Cell Host & Microbe

The scientific editors of Cell Host & Microbe, a Cell Press journal, bring you the latest information and insights from the forefront of host-microbe research.

[Cell Host & Microbe @cellhostmicrobe]

Our October issue is now live!
Get ‘wrapped’ up in this month’s exciting microbiology.

https://t.co/ibKjXf8HC6

[Cell Host & Microbe @cellhostmicrobe]

Weekend revisit!
VIBRANT: Phase 1 trial of multi-strain L. crispatus for BV

Women w/bacterial vaginosis receiving multi-strain vaginal L. crispatus live biotherapeutic 3–7d post antibiotics showed vaginal colonization up to 12 wks, reducing recurrent BV
https://t.co/rV0bF8Xqex

[Cell Host & Microbe @cellhostmicrobe]

Microbial-epigenetic-circadian axis orchestrates nutrient absorption

Microbial inositol phosphates translate feeding time into diurnal rhythms via HDAC3, activating nutrient absorption--promoting growth during undernutrition & obesity upon overnutrition
https://t.co/nfKmSkI7Ho

[Cell Host & Microbe @cellhostmicrobe]

Phage small RNA mimics chimeric guide to inhibit CRISPR-Cas9

rAcrIIA1 is phage-encoded chimeric crRNA-tracrRNA mimic that blocks Cas9 guide loading & DNA interference. This reprogrammable RNA guide enables genome editing, gene silencing & diagnostics
https://t.co/IiodZ8j6n3

[Cell Host & Microbe @cellhostmicrobe]

Discovering phage defense systems through modularity networks

Modular organization of bacterial immune systems is used to ID phage defense systems. 3 systems in P. aeruginosa reveal strategies against jumbo phages & RM-like system w/additional components
https://t.co/Wfd4LlCkbW

[Cell Host & Microbe @cellhostmicrobe]

Akkermansia enhances anti-PD-1 efficacy

A. muciniphila attenuates macrophage efferocytosis to overcome PD-1 resistance in microsatellite-stable colorectal cancer (MSS CRC). Phase 1 trial supports microbiome modulation to improve immunotherapy in MSS CRC
https://t.co/tIQpBROPpl

[Cell Host & Microbe @cellhostmicrobe]

Akkermansia protects against endometritis

A.muciniphila protects against endometritis by driving tyrosol production, which reaches uterus & suppresses inflammation. Work reveals metabolite-mediated gut-uterus axis linking microbiota to reproductive health
https://t.co/ncSQPi0lyj

[Cell Host & Microbe @cellhostmicrobe]

Gemella morbillorum promotes CRC

Colonization of the colon by G. morbillorum increases intestinal permeability, enables epithelial cell invasion, reshapes host lipid metabolism & triggers DNA damage, collectively accelerating colorectal tumorigenesis
https://t.co/kpUdBtriYN

[Cell Host & Microbe @cellhostmicrobe]

C. auris turns skin immunity to its advantage

Preview of @ScienceMagazine paper showing C. aurisoccupies hair follicles & exposes chitin, triggering IFN responses that remodel follicular keratinocytes to promote fungal persistence
https://t.co/c4Sm55huge

[Cell Host & Microbe @cellhostmicrobe]

Microbial chromatin remodeler drives cancer progression

S.anginosus promotes gastric immune evasion via EVs delivering bacterial chromatin remodeler to host cells, co-opting TEAD1 to⬆️ZDHHC11 & stabilize PD-L1. Targeting axis potentiates anti-PD-1 therapy
https://t.co/n9MEHYI3UU

[Cell Press @CellPressNews]

"Akkermansia muciniphila protects against endometritis through a tyrosol-mediated gut–uterus axis."

Learn more in Cell Host & Microbe: https://t.co/4x3COuzlRn

Jiuxi Liu, Xufeng Xie, and Yongguo Cao
@cellhostmicrobe

[Cell Host & Microbe @cellhostmicrobe]

Preview: When microbial biofilms build kidney stones

C. glucuronolyticum-like bacteria are urinary pathobionts that promote CaOx crystallization via (1) degradcrystallization inhibitor hippuric acid & (2) biofilm-mediated crystal aggregation
https://t.co/65F4Axy0FW

[Cell Host & Microbe @cellhostmicrobe]

Bacteria promote kidney stones

C. glucuronolyticum-like bacteria enriched in urine of calcium oxalate stone patients & promote CaOx crystallization via hippuric acid degradation & biofilm formation. Hippuric acid prevents bacteria-driven crystallization
https://t.co/1k8s6GMfq8

[Cell Host & Microbe @cellhostmicrobe]

Protein landscape of chromatin domains in Plasmodium

Resource provides comprehensive characterization of chromatin-associated proteins in P. falciparum, revealing insights into parasite gene regulation, transmission & cell cycle control
https://t.co/0V2p8fhrVA

[Cell Host & Microbe @cellhostmicrobe]

Dual sensing activates antiviral reverse transcriptase for membrane targeting

Phage DNA binding proteins or dGTP activate DRT2 to synthesize repetitive neo gene by rolling-circle reverse transcription. Neo depolarizes bacterial membranes & induces death
https://t.co/2cjwJ8XKvk

[Cell Host & Microbe @cellhostmicrobe]

Microbial signal rewires the adipose-ovary dialogue

Preview of work showing gut microbial metabolite reprograms adipose ceramide metabolism to influence ovarian function. Reveals how inter-organ communication couples metabolic & ovarian dimensions of PCOS
https://t.co/wnMAqIaMli

[Cell Host & Microbe @cellhostmicrobe]

Microbial IAM alleviates PCOS

C. aerofaciens & metabolite indole-3-acetamide (IAM) mitigate polycystic ovary syndrome pathology via activating adipose HIF-2α-ceramide signaling. Probiotic strain producing IAM shows therapeutic efficacy in mouse PCOS model
https://t.co/aEg0DmDF47

[Cell Host & Microbe @cellhostmicrobe]

Rewiring tryptophan metabolism for cancer immunotherapy

Oral nanoplatform releases tryptophan & metabolism inhibitor. Redirects tryptophan toward immunostimulatory microbial indole pathway, blocks immunosuppressive kynurenine & elicits antitumor immunity
https://t.co/j0ETCYHxDn

[Cell Host & Microbe @cellhostmicrobe]

Mutant KRAS favors a microbe that signals back

Preview of work examining interplay between tumor genetics & microbiome in CRC--showing mutant KRAS favors B. acidifaciens, which signals back through a SusF-ARHGEF2 axis to reinforce RAS-MAPK signaling
https://t.co/cU7ePLpzef

[Cell Host & Microbe @cellhostmicrobe]

Featured Article: KRAS rewires tumor microbiome

Mutant KRAS reshapes intratumoral microbiome, enriching B. acidifaciens, whose SusF protein stabilizes ARHGEF2 to amplify KRAS–RAF–MEK–ERK signaling & tumorigenesis. Targeting SusF or ARHGEF2 blocked effects
https://t.co/y562bK3MTY

[Cell Host & Microbe @cellhostmicrobe]

Encrypting the message: Bacterium turns host RNA into a target

Preview of new work identifying bacterial effector from Legionella pneumophila that modifies not host proteins but messenger ribonucleic acid (mRNA) to dampen the host inflammatory response
https://t.co/SKFvHKJMux