COGA

The Collaborative Studies on the Genetics of Alcoholism (COGA) is an 11 center research project designed to understand the genetic basis of alcoholism

[COGA @COGA_alcohol]

Learn more about the understanding of the genetic factors in OCD and supports future treatment developments 👉 https://t.co/AIdAEjMPCz

[COGA @COGA_alcohol]

ɴᴇᴡ ᴄᴏɢᴀ ꜱᴛᴜᴅʏ: Genome-wide Association Study Identifies 30 Obsessive-compulsive Disorder Associated Loci 🧠📷🧬👉https://t.co/AIdAEjMPCz

[COGA @COGA_alcohol]

Researchers combined data from 53,660 OCD cases and 2,044,417 controls of European ancestry, identifying 30 genetic markers strongly associated with OCD and finding that genetic factors explain 6.7% of the risk.

[COGA @COGA_alcohol]

Researchers combined data from 53,660 OCD cases and 2,044,417 controls of European ancestry, identifying 30 genetic markers strongly associated with OCD and finding that genetic factors explain 6.7% of the risk

[COGA @COGA_alcohol]

Obsessive-compulsive disorder (OCD) affects approximately 1% of the population and has a strong genetic component.

[COGA @COGA_alcohol]

Results were evaluated by bootstrap methods. Males and females show similar covariance patterns over time, but structures differ. Region differences within sexes exceed those between sexes. Read more: https://t.co/byUQthC8PF

[COGA @COGA_alcohol]

ɴᴇᴡ ᴄᴏɢᴀ ꜱᴛᴜᴅʏ: Non-linear Development Of EEG Coherence In Adolescents And Young Adults Shown By The Analysis Of Neurophysiological Trajectories And Their Covariance 🧠📈👉 https://t.co/byUQthC8PF

[COGA @COGA_alcohol]

They looked at specific brain activity (high alpha frequency) across 27 pairs of brain regions, resulting in 5006 observations.

[COGA @COGA_alcohol]

Two recent studies demonstrated that the risk for alcohol-related problems in young adult drinkers could be blunted by teaching them how to modify three characteristics that increase the impact of a low alcohol response on future problems. Read more: https://t.co/MgEEBI3gpB

[COGA @COGA_alcohol]

ɴᴇᴡ ᴄᴏɢᴀ ꜱᴛᴜᴅʏ: Predictors of Risk and Resilience for Future Alcohol Problems Associated with a Low Level of Response to Alcohol📊 🧬 👉https://t.co/MgEEBI3gpB

[COGA @COGA_alcohol]

Researchers investigated future prevention protocols for reducing heavy drinking and alcohol-related issues in individuals with a low response to alcohol, a genetically influenced risk factor for recurring alcohol problems.

[COGA @COGA_alcohol]

ɴᴇᴡ ᴄᴏɢᴀ ꜱᴛᴜᴅʏ: A Critical Review Of Ethanol Effects On Neuronal Firing: A Metabolic Perspective 👉 In this article, we dive into recent investigations of ethanol over glucose as a carbon and energy source by neurons: https://t.co/sh1P4xCs18

[COGA @COGA_alcohol]

Interestingly, when Principal Component Analysis (PCA) is applied to real data from COGA, we found that using certain statistical factors helped reduce bias related to tobacco use.

[COGA @COGA_alcohol]

ɴᴇᴡ ᴄᴏɢᴀ ꜱᴛᴜᴅʏ: Principal Component Analysis Corrects Collider Bias in Polygenic Risk Score Effect Size Estimation 📊 🧬 In this article, researchers explore an approach to correct collider bias persisting in existing cohort studies: https://t.co/ouOAuEoMuO

[COGA @COGA_alcohol]

However, statistical models, crafted to eliminate alternative explanations for associations between genetic risk scores and these traits, face potential bias if the alternate explanation is also influenced by the genetic risk score.

[COGA @COGA_alcohol]

ɴᴇᴡ ᴄᴏɢᴀ ꜱᴛᴜᴅʏ: Genomic Analysis Of 1.5 Million People Uncovers Genes Related To Addiction, Antisocial Behavior, And Disease 🧬🧠 This research sheds light on the intricate genetic nature of externalizing traits: https://t.co/BP8SjStrNM

[COGA @COGA_alcohol]

Open Access reviews of @COGA_alcohol are now on line: overview https://t.co/L2Qa8LpmCM, sample https://t.co/u03lhq9VpE , brain function https://t.co/BCUkxCIpL2, genetics https://t.co/VG8YrKRT86, and functional genomics https://t.co/uj0ES0CXo3. 2/2

[COGA @COGA_alcohol]

Alcohol Use Disorder (AUD) is a complex genetic disorder, involving genetic, neural, and environmental factors. The Collaborative Study on the Genetics of Alcoholism (@COGA_alcohol) is a family based, diverse sample with multi-modal data on 17,878 individuals. 1/2