Crohn's Zone

Crohn's suffer since 12/2011, Fecal transplant recipient (Thanks Mayo Clinic!), providing the latest news and research in Crohn's (Remission since June 2012)

[Crohn's Zone @CrohnsZoneBlog]

Recent colonoscopy from this past week (still in remission for Crohn's)...comments welcome

[Mayo Clinic Gastroenterology & Hepatology @MayoClinicGIHep]

Rochester’s IBD community is stronger when we come together! 💪Events like Rochester IBD Day create space for patients, families, supporters, and healthcare professionals to connect, share experiences, and build community around Crohn’s disease and ulcerative colitis. @MayoClinic, our IBD team is committed to advancing compassionate, multidisciplinary care for people living with inflammatory bowel disease—right here in Rochester and beyond. Check out @CrohnsColitisFn to learn of events in your area! @VictorChedidMD @LauraRaffalsMD
#IBD #CrohnsDisease #UlcerativeColitis #MayoClinicGIHep

[UChicago Medicine @UChicagoMed]

IBD can add challenges and complications to a pregnancy. An unique, specialized clinic at UChicago Medicine has gastroenterologists and maternal-fetal medicine doctors who work together to help pregnant women with IBD. https://t.co/JcSY2KxogB

[Edward Loftus @EdwardLoftus2]

@KakodkarSamir Let’s wait for the H2H results!!!

[Eric Topol @EricTopol]

A once a night pill for severe obstructive sleep apnea effective in a Phase 3 randomized trial
https://t.co/zq2Ew65WHK
https://t.co/ovQEh7taeN

[Mayo Clinic Gastroenterology & Hepatology @MayoClinicGIHep]

Gut health—and its impact on overall well-being—continues to be a major focus in medicine. This month, the #MayoClinic Guide to Gut Health is here. @Khanna_S shares clear, evidence-based insights on today’s most talked-about topics, from the gut microbiome to emerging therapies like virtual reality. Get your copy today: https://t.co/1mfq9gcuga

#GutHealth #Microbiome #DigestiveHealth #Wellness #EvidenceBased

[ASCRS_1 @ASCRS_1]

Gut Check Live starting shortly in the Innovation Center! Come stop by and bring your questions. #ASCRS26
@PubMEG @DrE_UCSD

[ASCRS_1 @ASCRS_1]

Gut Check is ready to go! #ColorectalFamilyFeud #ASCRS26
@Averywalker21 @EKing719

[Gastroenterology @AGA_Gastro]

🍟 Ultra-processed and unhealthy diet exposure, combined with abnormal gut host and microbial signals, persists despite effective treatments in #CrohnsDisease. Addressing these gaps could improve patient health.
🔗 https://t.co/jw7KeT5ro3

[Anita Afzali MD, MPH, MHCM, FACG, AGAF @IBD_Afzali]

🚨 Pub Alert @IBDJournals
5-yr outcomes from Phase 2 GALAXI 1 trial evaluating guselkumab in #CrohnsDisease
🔑 findings:
✅ Durable clinical efficacy thru 5 yrs
🔬 Sustained endoscopic outcomes
🛡️ Consistent long-term safety profile
📈 Growing evidence supporting IL-23 targeted therapy in #IBD

https://t.co/9HfQCVMpfK

🙌 to all patients, investigators & collaborators involved in this important work

[Mario Tomic @mariotomich]

Walking 7,000+ steps/day was associated with a 31% lower risk of depression.

Each additional 1,000 steps/day was linked with another 9% lower risk.

Walk daily. Your body and mind both depend on it.

[Edward Loftus @EdwardLoftus2]

FUZION trial of guselkumab for perianal Crohn’s disease—MRIs obtained at baseline, midpoint and end—approx 1/3 bio-naive—both doses equally effective at week 24. Great to have another well studied option for this troubling complication #DDW2026 @DDWMeeting

[Charlie Lees @charlie_lees]

Dose escalation of guselkumab in Crohn's disease - data from LTE of Galaxi 1/2

Endoscopic improve after 100mg q8w to 200mg q4w ... BUT also after sham adjustment from 200mg q4w to 200mg q4w

What does this mean?
What patients need dose escalation?

A trial of dose escalation in patients on 100mg q8w with objective evidence of active inflammation makes sense - there are no down sides .... right?

EXCEPT:

For many of us outside of N America, moving from q8w to q4w dosing = doubling of drug costs

Perhaps we are left with more questions:

Can we get away with 200mg q8w?
This provides 2x the drug for the same cost

Rememer the primary readout of GALAXI 1/2 showed no significant different between 100mg q8w and 200mg q4w.

Perhaps ... partial responders (? on either dose) might derive more benefit from a switch to an alternative MoA OR addition of a second AT

A 12w blast of 45mg UPA to capture remission?
The VICTRIVA study is partially testing this strategy in CD using vedo +/- 12w of UPA

All pure speculation ... interested in your thoughts.

[Tauseef Ali MD, FACG AGAF FACP @ibdtweets]

We reduced deaths from IBD, but not deaths with IBD

🌸 Absolute mortality ↓ improving in both CD and UC
🌸 Relative mortality
UC → neutral
CD → increased (HR ~1.34)
🌸Drivers of excess mortality
Infection (sepsis)
Malignancy (CRC, lymphoma)
Systemic disease (renal, pulmonary)
#ddw2026

[Mikli @CryptoMikli]

Sleep doctor reveals how drinking coffee and taking a quick nap can reset you for up to 4 hours

“You take a cup of drip black coffee, just throw in a couple of ice cubes, right, merely to cool it down, drink it as fast as you can, then immediately take a 25 minute nap. The adenosine that’s built up in your brain will burn through while you’re napping, and caffeine, since it’s so close in molecular structure, can fit into that receptor site. It blocks any new adenosine. You’re good for four hours, guaranteed”

“I use it with every CEO that I work with. Let’s say you only got three hours of sleep the other night and you’ve got a big presentation to do or an award ceremony or something like that, you can do a nappa latte for about 25 minutes or so, and you will feel much better”

[Healio Gastroenterology @HealioGastro]

🤖 The era of AI-assisted #colonoscopy may have boosted adenoma detection and cut interval #ColorectalCancer by 4️⃣7️⃣%.

🗨️ “A signal that size in real-world data was notable,” Dr. Muhammad Ali Butt @Alibutt1995 of @UMN_GIHep said. #DDW2026 https://t.co/c4v94Qfmtc

[BowTiedPhys @BowTiedPhys]

150 minutes/week of walking was associated with lower risk of 13 different cancers by up to 42%.

[Crohn's Zone @CrohnsZoneBlog]

@EricTopol @TheLancet Eric I am curious what the results of a fecal transplant + psychedelics + Ozempic would look like for reducing alcohol consumption. All individually have shown reduction of alcohol consumption.

[Eric Topol @EricTopol]

First randomized trial to show Ozempic reduces alcohol consumption in people seeking treatment for alcohol use disorder. Placebo-controlled, double-blind. Participants with BMI >30 kg/m2.
https://t.co/M9Pk2gzKHD @TheLancet

[Science News @SciencNews]

Higher physical activity is significantly associated with lower biological age

[Eric Topol @EricTopol]

An AI that detects occult pancreatic cancer better than radiologists (73 vs 39%) via CT with external validation
https://t.co/NIiIFjlyxp