Caitlyn Holmes. Incoming Assistant Professor at the U of Minnesota studying Klebsiella-host interactions. Postdoc: Bachman Lab. Alum: UW-Madison, UCF. #KlebClub
An Update! 🎉 I am so happy to announce that in May 2025, I will be joining the University of Minnesota as an Assistant Professor in the Department of Microbiology & Immunology. My lab will study host-pathogen interactions during Klebsiella systemic infection.
Thank you to all collaborators for helping to sort through this huge set of data and to the barcoding community for your help in comparing our trends to other systems! This is truly a study were I made friends and collaborators along the way. ⭐
I'm excited to announce our latest publication! We teamed up with @KHullahalli to barcode Klebsiella and ask basic questions about bacteremia pathogenesis: 1) how are bacteria shared between sites and 2) which host and bacterial factors influence dynamics?
https://t.co/Ajdjyu0QUX
Klebsiella leaves the lung in two distinct patterns, termed "metastatic" and "direct", which are defined by the extent of clonal replication in primary tissues and predict bacterial burden across sites. Oxidative stress from the host and bacterial LPS influences these patterns.
It's that time of year! Registration and abstract submission for the 6th Klebsiella Seminar Series is now open. Participation is free and abstracts are due by February 16th. See the link below for details:
https://t.co/vOKIxqXJas
#KlebClub
@minisciencegirl Thank you, Amy! That is so kind. The STAMPR work has been a fun thought exercise in how infections progress and how bacteria need to adapt to spread between tissues. Certainly a huge collaborative effort!
I'm so happy that this paper is finally published! This one was a long time coming: 9 years, 3 pairs of hands, 270 strains, 93 plasmids, and a lot of hard work. It started as a side project that eventually led to my entire dissertation, and I'm glad it did.
@KhaderShabaana Tips for personnel management would be helpful! For example, how to set group/individual expectations, handle conflict between lab members, or conduct annual reviews. It would be nice to hear a few different strategies for these types of things since everyone does it differently.
New article!✨In this review, we present a broad overview of bloodstream infections, consider microbial pathogenesis mechanisms, and discuss how these strategies could be used in future therapies. #KlebClub
Bloodstream infections: mechanisms of pathogenesis and opportunities for intervention
Holmes, Bachman & co. explore major pathogens causing bloodstream infections, their pathogenesis, opportunities for prevention, diagnosis & treatment options.