Prof Doug Kell CBE #FBPE #FBPA🔶🇪🇺

I tweet in a personal capacity. ENTJ. CBE. Against brexit/Govt lies. #FBPE Nothing I say is medical advice

[Prof Doug Kell CBE #FBPE #FBPA🔶🇪🇺 @dbkell]

We have written a free book (monograph) on why people believe crazy things, including #Brexit . You can download it at https://t.co/42epKzVgpl #openaccess #FBPE - please RT #beliefbook @beliefbook

[Prof Doug Kell CBE #FBPE #FBPA🔶🇪🇺 @dbkell]

I'm giving an online webinar/talk on microclots in #LongCOVID and #MECFS on Wednesday this week June 17 at 2pm UK time. Registration required but free https://t.co/yphBGHd2OM #TeamClots

[Harry Spoelstra @HarrySpoelstra]

Immunothrombosis in hospitalized COVID-19 patients identified by multiomics profiling and linked to postacute complications

🚨INTERESTING New Latvian/Swedish multi-omics study shows immunothrombosis never fully switched off in longC0VID patients: 3 months after COVID hospitalization, your blood is still biologically “clot-ready.”

➡️What makes this study so important:
1. It reinforces that immunothrombosis (the interplay of complement, NETs, and platelets) is a central driver in severe acute COVID-19 and can persist in longC0VID,
2. It confirms persistent endothelial Dysfunction/Endotheliopathy in longC0VID patients, consistent with earlier studies on vascular damage and microclots,
3. It aligns with prior evidence of mitochondrial dysfunction during the acute phase, followed by partial repair mechanisms,
4. The persistent complement activation they observed fits with other recent multi-omics studies showing ongoing complement dysregulation in longC0VID.

➡️Study:
1. Prospective longitudinal multi-omics study of 81 hospitalized COVID-19 patients tracked whole-blood transcriptomics, urine metabolomics (46 analytes), and 13 kidney-injury biomarkers at acute admission, ~1 month, and ~3 months post-hospitalization,

2. Patients stratified by EHR into recovered (n=35) versus long COVID (n=46) groups based on a PASC diagnoses within 12 months,

3. None of the 81 hospitalized patients were vaccinated,

4. Acute phase dominated by interconnected immunothrombosis: strong upregulation of complement (C1QA/B/C), NETosis (PADI4, MPO), and platelet-activation genes (ITGA2B, ITGB3), plus mitochondrial dysfunction (HIF1A/EPAS1 up, OXPHOS down, Warburg-like glycolysis) and elevated renal injury markers (KIM-1 etc.),

5. Most immune, mitochondrial, and metabolomic changes largely normalized by 1–3 months, with rebound in mitophagy/heme genes (PINK1, OPA1, FECH) indicating repair,

6. At 3 months, longC0VID patients showed a distinct transcriptional signature of persistent endothelial activation (↑VWF, PROS1, ITGA2B/ITGB3), complement dysregulation (CFH), and low-grade vascular inflammation/platelet reactivity (CXCL5, ALOX12) that was absent in recovered individuals,

7. No significant late differences in urine metabolomics or kidney biomarkers between groups.

➡️They conclude with their Highlight-points:
• Severe COVID-19 induces immunothrombosis-associated molecular programs,
• Acute COVID-19 is associated with mitochondrial metabolic dysregulation,
• Urine profiling indicates gradual renal recovery after hospitalization,
• LongC0VID patients retain endothelial-associated activation signatures.

‼️So, even after apparent clinical recovery, immunothrombosis leaves a persistent molecular scar of endothelial activation and prothrombotic signalling in longC0VID patients at three months, revealing that the acute vascular battlefield never fully quiets in those who remain symptomatic.

→Three months post Covid-19, longC0VID patient’s blood is still biologically primed to clot!
#AvoidSars2 #AvoidReinfections
https://t.co/PQWLlgx8kp

[Prof Doug Kell CBE #FBPE #FBPA🔶🇪🇺 @dbkell]

You'd have to say Morocco's footie team look terrific... #wc2026

[Long Covid Advocacy 💙 @LongCovidAdvoc]

Template:
I'm joining the call for up-to-date scientific representation & meaningful patient engagement in Long Covid and ME. I'm proud to support the Open Letter to RCPsych, backed by 58 orgs & 1200 signatories. #HearOurVoices #RCPsychIC
📩 https://t.co/cWgFuTQJaN
(add image 👇️)

[Long Covid Advocacy 💙 @LongCovidAdvoc]

🗞️ Stop Press: MON 15th - We are coordinating an outreach campaign to the Royal College of Psychiatrists Congress to ensure the community's concerns about the framing of Long Covid are heard.

This is a powerful opportunity for them to #HearOurVoices

Template to C+P below 👇️

[Prof Doug Kell CBE #FBPE #FBPA🔶🇪🇺 @dbkell]

And IMHO a lot of people will lose a lot of money when they realise how much of it is vapourware...

[ALASTAIR CAMPBELL @campbellclaret]

Media covering Musk trillion without any real regard to broader issues of inequality, tech bro abuses of power, his extreme politics. Glad to have been in a primary school this morning where the views on Musk were a lot wiser and less flattering.

[Prof Doug Kell CBE #FBPE #FBPA🔶🇪🇺 @dbkell]

https://t.co/hpEysbedxW

[🔬 Guty Schnauzer | Long COVID & Ciencia @guty2370]

🔗 Paper

COVID-19 as a Modifier of Genetically Determined Coagulation Phenotype: Implications for Precision Risk Stratification After Infection
FYI/@resiapretorius
https://t.co/qjOv8Gwuow

[Paul Schleifer @PaulSchleifer]

Which public health crisis gets the least media coverage relative to its actual scale?

Air pollution: about 30000 UK deaths a year.

Long COVID: around 2 million people affected in England and Scotland.

Antimicrobial resistance: estimated to contribute to 35000+ UK deaths a year, likely to grow.

Mental health: when services fail, the consequences don't stay in clinics. They show up in families, homelessness, A&E, schools, policing, safeguarding failures... and sometimes riotous national crisis.

[Prof Doug Kell CBE #FBPE #FBPA🔶🇪🇺 @dbkell]

Not just water. UK 7th most expensive country for electricity too... https://t.co/sJxWeQPzfp #RipOffBritain

[Prof Doug Kell CBE #FBPE #FBPA🔶🇪🇺 @dbkell]

@ShoreBird5962 @DarainChains @TMaritanoAquino Kell, D. B., Heyden, E. L. and Pretorius, E. (2020) The biology of lactoferrin, an iron-binding protein that can help defend against viruses and bacteria Frontiers Immunol. 11, 1221. https://t.co/Rk2wGNgPc1

[dave lawrence 🐟🐟🐠 @dave43law]

This needs posting everywhere

[Jenny Jones @GreenJennyJones]

Water is too precious and sewage too dangerous to be in private hands.

[Feargal Sharkey @Feargal_Sharkey]

The call for public ownership of the water industry is growing louder everyday.

Why are govt refusing a referendum, why are govt refusing to allow the public to decide?

https://t.co/RIWSwgPl7u

[Prof Doug Kell CBE #FBPE #FBPA🔶🇪🇺 @dbkell]

Thames Water wants to set its own rules. The Board of Ofwat is split over whether to let them. Tip the scales in favour of people and planet: email the Board now, and urge them to reject Thames Water's creditors @We_OwnIt https://t.co/8Grc00CEPT

[Prof Doug Kell CBE #FBPE #FBPA🔶🇪🇺 @dbkell]

https://t.co/i9O1P6saFe

[Prof Doug Kell CBE #FBPE #FBPA🔶🇪🇺 @dbkell]

Reality Defies Trump-Friendly Predictions https://t.co/BnUXtp4pw2

[Prof Doug Kell CBE #FBPE #FBPA🔶🇪🇺 @dbkell]

@TMaritanoAquino @ShoreBird5962 @DarainChains Same answer - ferritin has no business in plasma.

[Prof Doug Kell CBE #FBPE #FBPA🔶🇪🇺 @dbkell]

@ShoreBird5962 @TMaritanoAquino @DarainChains 100%

[ALASTAIR CAMPBELL @campbellclaret]

I think he means you and yours @RupertLowe10 @Nigel_Farage - maybe take heed this time.