Capillary.io

Specialized software for improved nailfold capillaroscopy powered by artificial intelligence. #capillaroscopy

[Capillary.io @CapillaryIo]

🚀 New updates in https://t.co/guMfko30Jw!

🔍 Better exploration of capillaroscopic findings
📊 Clearer visualization of quantitative metrics
🤖 More intuitive suggested pattern analysis
Try it out & let us know your thoughts!

[Capillary.io @CapillaryIo]

@dr_immuno29 All neural network analysis with https://t.co/daNFerhF6P! 🙂

[Dr.Mukesh , MD , DM @dr_immuno29]

JDM UPDATE 2026: BEYOND CK — LOOK AT THE VESSELS!

Two new 2026 studies reinforce a key concept:

👉 Juvenile dermatomyositis (JDM) is a systemic vasculopathy—and its microvasculature may become a measurable biomarker.

🔬 NAILFOLD CAPILLAROSCOPY
In JDM/overlap myositis:

• Branched capillaries enriched in JDM/OM
• 4/5 TIF1γ+ JDM clustered in the branched phenotype
• Microhaemorrhage density correlated with:
PGA r=0.60
LDH r=0.43
vWF-Ag r=0.51
Neopterin r=0.69

📉 After treatment → ↓ microhaemorrhages + ↑ capillary density

🤖 Automated neural-network analysis may help transform NVC from a descriptive test → quantifiable imaging biomarker.

🧪 BEYOND CK: CXCL10 & GALECTIN-9

A second 2026 study (52 JDM) found 8/16 endothelial mediators elevated.

⭐ CXCL10 → PGA r=0.76
⭐ Galectin-9 → PGA r=0.65

Both also tracked nailfold microvascular injury.

CXCL10, Gal-9, Ang-2 & sTNF-RII differed between NXP2+ and TIF1γ+ JDM, suggesting MSA-specific vascular biology.

📌 2026 takeaway

JDM monitoring may be moving from:

CK alone ➡ phenotype + MSA + endothelial biomarkers + quantitative capillaroscopy

The nailfold may be telling us what is happening in the disease before muscle enzymes tell the whole story.

📚 References
McClellan N, et al. Clin Transl Med. 2026;16:e70789.
DOI: 10.1002/ctm2.70789

Front Immunol. 2026.
DOI: 10.3389/fimmu.2026.1934690

#JDM #JuvenileDermatomyositis #Myositis #PediatricRheumatology #Capillaroscopy #Biomarkers #Rheumatology

[Medscape @Medscape]

Oral vitamin B3 (nicotinamide) at 500 mg twice daily for 14 days improved nailfold videocapillaroscopy (NVC) patterns in around 45% of participants with primary or scleroderma-related Raynaud phenomenon (RP), with increased normal capillaries and reduced abnormal features. Participants with primary RP experienced improvements in RP-related quality of life. https://t.co/HZK9i5mhfD

[Oren Gottfried, MD @OGdukeneurosurg]

What do these fingernail beds show you? A 45-year-old woman reports that the skin on her hands has become tight and shiny, she has increasing acid reflux, and it is becoming harder to open her mouth fully.

[Capillary.io @CapillaryIo]

@Stace_Alexander @ImmunoFever @ISLCPAIS @resiapretorius @amyrochlin @CODA_research Sure, you can find some models in our store: https://t.co/kOJVxITgOd

[Medscape @Medscape]

Long-term follow-up of patients with early Raynaud's phenomenon (RP) over more than 20 years confirms an association between abnormal nailfold capillaries, antinuclear antibodies (ANA), and increased mortality compared with those with neither marker.

"The coexistence of ANA positivity and abnormal nailfold capillaries may identify a subgroup with an underlying systemic biological vulnerability that adversely influences outcomes across a broad range of intercurrent illnesses. Whether this reflects generalized microvascular dysfunction, immune dysregulation, or another systemic process remains to be determined," the authors of the study wrote. https://t.co/VNHstcQuBL

[Capillary.io @CapillaryIo]

@Karin189678 @resiapretorius You can check https://t.co/99v8lCL1X1

[Capillary.io @CapillaryIo]

@ImmunoFever @Lorant661 @Naomi_D_Harvey @BanhamGemma @renesugar @IsabelRamirezRD @dbkell @PutrinoLab @healingfromlc Would need calibration but looking good!
Also the first image has quality warning due to reflections but is almost ok

[Capillary.io @CapillaryIo]

@ImmunoFever @Lorant661 @Naomi_D_Harvey @BanhamGemma @renesugar @IsabelRamirezRD @dbkell @PutrinoLab @healingfromlc Looks acceptable! Though maybe the tool will report magnification too low warning, but still do the analysis. Would need the originals for testing

[Capillary.io @CapillaryIo]

@Naomi_D_Harvey @ImmunoFever @bcgraciatello @NobleRingleader @einfachkaffee Right... you can try taking a picture of a micrometer ruler or similar, to have an approximate calibration source that you can use in our app

[Capillary.io @CapillaryIo]

@ImmunoFever @bcgraciatello @Naomi_D_Harvey @NobleRingleader @einfachkaffee Sure! We have always designed it to work on images from any source as long as capillaries are actually visible. Though calibration for precise metrics can be a challenge for the user with a random device, while on devices with known calibration it's simple

[Daniel Simac @danielsimac]

From the minds behind https://t.co/IiQAZLOtjD with some impressive AI software comes https://t.co/tT3xKa9dAK a great site for #capillaroscopy education. Learn how to, then pick up a capillaroscope from https://t.co/ULrBqzqytc and then get to the AI. I'm currently on step 2/3.

[Capillary.io @CapillaryIo]

@ImmunoFever @einfachkaffee @Naomi_D_Harvey @NobleRingleader Great! Send us an email and we can meet when it works for you 👌

[Capillary.io @CapillaryIo]

@dianeducret Hola! Sí, estamos en Zaragoza, si quiere puede escribirnos un DM y lo intentamos agendar

[Capillary.io @CapillaryIo]

🚀 New updates in https://t.co/guMfko30Jw!

🔍 Better exploration of capillaroscopic findings
📊 Clearer visualization of quantitative metrics
🤖 More intuitive suggested pattern analysis
Try it out & let us know your thoughts!

[Capillary.io @CapillaryIo]

@ImmunoFever @Naomi_D_Harvey @NobleRingleader @einfachkaffee If the image quality is good enough, absolutely! Although higher quality sources remain preferable for clinical use.

Some of the images from @einfachkaffee already look suitable, and we’re continuously improving our models to perform well on suboptimal images too.

[Capillary.io @CapillaryIo]

@ImmunoFever @Naomi_D_Harvey @NobleRingleader @einfachkaffee Hey Michal! Let us know if you need help integrating with our API :)

[Capillary.io @CapillaryIo]

@einfachkaffee @ImmunoFever @Naomi_D_Harvey @NobleRingleader You can try with https://t.co/guMfko30Jw! Let us know if you need any help

[Capillary.io @CapillaryIo]

@joraltron is sharing the latest results from #eular on behalf of the capiAMI group. Congratulations!

[Capillary.io @CapillaryIo]

@joraltron comenta en representación del grupo capiAMI los últimos resultados en @eular_org. Enhorabuena!

[EMEUNET @EMEUNET]

🎥 Meet Jorge Álvarez Troncoso @joraltron, one of the EMEUNET Top 10 Abstract winners at EULAR 2026!
📍 Don’t miss his presentation in London on Thur. 4 June 2026, 8:55 - 9:05, George V Room 3!

#eularEMEUNET #emeunettop10abstracts #EULAR2026 congress