Sarit Cohen Kedar

[iris dotan @Iris_Dotan]

So relevant @RandyLongman @IlievLab @HelmsleyTrust !#fungal recognition & #phagocytosis by #IEC➡️ capability may affect #intestinal #homeostasis & #IBD! @CohenKedar @GastroRMC
https://t.co/VQJmnJ4oj5

[Sarit Cohen Kedar @CohenKedar]

@PLapaquette @tandfonline @CFATG Very interesting!

[Sarit Cohen Kedar @CohenKedar]

6/6 We suggest a mechanism for mucosal sampling of commensal luminal microorganisms and a potential function of IECs as non-professional antigen presenting cells, drawing a role for epithelial participation in mucosal homeostasis and inflammation.

[Sarit Cohen Kedar @CohenKedar]

1/6 Excited to introduce a new paper from @Iris_Dotan lab where we show a novel mode of mucosal interaction with commensals. We demonstrate the uptake of fungal particles by human intestinal epithelial cells via Dectin-1 and LC3-associated #phagocytosis https://t.co/VseYLiKWi5

[Sarit Cohen Kedar @CohenKedar]

5/6 We show LC3-associated phagocytosis of C. albicans yeast and hyphea by human intestinal organoids, and their degradation in the lysosomes.

[Frontiers - Immunology @FrontImmunol]

New Research: Human intestinal epithelial cells can internalize luminal fungi via LC3-associated phagocytosis: Background

Intestinal epithelial cells (IECs) are the first to encounter luminal microorganisms and actively participate in… https://t.co/jy3pP4Hava #immunology

[bioRxiv Immunology @biorxiv_immuno]

Human intestinal epithelial cells can internalize luminal fungi via LC3-associated phagocytosis https://t.co/vmFmF95k2n #biorxiv_immuno

[Sarit Cohen Kedar @CohenKedar]

@Iris_Dotan @MicroMindy @GastroRMC Indeed human 2D organoids open multiple experimental settings to study the epithelial- microbiome interactions. Having a bank of defined patient-derived organoids, will surely give us in RMC, interesting data in the near future.

[iris dotan @Iris_Dotan]

@MicroMindy Human #epithelial cells #phagocytosis of #glycans #fungi in #gut homeostasis ( and implications for #IBD?..)
@CohenKedar @GastroRMC #FluorescenceFriday