Dan Sarni

Postdoc in the Jackson lab @mrc_hgu. Genome instability, DNA methylation and replication

[Dan Sarni @DanSarni]

📢 For a quick overview of our work please check out this research briefing as well https://t.co/bIhUWbGhT9

[Dan Sarni @DanSarni]

📢What if DNA methylation changes aren’t just ticking of our biological clock but rather the rust breaking the gears? 🚨Very excited to share our work - how DNA methylation contributes to stem cell dysfunction and aging, published in Nature Genetics https://t.co/yQUNnwkO9l

[Dan Sarni @DanSarni]

This work is truly the result of a team effort and there are many people to thank at @mrc_hgu and beyond. But it could not have been possible without Grainne Neary, Paula Carroll, Martin Reijns, @sproul_lab and Andrew Jackson

[Duncan Sproul @sproul_lab]

We've been awarded a UKRI MRC grant to examine the causes and consequences of #heterochromatin hypomethylation in cancer 🥳. #postdoc opportunity coming in the near future. #epigenetics. Please share with anyone who might be interested.

[Duncan Sproul @sproul_lab]

🚨New Review🚨 We've recently seen huge advances in our understanding of de novo DNA methyltransferase function. @WillowRolls and @mdrwilson and I have written a mini-review on what human disease mutations told us:
https://t.co/GDIdhdEcud
#Epigenetics #Epigenomics 🧵 1/2

[Noa Lamm @LammNoa]

I have recently opened my lab at #CMRI_AUS and am looking for an enthusiastic postdoc to join my team. (Details below.) Please help me with RTs. Thank you!

[Andrés Aguilera @AguileRloop]

Our new paper on new factors preventing and resolving harmful R-loops is out, thanks to all authors and to our great collaborator
@XiaoyuXue
@unisevilla @CSIC @CancerCSIC @cabimer
https://t.co/Cn8VaDHvr6

[SheqLab @ShechnerLab]

It's my great pleasure to present the first preprint from SheqLab: a tech-dev project that we think will transform RNA biology.

If you want to discover the cellular factors an RNA interacts with—practically any RNA, in nearly any context—I think you'll want to try O-MAP. (1/19)

[Atilgan Yilmaz @Atilgan__Yilmaz]

Looking for an enthusiastic #postdoc, who is interested in understanding human skeletal muscle development and diseases using in vitro stem cell-based models. Please feel free to share with potentially interested candidates! #postdocposition

https://t.co/hhVGw6xgwL

[Dan Sarni @DanSarni]

And maybe it was all known already. To quote Shakespeare’s friar Laurence advising Romeo:” Wisely and slow, they stumble that run fast”. Perhaps it is true for polymerases as well…

[Dan Sarni @DanSarni]

I'm excited to share our latest work on the effect of excess Topoisomerase 1 (TOP1) on R-loops and DNA replication dynamics, leading to aberrant fork acceleration and DNA damage in pre-senescent oncogene expressing cells, available on @CellReports.
https://t.co/z3BKVmBslA

[Dan Sarni @DanSarni]

This work was done in collaboration with @AguileRloop and the wonderful Sonia Barroso, and could not have been possible without the incredible Michal Irony-Tur Sinai, @AlonShtrikman and @OrenYifat. Thanks also to @MartinReijns. It has been a long journey, thanks Batsheva Kerem.