We are ready to scale up glycogen analysis using electron microscopy.
By applying a new AI-based image analysis pipeline, workload for 50 samples was reduced from ~600 hours to ~20 hours. This moves us beyond small-scale TEM studies.
Details below 👇
Our sea-level friends at @SyddanskUni provide today's #ArticleinPress, Effect of high-altitude exposure on #skeletal#muscle mitochondrial subcellular distribution, ultrastructure and respiration in sea-level residents (Camilla Tvede Schytz et al.):
https://t.co/2PePKqLJxu
I am thrilled to share one of the first major works from my postdoc in Amsterdam, "Skeletal muscle mitochondrial fragmentation predicts age-associated decline in physical capacity", published online yesterday in @AgingCell https://t.co/mRE5sKcNQy. A thread:
New preprint, the first after my my PhD.
Link to article: https://t.co/EVm0uXiWWx
We investigate how high-altitude exposure affects mitochondrial subcellular distribution, ultrastructure, respiratory control, and intrinsic mitochondrial respiratory capacity.
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How do mitochondria, the cell’s energy-producing organelles, perform competing metabolic processes?
Segregation into distinct populations — one that makes energy-storing ATP molecules and one that does not — could explain it
https://t.co/McNw5KrKC6
Membrane potential stimulates ADP import and ATP export by the mitochondrial ADP/ATP carrier due to its positively charged binding site | Science Advances https://t.co/fxCyINAWMc
Our latest paper on aging is finally out in @ExpPhysiol. This is a real IHC tour de force on muscle morphology, satellite cells, capillaries and innervation status so if you are into that, check it out!
@SebastianEdman@MobergPhD @andyphilp_lab @WiApro
https://t.co/5CWKhGigGC
If supported (the 95% confidence intervals included trivial effects), our results suggest that high-altitude exposure enhance the respiratory efficiency of the mitochondrial network.
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Happy to see that our comprehensive meta-regression, "Effects of Exercise Training on Mitochondrial and Capillary Growth in Human Skeletal Muscle," by @Skattebo_Oyvind, @AlmquistNicki, and myself, is now published in @SportsMedicineJ! 🎉more details soon! https://t.co/tlN9fHDOse