Dario Amodei

Anthropic CEO.

[Dario Amodei @DarioAmodei]

Today we announced the Claude-led discovery of a molecular machine that we suspect could represent a new gene editing mechanism. Its precise function, biotechnological utility (if any), or level of significance is not yet clear, but at minimum it is work I would have been proud to do as a PhD student. The work was done mostly, though not entirely, by Claude: our life sciences team suggested a broad area of research, Claude read through the literature and a bunch of genome data and discovered something interesting, then Claude proposed experiments to verify the discovery and our team carried them out.

It’s easy to dismiss this as a one-off or curiosity, but we’ve repeatedly seen a pattern where AI performance in new intellectual domains goes from weak to superhuman in a matter of a few years. In 2023 models struggled to do math at the level of an average high-school student. In 2024 they started to do well on math competitions for the best high-schoolers in the country, in 2025 they started to solve minor open problems, in early 2026 more significant open problems, and in late 2026 they are beginning to solve the top few open problems in all of mathematics. We believe AI for biology is on a similar exponential trend.

The main difference between biology and mathematics, of course, is that math can be done purely theoretically, while biology requires experimentation. Some have used this to draw the conclusion that AI’s utility in biology will be limited. We think this is wrong. As we’ve demonstrated today, humans can collaborate with AI to perform the experiments, validate key results in a few weeks and, if necessary, work with the AI to iterate on what they find. Eventually it may even be possible for Claude itself to safely perform the experiments by autonomously controlling lab equipment, with appropriate safeguards in place, but we aren’t doing that today (our lab is also a BSL1/BSL2 facility that doesn't handle materials dangerous to humans).

More broadly, biomedical advancement has many stages — from fundamental biology discoveries, to translational research, to drug discovery, clinical trials, and finally the actual delivery of medicines and health care to patients. We are also interested in these later stages, but even simply accelerating the first stage of fundamental biological discoveries has the potential to speed up and broaden the entire pipeline. Improving our understanding of biology and sharpening biologists’ tools can drive forward all of the later stages, for example by identifying new drug targets, finding new therapeutic modalities, allowing for more precise measurement, and speeding up the experimental loop which itself further accelerates our understanding of biology. This will not in itself speed up clinical trial times, but if it succeeds it could greatly increase the number of promising candidates that go into the pipeline — an increase in throughput even though latency remains.

In Machines of Loving Grace, I wrote about AI’s potential to “cure most diseases in 5-10 years” — a goal that sounds impossible, but one I believe is just barely possible if AI is applied to every stage of the pipeline. The first step is showing that AI can first help with, and then drive, biological discoveries.

Claude’s discovery is the latest in a line of related prior work that goes back decades, beginning with systems like CRISPR, and continuing with discoveries like the bridge recombinase and VIPR in the past few years. Recently, there has been heightened interest in systems based on reverse transcriptase (RT) enzymes, the enzyme underlying the system Claude identified. And most recently, a Stanford team working independently described a novel RT system with an associated non-coding array that is in some ways similar to the one Claude found, though they are distinct systems that evolved independently from each other. I believe that we’re at the very beginning of finding such systems and developing them into powerful tools for biotechnology.

I’m proud of the resources Anthropic has invested in accelerating the public benefits of AI through the life sciences, and we’re aiming both to grow our life sciences team and to work with other scientists to extend this approach to a broad range of problems. If you have a proposal for a research collaboration or are interested in joining our life sciences team, please reach out.

[Anthropic @AnthropicAI]

Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR.

We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use.

Read more: https://t.co/RuEosScSMb

[Dario Amodei @DarioAmodei]

We Must Pace the Frontier: I’ve written a new essay on why the AI industry should slow down, with a three-part plan for doing so.

Anthropic is unilaterally committing to the first of these steps. We’ll provide third-party evaluators with permanent, employee-level access to our systems, so that they can verify adherence to our safety measures, report on incidents, and assess models’ alignment during training.

You can read the full post here: https://t.co/OGyPb7yaYt

[Dario Amodei @DarioAmodei]

2/2 Second, on the messaging around AI.  I do not agree that my messaging has been disproportionately negative.  In fact it has been about equally balanced between risks and benefits: I’ve written one major essay about each, and even in interviews where I discuss the risks, I make sure to frequently mention the incredible benefits as well as proposing possible solutions to the risks (short clips from my interviews that end up on social media tend to be disproportionately negative, as that gets clicks).  In fact, I wrote Machines of Loving Grace because I didn’t feel the AI industry was painting an inspiring enough picture of how the technology could radically transform the world for the better.  The bulk of the essay is devoted to refuting skepticism of AI’s potential in health and biology, and showing why I think it will actually be possible to cure most human disease in ~5-10 years, as crazy as it may sound to ordinary people and frankly to biologists as well (I used to be one!).  And, if you read my most recent essay (Policy on the AI Exponential), I discuss concrete proposals for how to streamline the FDA process to make sure the deluge of AI-accelerated drugs isn’t slowed down by the regulatory process.  I feel the urgency here: I lost my father to Hepatitis C only a few years before the development of direct-acting antivirals (sofosbuvir), which cure 95% of patients and probably would have cured him.

I do agree that the public has a negative view of AI (and that this is a big problem), but I don’t think it is primarily caused by me or any other AI leader warning about AI’s risks.  I think it is fundamentally a crisis of trust.  I think that ordinary people don’t trust companies, governments, or the tech industry and always suspect that we are cooking up some new way to screw them over.  The causes of this go back decades and AI is just the latest iteration of it.  I don’t think that a glitzy marketing campaign with a positive spin (which some have advocated that Anthropic do) is the way to win back that trust — at this point, saying that AI will cure cancer is more a cliche than it is inspiring, and most people think it is deceptive.  The thing that will work is *actually curing cancer*.  I think by far the most accurate criticism of AI companies including Anthropic is that we haven’t yet delivered on our big promises to benefit the world.  That is totally on us, and I think it’s the criticism you should be making, instead of all this stuff about messaging and marketing.

We are however doing our best to fix this: Anthropic is ramping up its efforts very quickly in biology and medicine, and we hope to have incredible results in the coming years and some early glimmers in the coming months.  When we’ve actually accomplished something real, the whole world will hear about it, as loudly as possible, you have my word on that.  But until then I don’t want to make empty promises, and in the meantime I feel compelled to speak honestly about the very real risks of AI and how to address them.  Honesty is the right thing on the merits, and in terms of public credibility and trust it is no worse than, and may in fact be better than, an approach that ignores or distracts from risks which people instinctively understand are real.

[Dario Amodei @DarioAmodei]

1/2 Thanks Gavin for an especially thoughtful exchange. I don't usually spend much time on social media but I wanted to engage here because it really brings out the heart of an important conversation.

First, on regulation, I think that “either concentrate it in the hands of a chosen few companies and politicians via regulation or distribute it widely” is a false choice.  I know that there’s a sort of Silicon Valley shorthand where regulation = regulatory capture = concentration of power, but I’ve always found this to be an overly simplified picture of the world.  Many people outside this bubble think of regulation as something that constrains corporate power and benefits ordinary people.  I don’t necessarily agree with that perspective either, rather I think it’s complicated and really depends on what the “regulation” consists of.  But in particular I think that those in the “regulation = regulatory capture = concentration of power” frame often underrate the decentralizing power of objective and fair institutional processes.  A crude analogy is that the formal court system can sometimes feel stuffy and elitist, but it does a much better job of defending the rights of vulnerable individuals than the alternative, mob justice.  At their best, institutions can vest power in ideas rather than people, and thereby decentralize that power.

This is why Anthropic has always made its policy proposals very carefully.  We try very hard to make proposals that disadvantage (slow down) frontier AI companies while *advantaging* smaller competitors.  California’s SB53 (which we supported), and even the much-maligned SB 1047 (which we were ambivalent on), completely exempt any company below a certain amount of revenue or model training costs from being covered at all (it was $500M for SB 53, lower for 1047 but we objected to that).  More recently the testing process we’ve advocated for at CAISI and the White House involves more rigorous tests for frontier models than off-frontier models — something that differentially advantages challengers.  Similarly, the “Pacing the Frontier” letter envisions (or at least Anthropic’s preferred implementation of it envisions) modulating the pace of the very best models while not constraining those who are catching up.  This hurts the business interests of the frontier labs and helps challengers, including open-weights!

Overall my view is that AI is *structurally* a technology that tends to concentrate power, for reasons that have nothing to do with regulation (more to do with the extreme implications of the scaling laws).  Open-weights do help some with this but are nowhere near a sufficient solution because they simply shift the concentration somewhat to those with the most compute and chips (which are roughly the frontier labs plus maybe hardware providers).  By contrast I think the right “rules of the road” can simultaneously (a) address AI’s cyber/bio/alignment risks, (b) institutionally constrain the power of the frontier AI companies, and (c) leave room for open-weights models while also addressing the specific risks that they bring.

BTW I do not think that the events of the last few months have “failed to result in [my] preferred regulatory path”.  The approach that the Trump administration is reported to be taking — pre-deployment testing for frontier models, and also testing of open-weights models when they get closer to the frontier — is one that I am very supportive of, though of course I have to see the details to be sure.  I am also supportive of Demis Hassabis’ ideas around a FINRA-like entity.  This contrasts with six months ago when most of the industry was still pushing for preemption of all state regulation and no apparent federal approach either.

[Gavin Baker @GavinSBaker]

Sholto, thank you for setting the record straight. Larger issue is that multiple very serious people in Silicon Valley have heard some variation of this and believe it to be true. And the reason it is believable to so many is that it is consistent with Dario’s public messaging and what he outlined in the essay you shared: this technology *might* be dangerous for humans in multiple ways, could lead to extreme concentration of economic power (as outlined in the essay) and therefore needs to be regulated thoughtfully. I agree with the potential risks and I believe Dario makes all of these arguments in good faith.
���As discussed on the pod, if one agrees that AI *might* be dangerous, there are two ways to address this potential risk. Either concentrate it in the hands of a chosen few companies and politicians via regulation or distribute it widely. Essentially boils down to whether one believes AI is too dangerous to concentrate or too dangerous to distribute. There are reasonable arguments on both sides, but I profoundly agree with Zuckerberg’s statement that: “The notion that AI is so dangerous that the only safe path is an extreme concentration of power seems inherently problematic. Historically, hoping that an absolute power will benevolently provide for humanity if sufficiently enlightened has not led to safe or positive outcomes.” And as Dario says in the aforementioned essay, “some may object that we can simply keep AIs in check with a balance of power between many AI systems, as we do with humans.” I believe this is the best path forward: I want as many AIs as possible to maximize the odds that one shares my own particular values. And as Dario notes, no human has ever been able to take over the world.

At this point, I think safe to say that Dario has lost the argument. His messaging has failed to result in his preferred regulatory path. The fact that the only solution to the recent incident where an unreleased advanced OpenAI model hacked Hugging Face was an open-source model likely ended any chance of strict near-term regulation. Essentially every major company other than Anthropic has signed Jensen’s letter.

However, Dario’s messaging has been massively helpful to efforts to ban datacenters here in America. I suspect we will see anti-datacenter advocacy groups runnings ads using clips of Dario warning about how dangerous AI could be for humans. His good faith efforts in favor of regulation are now increasing the odds that AI will not be beneficial for Americans and humans everywhere. I believe that there is a reasonable chance AI might help us cure most forms of disease such that we have extended lifespans and can enjoy these long lives in an abundant Star Trek like future. That is the future that I want and I think Dario is decreasing the odds of that future at this point.

He is about to be the CEO of one of the most important public companies in the world and given that the pro-regulatory effort has failed (at least for now), I respectfully think he should make an effort to be a more positive advocate for his own industry. And if I am wrong and we do need to regulate this technology, he will be a more effective advocate for this in the future having been open-minded to the alternative.

And for the sake of clarity and as I outlined on the pod, I think Anthropic has deep competitive advantages and is an amazing company. Ironically, the main risk I saw to Anthropic a few months ago was nationalization as a result of Dario’s own rhetoric and behavior.

[Dario Amodei @DarioAmodei]

Many of these policy ideas have common-sense appeal across the political spectrum, and the sooner we act on them, the sooner everyone shares in AI's benefits.

[Dario Amodei @DarioAmodei]

In addition to transparency, I now believe frontier models should face mandatory third-party testing for cyber, bio, and autonomy risks—with the power to block or revoke deployment of models that pose catastrophic risk.

[Dario Amodei @DarioAmodei]

Alongside it, Anthropic is releasing a proposal for how governments can address the risks posed by frontier AI and a policy framework for job displacement, for which we intend to provide substantial financial backing. https://t.co/P0W2lIKbdY

[Dario Amodei @DarioAmodei]

Anthropic has long advocated for transparency requirements for frontier AI, because the risks weren't yet clear enough to regulate precisely. That is no longer sufficient.

[Dario Amodei @DarioAmodei]

Today I'm publishing a new essay, Policy on the AI Exponential. AI is progressing extremely fast—much faster than the policy process was built to handle. The essay lays out where I think the technology is now, and the action needed to close the gap: https://t.co/Lh6PWae178

[Dario Amodei @DarioAmodei]

Cyber is the first clear and present danger from frontier AI models, but it won’t be the last. If we are able to collectively rise to the challenge and confront this risk, it could serve as a blueprint for addressing the even more difficult challenges that lie ahead of us.

[Dario Amodei @DarioAmodei]

I’m proud that so many of the world’s leading companies have joined us for Project Glasswing to confront the cyber threat posed by increasingly capable AI systems head-on.

https://t.co/pn3HSVsThP

[Anthropic @AnthropicAI]

Introducing Project Glasswing: an urgent initiative to help secure the world’s most critical software.

It’s powered by our newest frontier model, Claude Mythos Preview, which can find software vulnerabilities better than all but the most skilled humans.
https://t.co/NQ7IfEtYk7

[Dario Amodei @DarioAmodei]

The dangers of getting this wrong are obvious, but if we get it right, there is a real opportunity to create a fundamentally more secure internet and world than we had before the advent of AI-powered cyber capabilities.

[Anthropic @AnthropicAI]

A statement from Anthropic CEO Dario Amodei: https://t.co/WnSFrwI9nI

[Anthropic @AnthropicAI]

A statement from Anthropic CEO, Dario Amodei, on our discussions with the Department of War.

https://t.co/rM77LJejuk

[Dario Amodei @DarioAmodei]

I've been working on this essay for a while, and it is mainly about AI and about the future. But given the horror we're seeing in Minnesota, its emphasis on the importance of preserving democratic values and rights at home is particularly relevant.

[Dario Amodei @DarioAmodei]

The Adolescence of Technology: an essay on the risks posed by powerful AI to national security, economies and democracy—and how we can defend against them: https://t.co/0phIiJjrmz

[Dario Amodei @DarioAmodei]

It's a companion to Machines of Loving Grace, an essay I wrote over a year ago, which focused on what powerful AI could achieve if we get it right: https://t.co/TDKfXIPw15