Co-published by @ACPinternists and @AHAScience#AHAJournals, @AnnalsofIMCC is a peer-reviewed, open access journal that publishes #casereports, case series, and image/video cases across the spectrum of medicine. Learn more and submit to AIMCC today at https://t.co/IzoNqdQ2Qo
The CKM Syndrome Guideline will shape how healthcare professionals approach prevention and care. Hear directly from the experts on translating it into practice.
Meet the experts who will unpack the science and discuss real-world applications at the upcoming live event.
@LisaVWMD@HeartDocSadiya@ambarkul@PowellWileyLab@NutritionHF@ChiadiNdumele
Endothelial SHMT2 drives pulmonary vascular remodeling via the SHMT2βBRISCβRhoB axis. Namodenoson inhibits this pathway with in vivo efficacy and an established clinical safety profile.https://t.co/jDF9LG3Jyl
RND3 was identified as a novel mitochondrial matrix-resident small GTPase essential for energy metabolism homeostasis and normal cardiac function, with potential as a therapeutic target in ischemia-reperfusion injury.https://t.co/thuAKHQa1t
In a multicenter PET registry, patients with no evidence of flow-limiting CAD and discordantly low subendocardial myocardial flow reserve (MFR) had an increased risk of MACE than those with normal transmural & subendocardial MFR. https://t.co/jd8O5TIHnj
Mutations in Notch transcriptional coactivator MAML1 directly recapitulated VSDs in models.
Dysregulation of liquid-liquid phase separation impaired Notch signaling, establishing link between condensate dynamics & congenital disease. https://t.co/9aNXNNC3D2
Alternative splicing of Tropomyosin 1 (TPM1b) exon 9a is a pathogenic mechanism in myofilament disorder and diastolic dysfunction in HFpEF and is mediated by SRPK3. This may represent a novel therapeutic target for HFpEF.https://t.co/vSPCP57Xea
HIF-2 drives coronary inflammation, remodeling, and thrombosis in a novel mouse model recapitulating Kawasaki disease. Pharmacological HIF-2 targeting may be a new therapeutic strategy for coronary vasculitis. https://t.co/BvBGjXCdpS
Common African ancestry-enriched variants of uncertain significance associated with increased cardiomyopathy and arrhythmia risk, particularly in individuals with CV risk factors or HF. https://t.co/JcqzeQjj2z