Prof Cheng-Hock Toh CBE

🩸Physician #thrombosis #transfusion |🩸Researcher #sepsis #histones | Chair - National 🩸 Transfusion Committee

[The BMJ @bmj_latest]

Tranexamic acid safely reduces surgical bleeding and the need for blood transfusion.

Greater use of tranexamic acid in surgery is important, especially in low and middle income settings where blood stocks are lower and risks higher, says Analysis https://t.co/I2AsfPBxWi

[Royal College of Anaesthetists @RCoANews]

Use of TXA is @NICEComms quality standard but 1/3 of patients who should receive TXA are not treated.
Full compliance would:

✔️ Prevent 15,000 major surgical bleeds

✔️ Avoid the transfusion of 33,000 units of blood

✔️ Save 45,000 hospital days & millions of £ for the NHS

[Royal College of Anaesthetists @RCoANews]

Use of TXA is also recommended by:

✔️ The #InfectedBloodInquiry

✔️ @CPOC_News 'Anaemia in the Perioperative Pathway' Guideline

✔️ Our Perioperative Quality Improvement Programme @PQIPNews

[Royal College of Anaesthetists @RCoANews]

We recommend that tranexamic acid (TXA) is considered in all adult surgical patients & administered if more than 500ml of blood loss is likely. This should be added to surgical checklists. 🧵

The benefits are presented in this open access BMJ article: https://t.co/bTYCyl2eA6

[JTH @JTHjournal]

Major gaps in current understanding of coagulation and the pressing need for improved diagnostics and therapeutics lead @CHToh1 and @yongjxjason to propose a new convergent model of coagulation that integrates inflammation and innate immune activation.
https://t.co/TsutYTMcYU

[JTH @JTHjournal]

Fibrinogen buffers the cytotoxicity of circulating histones in vivo and ratios of histones to fibrinogen help identify critically ill patients at highest risk of mortality, who might benefit from anti-histone therapy.
@CHToh1 @stabrams @yongjxjason
https://t.co/dFR7Klnl44

[JTH @JTHjournal]

Fibrinogen buffers the cytotoxicity of circulating histones in vivo and ratios of histones to fibrinogen help identify critically ill patients at highest risk of mortality, who might benefit from anti-histone therapy.
@CHToh1 @stabrams @yongjxjason
https://t.co/dFR7KlmNew

[Prof Cheng-Hock Toh CBE @CHToh1]

👏🏻👏🏻True stalwart and he holds the secret to eternal youth

[Thomas Reiser @TomReiser]

The @isth would not be the same w/out our wonderful & dedicated staff. No one embodies this more than our one-and-only @rcaryclark Dir. Programs & Education. Read his perspective in today's Congress Daily https://t.co/kadwbat65e
Thank you for all you do for ISTH! #isth2024

[The BMJ @bmj_latest]

The NHS has made an urgent appeal for O blood type donors in response to the cyberattack that forced some of the largest hospitals in London to cancel operations and divert patients to other trusts
https://t.co/p5anQ2brNW

[The BMJ @bmj_latest]

The final report of the UK Infected Blood Inquiry exposes the catastrophic failings that devastated lives through transfusion transmitted HIV and hepatitis viruses.

Even now, transfusion practices could and should be safer, say @CHToh1 @Elisagree https://t.co/E6ML1Ph0cZ

[The BMJ @bmj_latest]

Profound harm has been done to the individuals and families affected by infected blood.

For many, the inquiry’s report has sadly come too late, but its recommendations can still stop a growing complacency over transfusion practices @CHToh1 @Elisagree
https://t.co/E6ML1Ph0cZ

[Prof Cheng-Hock Toh CBE @CHToh1]

1. Research improves patient outcome
2. Research improves doctors satisfaction

Check out https://t.co/7fAGNUYBRh

@RichardHaynes3 @MartinLandray

[Royal College of Physicians @RCPhysicians]

Writing in @bmj_latest, former RCP academic vice president Prof Cheng-Hock Toh CBE (@CHToh1) and colleagues describe the ‘rewarding and worthwhile career’ that clinical research can offer to doctors:

https://t.co/EkjZkcpE5W

[Royal College of Physicians @RCPhysicians]

Writing in @bmj_latest, former RCP academic vice president Prof Cheng-Hock Toh CBE (@CHToh1) and colleagues describe the ‘rewarding and worthwhile career’ that clinical research can offer to doctors:

https://t.co/EkjZkcpE5W

[Medical Schools Council @ukmedschools]

MSC has published its findings on the 2023 clinical academic survey, revealing an ageing workforce and continuing gender and ethnic imbalances in clinical academia.

Press release: https://t.co/1937d0UN4R
Interactive tool: https://t.co/RoV1VpfSKN

[Pip Nicolson @PipNicolson]

Delighted to make the front cover of the ⁦@bmj_latest⁩ today. Thank you ⁦@CHToh1⁩ for your support in developing this manuscript and for your support in initiating and growing ⁦@HaemSTAR_UK⁩

[Prof Cheng-Hock Toh CBE @CHToh1]

Amazing to be alongside @ProfMakris. He’s a most generous friend since being fellow Haematology Registrars at Sheffield #BSH2024 @BritSocHaem

[BSH - Haematology @BritSocHaem]

Welcome to day two of the #BSH24 #ASM

A quick look back to yesterday and a massive congratulations to our BSH Lifetime Achievement Award winners; Mike Makris @ProfMakris and Cheng Hock-Toh @CHToh1

See our interview with Cheng Hock-Toh here: https://t.co/EbC3dNjVp7

[Liverpool University Jobs @livunijobs]

📢We're seeking an enthusiastic #PDRA to join the team of Professor Cheng-Hock Toh on an NHS founded project in partnership with the Cryo-EM team of Leeds University.
Information / Apply ➡️https://t.co/XOjsx8Dy45
@LivUni_IVES @LivUniHLS @LivUniResearch

[University of Liverpool News @livuninews]

A recent paper in @JTHjournal illustrates research by @LivUni researchers to understand the mechanisms causing rare adverse reactions following the COVID vaccination.

Read the paper here⬇️

https://t.co/mSidrKAMBU

[Prof Cheng-Hock Toh CBE @CHToh1]

@BritSocHaem A testament to #coagulation research in #liverpool: 1 in 2 of top T&H orals at #BSH24 are #liverpool doctors in training

[JTH @JTHjournal]

For #aprilfoolsday #Coverart
Adenoviral vector-based #COVID19 #VITT is rare but carries significant risks of mortality and long-term morbidity.

Abrams et al @CHToh1 find 📈proinflammatory cytokines & Thelper 1/2 activation.

#CovidVaccines

https://t.co/31PwFN7FFl