Colette Kelly

PhD student at University of Liverpool 🧠🔬

[Tony @purbrooktony]

These are the dogs the Met police murdered. I'll let you make your own minds up.

[Ali Yusaf @aliyusaf]

What’s the favourite drink in Liverpool?

7-up.

@7UP #LiverpoolFC #ManchesterUnited

[DEESIDE.com @DeesideDotCom]

Flintshire Council has voted in favour of adopting its Local Development Plan, despite strong opposition from Hawarden councillors - https://t.co/KfY65n2Kv3

[Colette Kelly @ColetteKellyyy]

My first ever PhD publication is out! 👏😊 for anyone interested in comparison of drug response between 𝘪𝘯 𝘷𝘪𝘷𝘰 and 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 gut systems 👍 the link is below!

[TransQST project @transqst]

We are happy to announce that a new TransQST article has been published in Archives of Toxicology: https://t.co/ayqr5KTAjN

[Colette Kelly @ColetteKellyyy]

heartbroken doesn't begin to cover it.
sleep tight roly bear 🧡 we will miss you

[Michael Jones @100PercentMikey]

People are comparing this to BLM, the movement with the aim of stopping police brutally and killings of African Americans by law enforcement. This MAGA mob is storming the Capitol building because they lost the election. Get your fucking heads checked.

[Liverpool City Council @lpoolcouncil]

Everyone who lives and works in #Liverpool can now get a #Covid19 test... even if you don’t have symptoms.

Book a test: https://t.co/OaLkRKnqUX

#LetsGetTested Liverpool - do it for yourself, do it for your friends and family, do it for your city.

[Ryanair @Ryanair]

the look of a man who might not have access to Air Force One in the future and will have to fly commercial

don't worry Eric, we have €9.99 fares next time you're in Europe

#Election2020

[Colette Kelly @ColetteKellyyy]

22 miles completed! 🏊‍♀️🏆 My fundraising page will stay open until the end of the month and I will still be swimming to add to the total 👍 any donations to Diabetes UK would be greatly appreciated! https://t.co/RTWdUw11rE

[Colette Kelly @ColetteKellyyy]

I’m taking part in the Swim22 challenge - to swim 22 miles, the length of the English Channel, in 12 weeks, in support of Diabetes UK. The challenge doesn’t start til 22nd Feb but my page is open now if you would like to donate 😊 https://t.co/lA2teKMoUh

[Colette Kelly @ColetteKellyyy]

11 miles down, 11 to go! 🏊‍♀️ click the link if you would like to donate to my Swim22 Challenge and support Diabetes UK!https://t.co/lA2teKMoUh

[Bunsen, Beaker, Bernoulli & Brix @bunsenbernerbmd]

1600: DISEASE IS EVERYWHERE!
Science: we can cut ya open and wear spoooky costumes. Lots ya goin die.

1918- DISEASE IS EVERYWHERE HELP
Science: don’t gather. Lots ya goin die

2020- COVID! HALP!
Science: we might have a vaccine in a year- wear a mask
2020- My freedoms though

[Colette Kelly @ColetteKellyyy]

@DrBethanyWPsych @lancspsychres @LancasterUni 👏👏👏👏👏

[IndependentLiverpool @IndpndtLiv]

Good luck to everyone opening tomorrow. Here’s a few words for those planning on venturing out. The main message is to be kind, patient and stay safe ❤️

[Colette Kelly @ColetteKellyyy]

@BethanyWPsych smashing out papers over here 👏

[Colette Kelly @ColetteKellyyy]

@RoyGoodacre @FHLSPGR @LivUniEngageHLS @LivUniISMIB Thank you @RoyGoodacre! I have not investigated any microbial biotransformations, so far I have been looking at the toxicity effects solely on the intestinal epithelial cells, however I do respect that gut microflora will play a part in drug metabolism!

[Colette Kelly @ColetteKellyyy]

Taking part in the virtual #HLSPosterDay2020!
My poster is titled:
Modelling Intestinal Toxicity using 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 3D gut cultures
#HLSSMIB @FHLSPGR @LivUniEngageHLS @LivUniISMIB

[Colette Kelly @ColetteKellyyy]

@LippyLiptrott @FHLSPGR @LivUniEngageHLS @LivUniISMIB @LippyLiptrott I think creating models for each section of the GI system will help to further understanding, with a goal of being able to combine organ systems models in future. Once our lab reopens, I will be performing these 5-FU studies on murine colonoid cultures to compare.

[Colette Kelly @ColetteKellyyy]

@DaveFernig @FHLSPGR @LivUniEngageHLS @LivUniISMIB Thank you @DaveFernig! I have not tested potential protective agents on enteroids, I have seen papers of in vivo work using protective agents against 5-FU, I would definitely be interested to try it in vitro! 🙂

[Colette Kelly @ColetteKellyyy]

@LippyLiptrott @FHLSPGR @LivUniEngageHLS @LivUniISMIB @LippyLiptrott membrane and see if there are differences in the effects of toxicity. Comparison of the murine enteroids to e.g. human enteroid data has so far shown that murine enteroids are more sensitive to 5-FU doses.

[Colette Kelly @ColetteKellyyy]

@LippyLiptrott @FHLSPGR @LivUniEngageHLS @LivUniISMIB @LippyLiptrott Currently we are adding 5-FU to the enteroid media, meaning drugs are being exposed to the basolateral membrane of the epithelial cells. Colleagues have been working on microinjection techniques so we may be able to apply drugs to the lumen/apical (answer cont.)

[Colette Kelly @ColetteKellyyy]

@LippyLiptrott @FHLSPGR @LivUniEngageHLS @LivUniISMIB @LippyLiptrott however literature and other studies have found that organoids derieved from different sections of the gut do express proteins and transporters that are relative to the section of gut that the organoids were derived from

[Colette Kelly @ColetteKellyyy]

@LippyLiptrott @FHLSPGR @LivUniEngageHLS @LivUniISMIB Hi @LippyLiptrott, I feel that the enteroids do reflect the in vivo environment well - we can see crypt and villus regions within the enteroids to reflect the same structures seen in vivo. I haven't personally investigated transporter expression in enteroids (answer cont.)