COVID-19 Literature Surveillance Team

We find the latest #COVID19 articles, read them, grade their level of evidence, and bring you the bottom line up front. Check out our report and weekly podcast.

[COVID-19 Literature Surveillance Team @COVID19LST]

In a #systematicreview of patients who recovered from #COVID19, researchers at the Health Information and Quality Authority in Ireland found reinfection rates to be 0–1% with no studies showing increased infection risk w/ increasing time since recovery.
https://t.co/wHbxWjnqic

[COVID-19 Literature Surveillance Team @COVID19LST]

A cross-sectional study conducted at the Beijing Institute of Microbiology and Epidemiology suggests that immunity against #COVID19 after infection largely persists at about one year, though a small sample size warrants future large-scale studies.
https://t.co/wHbxWjnqic

[COVID-19 Literature Surveillance Team @COVID19LST]

Investigators at the Institute for Basic Science in South Korea found nasal ciliated cells are primary targets for #SARSCoV2 replication in the early stage of #COVID19, but requires further study.
https://t.co/wHbxWjnqic

[COVID-19 Literature Surveillance Team @COVID19LST]

A U.S. research team used a multinational, placebo-controlled, observer-blinded trial to determine the BNT162b2 #COVID19 #vaccine in 12-to-15-year-olds produced greater immune response than in young adults & was shown to be both safe and highly effective.
https://t.co/XzE7uZDIHP

[COVID-19 Literature Surveillance Team @COVID19LST]

A multi-center retrospective cohort study conducted by the CDC COVID-19 Response Team and U.S. Public Health Service Corps found increased risk of severe adverse outcomes in #pregnant patients was associated with #COVID19 in 6,550/489,471 patients.
https://t.co/XzE7uZDIHP

[COVID-19 Literature Surveillance Team @COVID19LST]

A study of 84 breastfeeding women who received the Pfizer-BioNTech #vaccine found positive levels of anti-SARS-CoV-2 IgG antibodies in 91.7% of breast milk samples at week 5 and 97% in weeks 5-6 after 1st dose, suggesting possible protection for infants.
https://t.co/XzE7uZDIHP

[COVID-19 Literature Surveillance Team @COVID19LST]

Brazilian researchers assessed the efficacy of methylprednisolone (MP) in treating hospitalized #COVID19 patients and found no significant difference in 28 day mortality, though post hoc analysis revealed lower mortality in ages over 60 in the MP group.
https://t.co/XzE7uZDIHP

[COVID-19 Literature Surveillance Team @COVID19LST]

In a cohort study at Stanford, 23% of plasma samples from patients in the ED with #COVID19 had viral RNA detected by digital PCR compared to 1.4% by quantitative PCR. RNAemia indicated more severe disease & could serve as an indicator for earlier therapy.
https://t.co/L0rzDNHH6T

[COVID-19 Literature Surveillance Team @COVID19LST]

Researchers in Jerusalem investigated efficacy of the BNT162b2 vaccine in health care workers. #COVID19 rates decreased 4 weeks post-vaccine despite B.1.1.7 variant surge, suggesting the #vaccine is effective in high-incidence areas and against variants.
https://t.co/L0rzDNHH6T

[COVID-19 Literature Surveillance Team @COVID19LST]

The CDC discuss adverse effects of the Janssen vaccine in the Vaccine Adverse Events Reporting System, which received 17 reports of thrombosis with thrombocytopenia syndrome (TTS), only 3 of which were due to non-cerebral venous sinus thrombosis etiology.
https://t.co/L0rzDNHH6T

[COVID-19 Literature Surveillance Team @COVID19LST]

An analysis by Grenoble Alpes University Hospital of adverse reactions included 844 facial paralysis-related events after the Pfizer or Moderna #COVID19 vaccines but showed no increased incidence of facial paralysis compared to other viral vaccines.
https://t.co/L0rzDNHH6T

[COVID-19 Literature Surveillance Team @COVID19LST]

Univ. of Manitoba researchers conducted a #systematicreview and meta-analysis on 5 studies of remdesivir use in #COVID19. A 10-day course didn't show a mortality/clinical benefit. 5-day course showed improvement, but sequential analysis was inconclusive.
https://t.co/L0rzDNHH6T

[COVID-19 Literature Surveillance Team @COVID19LST]

A retrospective study on 45,162 healthcare personnel (HCP) found Pfizer and Moderna #COVID19 #vaccine effectiveness was 78% for partial vaccination and 96% for complete vaccination after adjusting for age, gender, region, job, and week of vaccination.
https://t.co/Z41fJuOLJd

[COVID-19 Literature Surveillance Team @COVID19LST]

A #systematicreview and meta-analysis conducted by researchers in China included 14 studies and found a prevalence of 0.774% and mortality rate of 8.814% of #COVID19 infection among people living with HIV/AIDS.
https://t.co/Z41fJuOLJd

[COVID-19 Literature Surveillance Team @COVID19LST]

Epidemiology experts from University of Sousse, Tunisia conducted a #systematicreview and meta-analysis and determined the mean and median incubation period of #COVID19 was 8 days and 12 days, respectively. #SARSCoV2
https://t.co/Z41fJuOLJd

[COVID-19 Literature Surveillance Team @COVID19LST]

Multiple experts state that two-dose vaccines have the strongest antibody response and can be more effective against variants, while passive antibody therapy can be used to prevent and treat #COVID19 in immunocompromised people.
LEVEL OF EVIDENCE: 5
https://t.co/yil8dqWQag

[COVID-19 Literature Surveillance Team @COVID19LST]

A systematic review by researchers at Tufts analyzed studies about #SARSCoV2 surface stability and indicated a half-life of 2.3-17.9 hours on stainless steel, plastic, and nitrile that decreased with higher temperature and humidity. LEVEL OF EVIDENCE: 1
https://t.co/yil8dqWQag

[COVID-19 Literature Surveillance Team @COVID19LST]

A systematic review by immunology specialists in Iran shows that symptoms and prognosis of pregnant women with #COVID19 are similar to the general public, but monitoring is crucial for the health of both the women and the neonates. LEVEL OF EVIDENCE: 1 https://t.co/yil8dqWQag

[COVID-19 Literature Surveillance Team @COVID19LST]

UPenn professors discuss 3 studies w/ 39 cases of thrombosis + thrombocytopenia and the AstraZeneca #COVID19 #vaccine. Most were women <50. Clots formed at unusual sites w/ a death rate of 40%. High platelet factor 4 levels were seen in most cases. LOE: 4
https://t.co/N92LbfY0sv

[COVID-19 Literature Surveillance Team @COVID19LST]

No vertical transmission of #SARSCoV2 was seen in 37 pregnant women, but virus was seen in placentas of ½ the SARS-CoV-2-positive 3rd trimester women. Authors think low viral load may not cause harm, but high loads can impair neonatal development. LOE: 4
https://t.co/N92LbfY0sv