Calen P. Ryan 🌊

PhD Research Scientist. Reproduction, Aging, Evolution, & (Epi)genetics🧬Stats and R nerd. Martial Artist. Motorcyclist🏍Outdoorsy⛺️ Aquatec🎧. He/him/eh 🇨🇦

[Calen P. Ryan 🌊 @CalenRyan]

Trying to find evolution schemes depicting women. If you have one or wish to contribute, post here! #sciart #evolution (image: Eduardo Saiz)

[Calen P. Ryan 🌊 @CalenRyan]

@GJasienska Birds will be tipsy!

[Calen P. Ryan 🌊 @CalenRyan]

New work looking at how epigenetic clocks and cell composition derived from Illumina EPICv1 and v2 compare, led by our outstanding colleagues @UBC @koborlab Always thrilled to publish with such a great team!

[Kobor Lab @koborlab]

Ever wondered about compatibility of @illumina #infinium V1 versus V2 #arrays for #epigenetics population studies including #epigenetic age & #risk scores? Check out our newest, courtesy of our wonderful #bioinformatics team and an awesome group of amazing @collaborators - enjoy!

[Anna Medaris @AnnaMedaris]

My latest story for @AARP is live! As a bonus, I got to hang out with my editor IRL at this past weekend's @AHCJ conference in NYC. TY @mkaeberlein @CalenRyan @StevenAustad for your research & insight. https://t.co/Q9D5eGg7Py #aging #longevity #healthwriting #freelance

[Lifespan News @LifespanNews]

🧬What is the link between telomeres and aging, and why does caloric restriction appear to influence them?
A new study sheds some light.
https://t.co/Cv0c5u2yuj
@whastings2012 @Wolf_SarahE @CalenRyan @RacetteSusan @DrLeanneRedman @Danbelsky
#TelomereAttrition #CALERIE #CR

[Calen P. Ryan 🌊 @CalenRyan]

@natalie_matosin @KieranOD_PhD Thank you! Funny though I've seen responses to our work from non-scientists at both extremes.

1. "Obviously unnecessary study! Of course pregnancy and parenthood ages us!"

2. "Obviously wrong. My aunt had 8 kids and lived to 100".

Exactly why we need the science!

[Calen P. Ryan 🌊 @CalenRyan]

@KieranOD_PhD @Danbelsky @koborlab Thanks @KieranOD_PhD! Really fascinating and I think complementary findings to your work!

[Calen P. Ryan 🌊 @CalenRyan]

@JKresovich @PNASNews @koborlab @Danbelsky @ChrisKuzawa Thanks @JKresovich! Yes! We still need to account for studies showing faster bio aging with parity like our NHANES study, and some of the epi data linking parity to CVD, kidney disease, all-cause mortality (at the high end of parity after the j-shaped portion). Much to learn!

[Calen P. Ryan 🌊 @CalenRyan]

Our publication showing that pregnancy is associated with faster epigenetic aging is out now in @PNASNews!

https://t.co/t4JKhpxiwp
@koborlab @Danbelsky @ChrisKuzawa

A thread about the paper below 👇

[Calen P. Ryan 🌊 @CalenRyan]

Stimulating questions and great discussion on our recent paper with @eabrown18 - read more about it in her article with @NatGeo!

[Christine Dell'Amore @cdellamore]

Not news for us moms, but interesting nonetheless! By @eabrown18 for @NatGeo
https://t.co/ezCXdQCQ7M

[Calen P. Ryan 🌊 @CalenRyan]

More broadly, these kinds of studies are highlighting how research in biological aging has often overlooked women and women’s health: we really think more carefully about pregnancy, menstruation, and menopause, when building, testing, and validating measures of biological aging.

[Calen P. Ryan 🌊 @CalenRyan]

We measured biological aging using 6 epigenetic clocks, a family of revolutionary tools for studying aging and predicting health and longevity. You can read more about them in my not too out-of-date review article. https://t.co/PHL3OlFHva

[Calen P. Ryan 🌊 @CalenRyan]

The effects we see are small, and we still don’t know the long-term implications. But this kind of research may one day help us identify who is at the greatest risk and devise ways to support them to minimize any long-term costs of reproduction.