Héloïse Carion

Ph.D. student in the Marraffini lab @RockefellerUniv | Formerly @UCSF @UCBerkeley | NSF GRFP Fellow

[Héloïse Carion @CarionHeloise]

It's up! Super excited to share our work highlighting the utility of 🔥phage accessory genes🔥 as a tool to elucidate the many layers of phage-host competition.

"If you want to know what the host is doing, just ask its virus" - Sukrit, probably

[Joe Bondy-Denomy @joeBondyDenomy]

Years ago, we wrote a proposal about using phage anti-defense genes to discover new defense systems. The idea was to take advantage of anti-defense gene clustering (islands) to ask what the neighbors of known anti-RM/CRISPR genes are inhibiting. 1/5
https://t.co/FTIzsySViW

[Rockefeller University @RockefellerUniv]

Grad student @CarionHeloise of the Marraffini lab was interviewed by @MolecularCell about her latest paper on the activation of bacterial programmed cell death by phage inhibitors of host immunity. Check it out here:
https://t.co/Q5w4uwMqO0

[Ben Adler @ben_a_adler]

It is finally out!

Muntathar Al-Shimary, Doudna Lab, @bradyfcress and I present a gene knockdown tool that works in diverse phages: CRISPRi through antisense RNA Targeting (CRISPRi-ART)!

Check out the final paper in @NatureMicrobiol
https://t.co/DJkBM5fhPL

[Héloïse Carion @CarionHeloise]

phages are spooky

[Joe Bondy-Denomy @joeBondyDenomy]

Did you know that bacteria remember their past for many generations? In this new preprint from us (@VillaniAlexis and Senen Mendoza) and Banin lab (@ShmidovE ), we reveal the "how?" and "why?" underlying a long-standing mystery in bacterial memory. https://t.co/zFc8PDLqTu

[Héloïse Carion @CarionHeloise]

@ErinHuiting @MDMlab_Paris huge fan. congrats Erin!!!

[MDMLab @MDMlab_Paris]

Excited to introduce AntiDefenseFinder - a free, open source tool that detects anti-defense systems in any genomic sequence. Available here to toggle on/off: https://t.co/2Z08fGyQLD. Read below for our insights into the >47K detectable systems📈 https://t.co/DQ77gTjlb2

[Yuping Li @liyuping927]

I am thrilled to start my lab as an assistant professor @biozentrum & @NCCR_AntiResist of @UniBasel_en this fall. I will continue my research interest in bacteria & jumbophage interactions. Equally thrilled to be closer to our families after 10+ years.

[Amer Azim Hossain @amer_hossai1]

Excited to share my latest work from the @MarraffiniLab, in collaboration with @PhoebeARice, now online @Nature!!

https://t.co/95cscM2MJr

We report the discovery of DNA glycosylases that provide anti-phage defense in bacteria!

A thread 🧵: 1/

[Joe Bondy-Denomy @joeBondyDenomy]

New preprint from the lab, led by outstanding student Claire Kokontis! (@CKokontis) In this work Claire et al. discover Imp1-Imp6, phage proteins required for the selective import of proteins into the jumbo phage nucleus! Imp1 (below) is the special one.
https://t.co/dtmUfpV8uk

[Ben Adler @ben_a_adler]

Hachiman is hot off the (preprint) presses! @owen_t_tuck and I in @doudna_lab present a model for how this broad-activity defense system recognizes genome integrity, a core feature of phage infection.

Check out the preprint and Owen's thread for the news:

[Aude Bernheim @AudeBer]

Yesterday, i had the honor of becoming part of the first Scientific Council for the French President, among a group of 12 incredible scientists.
A tad far from my 🦠, but hopefully will help a bit in fostering the role of science & knowledge in our society and democracy.

[Héloïse Carion @CarionHeloise]

@jina_leemon @Emy_nim @ucsdbiosciences @HHMINEWS wooooohoooo I love big phages and I cannot lie

[Ben Adler @ben_a_adler]

I’m really excited to share our new pre-print “Genome-wide Characterization of Diverse Bacteriophages Enabled by RNA-Binding CRISPRi”, with co-first author Muntathar Al-Shimary @doudna_lab and the newly-minted @bradyfcress lab!
https://t.co/KWg8FAUhLJ
🧵🧵
1/

[MDMLab @MDMlab_Paris]

Happy to share our new preprint!
We used viperins🐍, to understand the conservation and diversification of immune genes across domains of life.

A deep dive in the evolutionary history of immune genes shared by prokaryotes and eukaryotes!
https://t.co/6iKcEEbfee

[Tim Stearns @StearnsLab]

Class picture time for incoming @RockefellerUniv grad student class!

[Héloïse Carion @CarionHeloise]

@vivek_mutalik @carimfraiche @rishihs @ben_a_adler this is a powerful squad

[Erin Huiting @ErinHuiting]

The increasing discovery of anti-phage bacterial immune systems (>100 in 5 years!) means an increasing diversity of phage activators. Here, @joeBondyDenomy and I review phage proteins as a prominent ‘pattern of pathogenesis’ and how they activate immunity. https://t.co/UNrxrWIG7l

[Héloïse Carion @CarionHeloise]

@joeBondyDenomy @mtcjh @Nicole_D_Marino scientific sorority squat 💯

[Matt @mtcjh]

It's finally out! 🚀 Before doing a genome-wide screen in P. aeruginosa looking for immune systems, look in these two conserved anti-phage hotspots we named cDHS1 and cDHS2.
https://t.co/52evYuNq1E

Congrats to all the coauthors!
@joeBondyDenomy @ErinHuiting @ARDavidson_UofT

[Joe Bondy-Denomy @joeBondyDenomy]

BIG Congratulations to @Nicole_D_Marino who just signed her offer letter at UPenn @PennVet Pathobiology Departmant to start her own lab! The Marino lab opens Jan 1, 2024 focusing on new discoveries at the interface of phage and host immunity! s/o to Chair @BrodskyIgor