The scientific editors of Cell Host & Microbe, a Cell Press journal, bring you the latest information and insights from the forefront of host-microbe research.
Soil microbial diversity associates with lower prevalence of human bacterial pathogens across global soils. A study by @Prof_Braj_Singh & colleagues in @Cellhostmicrobe#ASMicrobe https://t.co/g9wGf8GE8Y
Weekend revisit! Engineered microbes improve Parkinson’s treatment
Gut microbe bioengineered to produce L-DOPA in non-pulsatile manner. Biotherapeutic reduces drug fluctuations causing symptoms & improves motor performance in multiple animal models
https://t.co/c0gpDVH8OB
SCFAs mediate C. albicans colonization resistance
Microbiota-derived SCFAs inhibit C. albicans GI colonization via direct fungal inhibition (acidification, impaired glucose uptake & metabolic arrest) & reshaping microbiota for colonization resistance
https://t.co/nNJKJSMKBL
Microbiota-derived valeric acid blunts C. parapsilosis
Valeric acid levels inversely correlate w/Candida burden in allo-HCT patients. VA induces loss of intracellular C. parapsilosis pH homeostasis & VA derivatives suppress C. parapsilosis growth in vivo
https://t.co/Tl9nhTIKKa
Uric acid drives obesity by modulating gut ecology
Uric acid suppresses L. johnsonii, which⬇️microbial phenyllactic acid, a suppressor of PPARα-mediated lipid absorption. Ablating UA regulator TIP60 restores L. johnsonii-PLA, offering therapeutic strategy
https://t.co/dwEoJOvmRj
Bacteria vs phage: new layers in NAD+ centric arms race
aRES is bacterial protein that blocks phage infection by cleaving NAD+ into ADPR-1P & nicotinamide. Phages counter using NAD+ reconstitution pathway w/ADPR-1P & nicotinamide as substrates
https://t.co/xXOHaUzGGG
Oat-β-glucan boosts anti-PD-1 w/the help of microbes
In CRC, oat-β-glucan enhances anti-PD-1 efficacy via⬆️F. prausnitzii & production of butyrate& IPA, which enhance CD8 T cell & DC functions. In human trial, oat-β-glucan ⬆️F. prausnitzii, butyrate & IPA
https://t.co/s4gBZmf0Tv
Can microbiota mitigate antipsychotic-induced cognitive impairment?
Antipsychotics deplete Cyanobacteria & ergothioneine, leading to cognitive impairment but ergothioneine ⬇️ cognitive deficits by ⬇️ hippocampal oxidative stress
@cellhostmicrobe
https://t.co/Xy3iwtsemD
Timely revisit: Accelerating mammalian filovirus research w/receptor binding blueprints
Preview of work predicting susceptible host species & guiding filovirus and Ebola virus surveillance, yielding blueprints for research and prevention
https://t.co/gR13zHHQMq
Timely paper revisit: Blueprint of filovirus-receptor binding
Binding assays & machine learning uncover rules of filovirus-receptor binding, predict receptor-binding strength & ID bats w/potential as Ebola virus hosts
https://t.co/wJIzHBwfKw
Fueling C. albicans & colitis
· C. tenuissimum alleviates colitis by inhibiting C. albicans via ornithine competition
· C. albicans escapes by exploiting threonine
· B. fragilis supports C. albicans via threonine,but threonine-restricted diet limits escape
https://t.co/wnFRCZCr5k
⚡️ Years after polyp removal, women’s gut microbes still show patterns linked to colorectal cancer - suggesting hidden risks may persist long-term. https://t.co/wjWf0LRFWj #ColorectalCancer#GutHealth#Microbiome 🧬 @cellhostmicrobe
The ocean is home to the largest microbiome on Earth, but much of it remains unexplored.
Join the webinar, Marine microbiology in a changing climate, June 23 at 10 a.m. ET to explore how ocean microbes shape planetary health and climate resilience.
https://t.co/0MAGLor3wc
Working on some exciting #microbiology research that you’d like to share with the community?
Book a virtual meeting with @cellhostmicrobe editor Amanda Monahan to discuss the publishing process https://t.co/VgeF7TcjNz #ASMicrobe
Adenomas leave lasting microbiome imprint
Microbial/metabolic alterations detectable in patients >10 yr after adenoma resection that partially resemble those in colorectal cancer, suggesting sustained host-microbiome axis along adenoma-carcinoma continuum
https://t.co/xq6b092FpR
Epigenetic phase variation in microbiome
Epigenetic phase variation is prevalent in human gut microbiome & linked w/ fluctuating environments. In Akkermansia, an ePV upregulates gene expression, enhancing adaptation to antibiotics via bet-hedging
https://t.co/Waazf6W2tK
Weekend read! Mycorrhizal networks facilitate resistance
Transfer of jasmonic acid via mycorrhizal networks from B.cinerea-infected to healthy plants causes shifts in root exudates to recruit disease-suppressive bacteria to rhizosphere, yielding resistance
https://t.co/PeZcprF1wu
SPART, a pan-orthoflavivirus restriction factor
CRISPR activation screen IDs SPART as broadly restricting orthoflaviviruses by altering localization of ITCH. ITCH mediates capsid ubiquitination, triggering its degradation & release of viral RNA
https://t.co/NVhwc4G0TL
Is there a role of microbial regulation of serotonin as a boost for drug delivery?
@UCCpsychiatry & @jfcryan explain the relevance of a new paper in the field
@cellhostmicrobe
https://t.co/QQnh1LMlyC