David Ford

Process chemist with interests in flow chemistry and data-rich experimentation

[Frances Arnold @francesarnold]

Today I decided that #directedevolution is finally ready to be run entirely by #machinelearning. No more painful experiments to get your long-dreamed-for #enzymes! Grad students and postdocs can just push a button.

[David Ford @DaveFordChem]

@awhspeed People put their balances on marble blocks to make the table vibrate less.

[David Ford @DaveFordChem]

@SafeChem79 I nominate Vilsmeier–Haack

[David Ford @DaveFordChem]

@MarekGrb I think you might be on to something! It was a nitrile reduction, so ammonia is a byproduct.

[David Ford @DaveFordChem]

Look what I found growing in the half-forgotten, three-week-old aqueous phase of my workup from a DIBAL-H reduction! Most definitely the biggest single crystal I’ve seen outside of a geology exhibit and it made my day. Any guesses what it is?

[David Ford @DaveFordChem]

@djavko Sulfuric acid quench, so presumably an aluminum sulfate of some kind... it was crystal clear before I pushed it to the back of the hood.

[David Ford @DaveFordChem]

Very excited to see this in print! This project is the product of really great teamwork between Amgen, FIS, and @SnapdragonChem

[Organic Process Research & Development @OPRD_ACS]

Amgen team describes a multi-stage continuous flow O-methylation to prepare AMG-397, an oncology candidate, in 75% yield on > 10 kg scale.
https://t.co/1Rz5nTKkLl

[David Ford @DaveFordChem]

Enjoyed working on this with the talented team @SnapdragonChem ! A great example of continuous reactors making some seriously challenging chemistry a lot more practical.

[Organic Process Research & Development @OPRD_ACS]

Snapdragon has developed an on-demand diazomethane generation system that delivers up to 0.44 mol/h from N-methyl-N-nitroso-p-toluenesulfonamide in ∼80% yield.
https://t.co/p8cR6jNnSp

[David Ford @DaveFordChem]

@DrLCsquare Strongly agree. I wish I had that opportunity when I was in grad school. Six months is a drop in the bucket of a 5-year PhD and if you come back inspired and with new perspective, you will easily make the time back up.

[David Ford @DaveFordChem]

@danithechemist F4 in Excel to toggle between “dollar sign” options: freeze cell, freeze column, freeze row!

[David Ford @DaveFordChem]

@ZachWickens That’s super cool!

[David Ford @DaveFordChem]

@Chemjobber

[Rebecca Ruck @Ruck_chem]

#EWOC2020 registration is now open! August 13-14 virtually. Speakers: @Vy_Dong_Group @JuliaKalow @DonnaBlackmond Nicola Webb @CarolynBertozzi. Organizers include @DMHuryn @MPWatsonLab @faul_margaret. @EWOC8 @ACSorganic #womeninchemistry https://t.co/ZjBRC356uy

[Dr. Donna Huryn @DMHuryn]

What happens a week from today? Registration for @EWOC8 opens-It'll be different, but still awesome. @CarolynBertozzi @Vy_Dong_Group @DonnaBlackmond @JuliaKalow speaking. Everyone welcome-we actually believe diversity is good for ochem. @MPWatsonLab @ACSorganic @Ruck_chem

[David Ford @DaveFordChem]

@jenheemstra Impurity co-elutes with major enantiomer

[David Ford @DaveFordChem]

@SongLinLab @SnapdragonChem Thank you for inviting me! I enjoyed the discussion very much.

[David Ford @DaveFordChem]

@sarah_reisman Real talk!

[David Ford @DaveFordChem]

@M_J_Ardolino Nice! We have been doing the same thing over here!

[SnapdragonChem @SnapdragonChem]

@SnapdragonChem Virtual #HappyHour! Connecting with each other during the MA #StayAtHome. Hope you and you family staying safe! During this difficult time take time and reach out to your family and friends. #FlattenTheCurve #WashYourHands #SocialDistanacing #COVID19 #FLOW ~ DP

[David Ford @DaveFordChem]

@kurtreynertson @Chemjobber If you don’t want to hand over control of your router: https://t.co/lRqmm3j0fc