Christina Sparbier

PhD student and Commercialisation & Tech Transfer Intern @PeterMacCC | Cancer Epigenetics & Immunology 👩‍🔬🔬💉 | Cool hobbies: bouldering 🧗🏻‍♀️

[Nature Cell Biology @NatureCellBio]

NEW ONLINE: With whole-genome screens, Dawson, Burr & co identify opposing roles for Menin and KMT2A/B in modulating H3K4me3 versus H3K27me3 at bivalent promoters to regulate gene activation.
PDF: https://t.co/CSEceOOQEH
https://t.co/QqtprNOZ2r

[Mark Dawson @MAF_Dawson]

Very excited to present our latest work from ⁦@CSparbier⁩ ⁦@burr_marian⁩ and others in ⁦@TheDawsonLab⁩. A surprising finding with Menin that may open up new opportunities for Menin inhibitors- Hope you enjoy it. https://t.co/HWos8jQ8wX

[Christina Sparbier @CSparbier]

Our work opens up new therapeutic opportunities for the use of Menin inhibitors to overcome tumour-promoting and immunosuppressive functions of polycomb. (10/10)

[Christina Sparbier @CSparbier]

I’m excited to share my first first-author publication from my PhD showing that targeting Menin tips the balance of KMT2A/B and Polycomb to drive expression of bivalent genes @NatureCellBio https://t.co/7fqw8ulVyO. Huge thanks to @MAF_Dawson @burr_marian @TheDawsonLab. 🧵👇(1/10)

[Christina Sparbier @CSparbier]

Our findings have important implications for cancer therapy- Menin inhibition enhances MHC-I expression and T cell-mediated killing in SCLC and, when combined with EZH2 inhibitors, substantially increases the killing of EZH2 mutant DLBCL cells. (9/10)

[Dane Vassiliadis @DaneVass]

@TheDawsonLab is hiring!!! Applications are now open for a wet-lab scientist to work closely with me on a range of cutting-edge projects at the intersection of #singlecell #epigenetics and #immunooncology! Apply at link below or send me a DM for more info.
https://t.co/VqqBFNIbVH

[Christina Sparbier @CSparbier]

What a fantastic event with such powerful women #WomenInSTEM #biomelbwomen @biomelb

[Christina Sparbier @CSparbier]

Excited to attend the Connecting Women Lunch @biomelb #biomelbwomen

[Christina Sparbier @CSparbier]

I am very excited present my work tomorrow! Please join me online or in person(!!!!) to hear about my work on understanding bivalent gene regulation in cancer. https://t.co/rG1Pjpq6YR
@UMCCR @PeterMacRes @TheDawsonLab @burr_marian

[Collaborative Centre for Genomic Cancer Medicine @GenCancerCentre]

#UMCCRSeminar: Join @CSparbier, PhD student with @TheDawsonLab, for a seminar on using whole-genome functional genetic screens to find new ways to target polycomb function in cancer. @MAF_Dawson @PeterMacRes
REGISTER to attend on Zoom or in-person >> https://t.co/Ttyt8KtXRe

[Christina Sparbier @CSparbier]

Another fantastic conference @GenomeConf. Special thanks for the poster prize! I had such a great time presenting my research.

[Lorne Genome Conference @LorneGenomeConf]

Congratulations to all our presenters for making #lorneGenome such a wonderful meeting.

Special congratulations to our talk and poster prize winners 👏👏👏

[Christina Sparbier @CSparbier]

Just used the 20uL filter tip with my p200 pipette! 😢 It's ALWAYS during a critical experiment. I can't be the only one who has felt this pain.

[Christina Sparbier @CSparbier]

Positions available in the Burr Lab. @burr_marian is a brilliant supervisor and exceptional scientist!

[Mark Dawson @MAF_Dawson]

Thrilled to share this study from @TheDawsonLab. A testament to the remarkable perseverance & dedication of @KatieAFennelland @DaneVass who worked so well with each other and for each each other - just how science should be done! https://t.co/mJroDgwDoT 1/3