AT1 autoantibodies also increased levels of neuroinflammation markers, which was inhibited by the AT1 antagonist candesartan; The autoantibodies were also found in PD cerebrospinal fluid; Further support for repurposing angiotensin type-1 receptor blockers for #Parkinsons?
Interesting: @LabandeiraL & colleagues report that angiotensin type-1 receptor & angiotensin-converting enzyme 2 (ACE2) serum autoantibodies were higher in 117 individuals with #Parkinsons (vs 106 controls); AT1 autoantibodies ⬆ neurodegeneration in vitro
https://t.co/IgKyPWfkMD