Cell Host & Microbe

The scientific editors of Cell Host & Microbe, a Cell Press journal, bring you the latest information and insights from the forefront of host-microbe research.

[Cell Host & Microbe @cellhostmicrobe]

Focus Issue on The Virome!
Forums, Perspectives and Reviews examining the latest insights and open questions.
https://t.co/ibKjXf89My

[Cell Press @CellPressNews]

Soil microbial diversity associates with lower prevalence of human bacterial pathogens across global soils. A study by @Prof_Braj_Singh & colleagues in @Cellhostmicrobe #ASMicrobe https://t.co/g9wGf8GE8Y

[Cell Host & Microbe @cellhostmicrobe]

Weekend revisit! Engineered microbes improve Parkinson’s treatment

Gut microbe bioengineered to produce L-DOPA in non-pulsatile manner. Biotherapeutic reduces drug fluctuations causing symptoms & improves motor performance in multiple animal models
https://t.co/c0gpDVH8OB

[Cell Host & Microbe @cellhostmicrobe]

SCFAs mediate C. albicans colonization resistance

Microbiota-derived SCFAs inhibit C. albicans GI colonization via direct fungal inhibition (acidification, impaired glucose uptake & metabolic arrest) & reshaping microbiota for colonization resistance
https://t.co/nNJKJSMKBL

[Cell Host & Microbe @cellhostmicrobe]

Microbiota-derived valeric acid blunts C. parapsilosis

Valeric acid levels inversely correlate w/Candida burden in allo-HCT patients. VA induces loss of intracellular C. parapsilosis pH homeostasis & VA derivatives suppress C. parapsilosis growth in vivo
https://t.co/Tl9nhTIKKa

[Cell Host & Microbe @cellhostmicrobe]

Uric acid drives obesity by modulating gut ecology

Uric acid suppresses L. johnsonii, which⬇️microbial phenyllactic acid, a suppressor of PPARα-mediated lipid absorption. Ablating UA regulator TIP60 restores L. johnsonii-PLA, offering therapeutic strategy
https://t.co/dwEoJOvmRj

[Cell Host & Microbe @cellhostmicrobe]

Bacteria vs phage: new layers in NAD+ centric arms race

aRES is bacterial protein that blocks phage infection by cleaving NAD+ into ADPR-1P & nicotinamide. Phages counter using NAD+ reconstitution pathway w/ADPR-1P & nicotinamide as substrates
https://t.co/xXOHaUzGGG

[Cell Host & Microbe @cellhostmicrobe]

Oat-β-glucan boosts anti-PD-1 w/the help of microbes

In CRC, oat-β-glucan enhances anti-PD-1 efficacy via⬆️F. prausnitzii & production of butyrate& IPA, which enhance CD8 T cell & DC functions. In human trial, oat-β-glucan ⬆️F. prausnitzii, butyrate & IPA
https://t.co/s4gBZmf0Tv

[GutMicrobiota Health @GMFHx]

Can microbiota mitigate antipsychotic-induced cognitive impairment?

Antipsychotics deplete Cyanobacteria & ergothioneine, leading to cognitive impairment but ergothioneine ⬇️ cognitive deficits by ⬇️ hippocampal oxidative stress

@cellhostmicrobe 

https://t.co/Xy3iwtsemD

[Cell Host & Microbe @cellhostmicrobe]

Timely revisit: Accelerating mammalian filovirus research w/receptor binding blueprints

Preview of work predicting susceptible host species & guiding filovirus and Ebola virus surveillance, yielding blueprints for research and prevention
https://t.co/gR13zHHQMq

[Cell Host & Microbe @cellhostmicrobe]

Timely paper revisit: Blueprint of filovirus-receptor binding

Binding assays & machine learning uncover rules of filovirus-receptor binding, predict receptor-binding strength & ID bats w/potential as Ebola virus hosts
https://t.co/wJIzHBwfKw

[Cell Host & Microbe @cellhostmicrobe]

Fueling C. albicans & colitis
· C. tenuissimum alleviates colitis by inhibiting C. albicans via ornithine competition
· C. albicans escapes by exploiting threonine
· B. fragilis supports C. albicans via threonine,but threonine-restricted diet limits escape
https://t.co/wnFRCZCr5k

[News Medical @NewsMedical]

⚡️ Years after polyp removal, women’s gut microbes still show patterns linked to colorectal cancer - suggesting hidden risks may persist long-term. https://t.co/wjWf0LRFWj #ColorectalCancer #GutHealth #Microbiome 🧬 @cellhostmicrobe

[Cell Host & Microbe @cellhostmicrobe]

The ocean is home to the largest microbiome on Earth, but much of it remains unexplored.
Join the webinar, Marine microbiology in a changing climate, June 23 at 10 a.m. ET to explore how ocean microbes shape planetary health and climate resilience.
https://t.co/0MAGLor3wc

[Cell Press @CellPressNews]

Working on some exciting #microbiology research that you’d like to share with the community?
Book a virtual meeting with @cellhostmicrobe editor Amanda Monahan to discuss the publishing process https://t.co/VgeF7TcjNz #ASMicrobe

[Cell Host & Microbe @cellhostmicrobe]

Adenomas leave lasting microbiome imprint

Microbial/metabolic alterations detectable in patients >10 yr after adenoma resection that partially resemble those in colorectal cancer, suggesting sustained host-microbiome axis along adenoma-carcinoma continuum
https://t.co/xq6b092FpR

[Cell Host & Microbe @cellhostmicrobe]

Epigenetic phase variation in microbiome

Epigenetic phase variation is prevalent in human gut microbiome & linked w/ fluctuating environments. In Akkermansia, an ePV upregulates gene expression, enhancing adaptation to antibiotics via bet-hedging
https://t.co/Waazf6W2tK

[Cell Host & Microbe @cellhostmicrobe]

Weekend read! Mycorrhizal networks facilitate resistance
Transfer of jasmonic acid via mycorrhizal networks from B.cinerea-infected to healthy plants causes shifts in root exudates to recruit disease-suppressive bacteria to rhizosphere, yielding resistance
https://t.co/PeZcprF1wu

[Cell Host & Microbe @cellhostmicrobe]

SPART, a pan-orthoflavivirus restriction factor

CRISPR activation screen IDs SPART as broadly restricting orthoflaviviruses by altering localization of ITCH. ITCH mediates capsid ubiquitination, triggering its degradation & release of viral RNA
https://t.co/NVhwc4G0TL

[GutMicrobiota Health @GMFHx]

Is there a role of microbial regulation of serotonin as a boost for drug delivery?

@UCCpsychiatry & @jfcryan explain the relevance of a new paper in the field 

@cellhostmicrobe 

https://t.co/QQnh1LMlyC

[Cell Host & Microbe @cellhostmicrobe]

Fungal pathobiont boosts Streptococcus

Fungal colonization primes group B strep pathogenic potential in vaginal tract via contact-dependent nutrient sharing. Interactions w/C. albicans promote bacterial adhesion & facilitate antibiotic evasion
https://t.co/qyuuPLNEJs