Seng Chan You

Assist Prof at Dept of Biomedical Systems Informatics, Yonsei Univ College of Medicine

[· @lIIlIlIlIIIlIll]

Just curled up with a warm drink and my favorite playlist on this lazy weekend afternoon—no plans, just cozy vibes

[Suya @boracat]

Hey neighbors! Just dropped extra homemade chocolate chip cookies on the front porch of 4B—help yourselves anytime , and shout if you need anything small this week!，

[english25 @english2511]

Sunday night pizza + board games with my favorite humans — the messy, loud, perfect kind of family night

[Seng Chan You @ChanDrYou]

https://t.co/hmsUcxV5tv

[Seng Chan You @ChanDrYou]

New paper in @JAMIAOpen: THESEUS introduces an AI agent that automates executable Strategus R coding from natural language study designs. The AI study agent achieves up to 95-97% accuracy in replicating published protocols. Agentic AI meets data standards.

[Seng Chan You @ChanDrYou]

https://t.co/WvUVYV3Ss4

[Seng Chan You @ChanDrYou]

New paper in J Biomed Inform: ARKE maps messy local radiology procedure names to the LOINC/RSNA Playbook.
The LLM never generates codes — it only parses attributes and selects from ontology-validated candidates. Ontologies are what make LLMs safe for clinical pipelines.

[Seng Chan You @ChanDrYou]

Paper link: https://t.co/PaQsVmAwmo

[Seng Chan You @ChanDrYou]

Africa bears 25% of global disease burden — yet only 0.6% of RCTs in top CV journals include African sites.
I interviewed Dr. Bamba Gaye for @JACCJournals on why this gap matters scientifically, not just ethically.
"Evidence cannot be truly global if Africa is missing."
#JACC

[Seng Chan You @ChanDrYou]

Full interview: https://t.co/w9vRM4R7HU

[Seng Chan You @ChanDrYou]

@MitsuakiSawano @JACCJournals Thank you for leading this. Kudos!

[Mitsuaki Sawano, MD, PhD, FACC @MitsuakiSawano]

Proud to contribute to the 2025 ACS Guideline Commentary – Asian Perspective, published in @JACCJournals.
📖 Full article: https://t.co/vceDzhDdrf

In this collaborative piece with colleagues across the region, we explore how the new U.S. guidelines for acute coronary syndromes translate into the diverse clinical realities of East and South Asia.

🔑 Key themes:
1. Antithrombotic therapy varies widely—drug access, dosing, and duration differ across countries.
2. Lipid management is aggressive in South Asia (<30 mg/dL LDL-C targets), but high-cost therapies remain out of reach for many.
3. Revascularization strategies reflect infrastructure gaps—ranging from advanced PCI with imaging to fibrinolysis in rural areas.
4. Mechanical circulatory support access is unequal, with reliance on IABP in most settings and limited use of advanced devices.

🌏 The takeaway:
Guidelines are essential but context matters. From aging populations to SES disparities, ACS care in Asia faces unique barriers that demand local adaptation, investment in regional data, and stronger implementation pathways.

Grateful to the editors and co-authors who made this important conversation possible😊

@yuan_lu1 @khurramn1 @denniskomd @SengChanYou1 @DrNathanWong
@JACCJournals @ACCinTouch
#Cardiology #ACSGuidelines #GlobalHealth #JACCAsia #CVOutcomes #AsiaHealth

[Seng Chan You @ChanDrYou]

"Integrating Local Vocabulary into OMOP CDM: A Step-by-Step Tutorial" is now on medRxiv (https://t.co/im2dlguTS9)
We share a practical guide—using Korean EDI codes as an example—to help integrate local vocabularies into the OHDSI ecosystem. #OHDSI

[Seng Chan You @ChanDrYou]

🚨The first New preprint on medRxiv!
We present Y-KNOT, the first bilingual, on-premise LLM agent integrated with EHR for clinical drafting in Korea.
📄 https://t.co/V0kudDhCNg
#LLM #FHIR

[Seng Chan You @ChanDrYou]

@MitsuakiSawano @TheLancetInfDis Congrats!! @MitsuakiSawano So interesting!

[Seng Chan You @ChanDrYou]

What is LOVE? by TWICE @ACC.25

[Seng Chan You @ChanDrYou]

🚨 P2Y12 Pretreatment in NSTE-ACS 🚨
Sim-pub in JACC with #AHA:
1️⃣ Use decreasing, but unrelated to trials/guidelines.
2️⃣ High variability by region &amp; provider.
3️⃣ Linked to longer stays for CABG patients.

🎥 Interview with Dr. Ueyama: https://t.co/jJue69XxsX
#JACC

[OHDSI @OHDSI]

The @JACCJournals collaboration w/ OHDSI opens incredible potential for the community to both publish global #RWE and educate on best practices in observational research. Thank you to @hmkyale, @SengChanYou1, Yuan Lu, @nicolepratt_ &amp; @suchard_group on a great #OHDSI2024 panel!

[Seng Chan You @ChanDrYou]

@prieto_alhambra Then, were did they go?

[Seng Chan You @ChanDrYou]

@prieto_alhambra @JAMANetworkOpen @OPTIMA_oncology @Danielle_Newby @ndorms @UniofOxford Great job, many congrats!