Colonel Clearout

[Colonel Clearout @Colonelclearout]

@Towlie1981 Life comes at you fast!

Good thing our boys in blue are so committed to fighting crime rather than trolling cancer biotechs on X.

State of this man.

[J.K. Rowling @jk_rowling]

I don't want to shame any particular woman here, but publicly announcing that the #RussellBrand conviction must be wrong because you went home with him and he didn't rape you makes about as much sense as saying 'well, I left 25 Cromwell Street alive, so Fred West's innocent.'

[Colonel Clearout @Colonelclearout]

@roger_mabutt @gawbyliciious

[Colonel Clearout @Colonelclearout]

@roger_mabutt @gawbyliciious

[Colonel Clearout @Colonelclearout]

What utter bollocks. Welcome to Russia……

[Howard Cox @HowardCCox]

Kicking down the doors of law‑abiding motorists to check their mileage is an outrageous abuse of power. This pay‑per‑mile scheme turns every driver into a suspect and hands police Big Brother powers they neither want nor have time for. It’s yet another heavy‑handed attack on motorists from a government obsessed with control and grabbing even more cash from the highest taxed drivers in the world, instead of fairness

[Lee @LeePheonix360]

This is a John Cleese appreciation post

The man is a national treasure and a comedy legend and isn’t woke

@JohnCleese

[Colonel Clearout @Colonelclearout]

@Riccardino999 #Avct

[Jen k 🇬🇧🏴󠁧󠁢󠁥󠁮󠁧󠁿 @Jenny_1884]

Labour admits more than 200,000 people on benefits are better off than the average person working full-time in Britain.

Who else agrees that absolutely nobody should be better off on benefits than a working person?

It’s morally wrong.

[J.K. Rowling @jk_rowling]

Well, joke’s on you, because neither of us want Jolene to take our man.

[Colonel Clearout @Colonelclearout]

@RedDyke69 @RupertLowe10 Wow. You got into the gene pool whilst the lifeguard wasn’t watching. Mr Lowe is salvation. Those with brains can see that. In your case……….

[Canada Hates Trump @AntiTrumpCanada]

Hey in all fairness, if I was an 80-year-old fat fuck, riddled with dementia, while wearing a leg brace, a piss bag, shoe lifts & a full diaper, I probably wouldn’t be able to walk a straight line either. However, I could easily be an astronaut.

[BladeoftheSun @BladeoftheS]

Jared Golden was the one and only Democrat who voted to continue Donald Trump's war on Iran.

The vote was won by Trump by 214-213.

Won by just one vote, Jared's.

What a scumbag.

[Jen k 🇬🇧🏴󠁧󠁢󠁥󠁮󠁧󠁿 @Jenny_1884]

I accepted not receiving my State Pension until I’m 67yrs instead of 60yrs because we were told the country couldn’t afford it, but it grates on me now when they have been able to find the money for unknown people that have rocked up on our shores who have never contributed a single penny.

This is wrong & totally unfair.

[Colonel Clearout @Colonelclearout]

@lady_valor_07 Fixed it for you - wasn’t hard lol 😂

[Colonel Clearout @Colonelclearout]

@SeanDentBsc @tcanham459 Why don’t you shut the fuck up Mr I have a degree. You don’t even live here…….

[Colonel Clearout @Colonelclearout]

Mark Mitchell tearing RAH a new one is why I’m on twitter today!

#AVCT

[MM @emily1katie]

I think you assume the market is far brighter than it is, Robert. A big and regular mistake you make.

#AVCT’s invention (ie removing the need for an antibody, thus removing the need for an antigen target, thus removing an entire stage of the ADC process, is nothing short of groundbreaking).

Look at the amount of literature around antigen targets (just HER2 is a thesis in itself I find).

Targeting FAP and removing the need for an antigen turns the entire industry on its head.

It took me a very long time to understand it, despite having followed all the soundboard and the watched the spotlights. It’s not simple (I don’t care what anyone says).

If a change can disrupt many (multi billion) business models, it’s only right diligence should take time. Why shouldn’t it? It’s critical to them.

I know what I hold too. I know the management team. I understand the technology as best as I can. I understand the various personalities involved. But I also know the market (including the analysts and the institutions) are nowhere near as tuned in as you think they are. They will follow pharma into the trade. 100%.

That why I’m looking at the structure behind Avacta as much as the process in clinic. I’m expecting more broker changes and more NOMAD changes.

On 8/12/2025 Peel Hunt was listed as NOMAD on the RNS footer ���Preliminary Data in Faridoxorubicin Phase 1b Trial’.

On 17/12/2025 AVCT’s NOMAD was removed from the RNS footer.

Ironically, the change everyone craves (to ensure the technology is better represented) is well underway imho.

The company and board is a different beast.

As for whether the CEO could have discussed deals in the Q&A.

She’s MORE than bright enough to understand the bounds within which she can operate.

I believe Avacta is on the very cusp of the validation the market craves.

The technology works. AVA6103 is free at this price and AVA6000 in SGC alone is ascribed a chance of success around what did you put it at? 15%?

For a drug which is obliterating the PFS in an indication without a standard of care.

Those on the sidelines can sell it, buy it, short it. I don’t care.

I know what I hold.

As does a massive percentage of Avacta’s TVR.

The share price should be tapping on the door of 100p right now.

I’ve added today. Silence when Richard Hughes is sat next to Chris Coughlin is very different to silence without him sat on the Board.

I am surprised the market hasn’t grasped this.

[Colonel Clearout @Colonelclearout]

@Mucca85 @AriDrennen PERFECT ! unarguable

[Colonel Clearout @Colonelclearout]

@SeanDentBsc @onyx_gems @111BEN_111 @RAH00084 That’s utterly hilarious.

I would bet a limb @RAH00084 is immeasurably smarter than you, and unlike you he doesn’t need to add his 2nd rate degree to his handle.

As an old mate of mine often said “I ain’t got a degree but I’ve employed dozens who have !”

Pipe down! #avct

[Colonel Clearout @Colonelclearout]

@IndiaWilloughby @SolidusSna19226 India “knows” she’s a woman.

All the rest of us know he’s a bloke who is seriously #MENTALLYILL

It could stop there if he would keep his delusions to himself ….

BUT HE DOESN’T DOES HE ?

[Colonel Clearout @Colonelclearout]

@powndland Followed and I think you’ve got it pretty much spot on…….