusters across subregions
👉biological enrichment across subclusters
👉associations with instability features
👉predictions of unstable vs. stable plaque
👉correlations with plasma proteome

[Chris Anderson @CDAndersonMD]

Thanks Tom. You’ve done so much for the field that I appreciate this tremendously.

[Tom Van Agtmael @TomVanAgtmael]

New review article by Chris Anderson @CDAndersonMD on Genetics of intracerebral hemorrhage
https://t.co/ne8kIneLg6

[Marios Georgakis @MariosGeorgakis]

Another key resource for CNS genomic and drug target discovery research❗️

👉pQTLs for 6,361 CSF proteins (SomaScan aptamers)
👉N=3,506 samples
👉3,885 associations for 1,883 proteins

📜paper: https://t.co/1oS9Jty3uC
📊summ stats: https://t.co/P48e0oCwNF

[Carlos Cruchaga @ccrugom]

We made a lot of effort to put all summary statistics available. There are in four different places: 1) NIAGADS: https://t.co/ic2z8MrZ1T, 2) GWAS catalog, GCST90317902–GCST903193033, 3) Pheweb browser https://t.co/LTkW5oxVbP, and 4) our website: https://t.co/ZUVkmeVeO4

[Chris Anderson @CDAndersonMD]

You're never behind the genetic 8-ball. Making healthy lifestyle choices reduces your risk of age-related brain disease even if you have a genetic predilection. https://t.co/SWT6wSB37k. @BWHNeurology @MGHNeurology @CGM_MGH @broadinstitute

[Marios Georgakis @MariosGeorgakis]

Comprehensive proteome-wide Mendelian randomization for 355 phenotypes in 3 ancestries

👉N=35,559 European, 1,871 African, 1,823 East Asian
👉SomaScan & Olink
👉extensive sensitivity analyses

📊Results browsable here: https://t.co/Sw8ZsjbG8J
📰Preprint: https://t.co/khUzeNdWyr

[Murad @Murad__Omarov]

I extend my deepest gratitude to my co-authors @rainermpg, @sdorodgar, @VineetRaghu2, @pnatarajanmd, @BellomoTiffany, and @CDAndersonMD for their invaluable contributions, and especially to my PI @MariosGeorgakis for making this possible and for his immense support

[Marios Georgakis @MariosGeorgakis]

Many cool findings & a great resource for future research in atherosclerosis

📊GWAS summ stats to be posted on @GWASCatalog

Phenomenal work by star @Murad__Omarov⭐️

Great collaboration with @CDAndersonMD @rainermpg
@sdorodgar @VineetRaghu2 @pnatarajanmd @BellomoTiffany

[Shaan Khurshid @shaan_khurshid]

Many thanks to study co-authors @lucidtronix, @ShinoKany, Rahul Mahajan, Clay Turner, @steven_lubitz, @MahnazMaddah

and 🙏 as always for mentorship @patrick_ellinor, @CDAndersonMD

@broadinstitute @MGHHeartHealth @MassGeneralNews

[Marios Georgakis @MariosGeorgakis]

🚨Postdoc Opening🚨

We're seeking a skilled scientist to lead research in multiomics❗️

Join our excellent interdisciplinary team👇in our efforts to tackle pressing challenges in cardiovascular disease

Lab: https://t.co/lWl8pe5AbM

Position: https://t.co/gumHahkZ58

Please RT!

[Pavlos Myserlis @PMyserlis]

- While the protective role of GFAT on CVD risk is mediated predominantly by common vascular risk factor modification (SBP, T2DM, LDL), residual mediatory effect may be exerted by adipose-specific factors, suggesting that targeting those may provide additional vascular benefit

[Marios Georgakis @MariosGeorgakis]

The effects of a polygenic risk score for BMI on obesity and obesity-related morbidities are offset by a healthy lifestyle 🧬🍲🏃‍♀️

👉evidence of additive & multiplicative interaction
👉high PRS ⬆️ the effect of unhealthy lifestyle on obesity risk

https://t.co/1CTZzhmsCr

[Chris Anderson @CDAndersonMD]

@MIT_CSAIL @gp_pulipaka T-shirt material. Happy place.

[Chris Anderson @CDAndersonMD]

Honored to have you join the faculty Priya. Great things now and ahead.

[Brigham and Women's Neurology @BWHNeurology]

#NewFaculty Dr. Priya Srikanth will join the Divisions of @BWHNeuroICU and Neurorecovery at @MassGenBrigham on July 1. Welcome, Priya!

[Marios Georgakis @MariosGeorgakis]

GWAS of 2024 AI-derived (mainly imaging) human disease endophenotypes, including genetic correlations and Mendelian randomization associations with disease endpoints🧬

Summary stats to be made available upon publication

https://t.co/My7Jo8xiWi

[Pradeep Natarajan @pnatarajanmd]

Excited to share our study investigating the genetics of combined lipid patterns led by @tgillilandmd @jsdron! https://t.co/byTx0y9ygS @CircRes

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